Effect of imidacloprid on the behavior, antioxidant system, multixenobiotic resistance, and histopathology of Asian freshwater clams (Corbicula fluminea)

Yuan, Songmei; Yan, Saihong; Hong, Xiangsheng; Zha, Jinmiao; Qin, Jian-Hua

doi:10.1016/j.aquatox.2019.105333

Cited by 69 publications

(27 citation statements)

References 45 publications

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“…SOD and CAT are considered the primary antioxidant enzymes that contribute to the balance of free radicals in organisms and their activation is thus needed 35 . The activity of CAT was signi cantly enhanced in the sh digestive glands and gills following 30 days of Imid exposure 17 . In agreement, in this research, the SOD, CAT and GPX activities in the liver tissues were signi cantly increased in shes receiving Imid treatments, which may be due to the production of ROS 35 .…”

Section: Discussionmentioning

confidence: 96%

“…Animal management procedures were undertaken in accordance with the requirements of the Institutional Animal Care and Use Committee (IACUC), Menou a University, Egypt. The protocol of this study has been approved by the ethics review board of the IACUC of Faculty of Science (ID: MUFS-F-EC- [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. The experiments in this study were in compliance with the ARRIVE guidelines. )…”

Section: Animalsmentioning

confidence: 99%

“…Australoheros facetus, exposed acutely to environmentally relevant concentrations of Imid (1 to 1000 µg/L), showed oxidative damage affecting the genetic integrity of the sh 16 . Changes of the cellular detoxi cation and oxidative status of Corbicula uminea were also reported 17 . Fish leukogram was reported to be affected due to sub-lethal concentrations of Imid (140 and 280 mg/L of imidacloprid for 96 h) 4 .…”

Section: Introductionmentioning

confidence: 97%

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Imidacloprid Induces Oxidative Stress and Genotoxicity in Nile Tilapia: The Role of Ascorbic Acid Combined Exposure

El-Garawani

Khallaf

Alne-na-ei

et al. 2021

Preprint

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Imidacloprid (Imid), a systemic neonicotinoid insecticide, is broadly used worldwide. It is reported to contaminate aquatic systems. This study was proposed to evaluate oxidative stress and genotoxicity of Imid on Nile tilapia (Oreochromis niloticus) and the protective effect of ascorbic acid (Asc). O. niloticus juveniles (30.4 ± 9.3 g, 11.9 ± 1.3 cm) were divided into six groups (n=10/replicate). For 21 days, two groups were exposed to sub-lethal concentrations of Imid (8.75 ppm, 1/20 of 72h-LC50 & 17.5 ppm, 1/10 of 72h-LC50); other two groups were exposed to Asc (50 ppm) in combination with Imid (8.75 & 17.5 ppm); one group was exposed to Asc (50 ppm) in addition to a group of unexposed fish which served as controls. Oxidative stress was assessed in the liver where the level of enzymatic activities including superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) in addition to mRNA transcripts and, Lipid peroxidation (LPO) were evaluated. Moreover, mitotic index (MI) and comet assay were performed, in addition to the erythrocytic micronucleus (MN), and nuclear abnormalities (NA) were observed to assess genotoxicity in fish. Imid exposure induced significant (p˂ 0.05) changes in the antioxidant profile of the juveniles' liver by increasing the activities and gene expression of SOD, CAT and GPX as well as elevating the levels of LPO. DNA strand breaks in gill cells, erythrocytes and hepatocytes along with erythrocytic MN and NA were also significantly elevated in Imid-exposed groups. MI showed a significant (p˂ 0.05) decrease associated with Imid exposure. Asc administration induced a significant amelioration towards the Imid toxicity (8.75 & 17.5 ppm). A significant protective potency against the genotoxic effects of Imid was evidenced in Asc co-treated groups. Collectively, results highlight the importance of Asc as a protective agent against Imid-induced oxidative stress and genotoxicity in O. niloticus juveniles.

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Section: Discussionmentioning

confidence: 96%

Section: Animalsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

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Imidacloprid Induces Oxidative Stress and Genotoxicity in Nile Tilapia: The Role of Ascorbic Acid Combined Exposure

El-Garawani

Khallaf

Alne-na-ei

et al. 2021

Preprint

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“…Affects the biochemical processes and metabolites, such as the parotid and digestive glands and other metabolic active tissue [32] 11. Asian freshwater (Corbicula fluminea) 2000 µg•L −1 Causes oxidative stress, cell detoxification, and multixenobiotic resistance systems [33] 12. Neotropical fish (Prochilodus lineatus)…”

Section: Sydney Rock Oyster 2 Mg•l −1mentioning

confidence: 99%

“…However, after exposure to imidacloprid for two weeks, oysters show a proportional increase in saturated fatty acids (SFAs), a change in both polyunsaturated fatty acid (PUFA) levels and the ratio of SFAs, and a change in both the level omega 3 fatty acids (n-3) and the proportion of omega 6 fatty acids (n-6), which significantly affect the biochemical processes and metabolites of oysters, which ultimately impact food quality and safety [ 32 ]. Imidacloprid alters the oxidative stress, cell detoxification, and multixenobiotic resistance (MXR) systems of Asian freshwater Corbicula fluminea, and the mRNA expression levels of its Hsp genes (i.e., Hsp 22, Hsp 40, Hsp 60, Hsp 70, and Hsp 90) and its genes related to the M XR (i.e., abcb1 and abcc1 ) have been shown to be significantly down-regulated ( p < 0.05) [ 33 ]. Imidacloprid has also been shown to have a greater adverse effect on the brain of juvenile Chinese rare minnows ( Gobiocypris rarus ) than on that of nitipyra.…”

Section: Toxicity Of Imidaclopridmentioning

confidence: 99%

Insights into the Toxicity and Degradation Mechanisms of Imidacloprid Via Physicochemical and Microbial Approaches

Pang

Lin

Zhang

et al. 2020

Toxics

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Imidacloprid is a neonicotinoid insecticide that has been widely used to control insect pests in agricultural fields for decades. It shows insecticidal activity mainly by blocking the normal conduction of the central nervous system in insects. However, in recent years, imidacloprid has been reported to be an emerging contaminant in all parts of the world, and has different toxic effects on a variety of non-target organisms, including human beings, due to its large-scale use. Hence, the removal of imidacloprid from the ecosystem has received widespread attention. Different remediation approaches have been studied to eliminate imidacloprid residues from the environment, such as oxidation, hydrolysis, adsorption, ultrasound, illumination, and biodegradation. In nature, microbial degradation is one of the most important processes controlling the fate of and transformation from imidacloprid use, and from an environmental point of view, it is the most promising means, as it is the most effective, least hazardous, and most environmentally friendly. To date, several imidacloprid-degrading microbes, including Bacillus, Pseudoxanthomonas, Mycobacterium, Rhizobium, Rhodococcus, and Stenotrophomonas, have been characterized for biodegradation. In addition, previous studies have found that many insects and microorganisms have developed resistance genes to and degradation enzymes of imidacloprid. Furthermore, the metabolites and degradation pathways of imidacloprid have been reported. However, reviews of the toxicity and degradation mechanisms of imidacloprid are rare. In this review, the toxicity and degradation mechanisms of imidacloprid are summarized in order to provide a theoretical and practical basis for the remediation of imidacloprid-contaminated environments.

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Behavioral, Histological, and Physiological Evaluation of the Effect of Imidacloprid on the Spider Misumenops maculissparsus

Gabellone¹,

Molina

Arrighetti

et al. 2022

Enviro Toxic and Chemistry

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The aim of the present study was to evaluate the effects of the neonicotinoid insecticide imidacloprid (commercial formulation) on juveniles of the spider Misumenops maculissparsus (Keyserling, 1891). We first analyzed whether spiders recognized the presence of the insecticide on surfaces and in drinking water (in the form of droplets). Next, we investigated if the insecticide generated histologic, physiologic, and/or biochemical alterations. We observed that spiders do not detect the insecticide on a surface (e.g., paper) or in the form of droplets. After the imidacloprid ingestion by droplet intake, most spiders exhibited a paralysis that reverted after 48 h. Consequently, we observed histopathologic damage (i.e., pigment accumulation, necrosis, and cuticle detachment), and an increased catalase (CAT) activity and total-protein concentration in the individuals treated. The activities of glutathione-S-transferase, glutathione peroxidase, glutathione reductase, and superoxide dismutase, however, did not undergo significant variations. The results obtained emphasize the need to consider different classes of biomarkers, such as CAT and other proteins, to identify and evaluate the histologic, biologic, and biochemical effects of imidacloprid, one of the most widely used insecticides.

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Effect of imidacloprid on the behavior, antioxidant system, multixenobiotic resistance, and histopathology of Asian freshwater clams (Corbicula fluminea)

Cited by 69 publications

References 45 publications

Imidacloprid Induces Oxidative Stress and Genotoxicity in Nile Tilapia: The Role of Ascorbic Acid Combined Exposure

Imidacloprid Induces Oxidative Stress and Genotoxicity in Nile Tilapia: The Role of Ascorbic Acid Combined Exposure

Insights into the Toxicity and Degradation Mechanisms of Imidacloprid Via Physicochemical and Microbial Approaches

Behavioral, Histological, and Physiological Evaluation of the Effect of Imidacloprid on the Spider Misumenops maculissparsus

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