Effect of Immunization with Cysteine Protease from Phase-Separated Parasite Proteins on the Erythrocytic Stage Development of the Chloroquine-Resistant, Plasmodium berghei in BALB/C Mice

Amlabu, Emmanuel; Nok, Andrew J.; Mairo, Inuwa H.

doi:10.4172/2155-9597.1000119

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Anti Malarials1

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2012

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“…Due to the acquired global resistance of malaria parasites to antimalarial drugs, there is need for new approaches to malaria treatments. Targeting of enzymes which play pivotal roles in the parasite's life cycle is being executed to overcome the resistance of the organism [12]. Treatment with cysteine protease inhibitors blocks hemoglobin hydrolysis and parasite development in vitro.…”

Section: Anti Malarialsmentioning

confidence: 99%

Antibiotic Resistance Creating New Epoch

Praveenya¹,

Singh²,

D³

et al. 2012

J Bacteriol Parasitol

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Antibiotics are an efficient means of treating bacterial infections. They help in the reduction of mortality and morbidity. Discovery of antibiotic has created a new epoch where infectious diseases have been put to an end. But the organisms have developed resistance during the course of evolution due to mutations. The major problem which is being faced is the treating of infectious diseases caused by microbes which have developed resistance. The antibiotic resistance is being carried by the organisms due to acquisition of resistance genes to next generations by horizontal gene transfer. The present review is focused on what are the various mechanisms adopted by the organisms against antibiotics and new techniques involved in treating the infectious diseases and methods to overcome the antibiotic resistance.

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Section: Anti Malarialsmentioning

confidence: 99%