Effect of Iloprost on Impaired Anastomotic Healing Caused by 5-Fluorouracil plus Leucovorin

Vasiliadis, Konstantinos; Pramateftakis, Manousos-Georgios; Blouhos, Konstantinos; Mantzoros, Ioannis; Κολιάκος, Γεώργιος; Zaraboukas, Thomas; Kanellos, Ioannis; Demetriades, H.; Alamdari, Daryoush Hamidi; Betsis, D.

doi:10.1007/s10350-006-0878-6

Cited by 15 publications

(10 citation statements)

References 38 publications

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“…In the microscopic analysis, the muscular layer of the iloprost treated group appeared more natural as well as healthier than the colitis group. The beneficial effects of the same dose and application route of iloprost that we applied in the study had also been reported in previous studies investigating colon ischemia and anastomotic healing in Wistar albino rats (24,25).…”

Section: Discussionsupporting

confidence: 79%

“…This study presented an original idea and beneficial results were well documented in the study, however the difference of the method from the ischemia model of colon was not well defined (23,24). Ischemic colitis is difficult to evaluate experimentally, as ischemia is only one part of the complex pathogenesis of ischemic colitis (25,26). The parameter for which they evaluated utilizing microscopy could have been changed in part to the actual ischemia, rather than as a result of colitis.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Iloprost reduces colitis induced oxidative stress: An experimental study in rats

Aytaç

Teksöz²,

Saygılı³

et al. 2013

Turk J Gastroenterol

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Iloprost reduces colitis induced oxidative stress: An experimental study in rats

Aytaç

Teksöz²,

Saygılı³

et al. 2013

Turk J Gastroenterol

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“…K.Vasiliadis also used the drug intraperitoneally at the same dosage to counteract the side effects of the chemotherapeutic agents and to improve the healing of the colonic anastomoses 12 .…”

Section: Histopathological Resultsmentioning

confidence: 99%

“…The dosage was calculated by reviewing literature about the amount of iloprost that was effective on the ischemic tissue and the amount was given as a single dose after the surgery iloprost was administrated in the early period after the laparatomy to the rats in groups 1 and 3 12,13 . …”

Section: Iloprost Therapymentioning

confidence: 99%

Iloprost reduces colonic injury in ischemic colitis in rats

Karatepe¹,

Cakir²,

Ünal³

et al. 2011

Acta Cir. Bras.

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Purpose: Evaluate the effects of iloprost administration in the early period of ischemic colitis and the mechanism that how these effects develop. Methods: Thirty two Wistar albino female rats with an average weight of 220g were divided into four groups of eight rats. In group 1 the rats were given iloprost and sacrificed after 24 hours and in group 2 they were sacrificed after 24 hours without any iloprost. The rats in group 3 were administrated iloprost and sacrificed after 72 hours and in group 4 they were sacrificed at 72 th hour without iloprost. The differences between the groups as tissue damage, vascularization or apoptosis were assessed statistically. Results: Oxidative damage and apoptosis were less pronounced and vascularization was better developed in rats that were given iloprost and sacrificed at 24 th hour later in contrast to the rats that were not treated with iloprost. But there was no statistical difference among the groups at 72 th hour. Conclusion: Iloprost inhibited leucocyte infiltration, decreased proinflammatory cytokines and enhanced angiogenesis so that the oxidative stress and inflammatory response decreased resulting in lesser tissue damage. Key words: Colitis, Ischemic. Iloprost. Epoprostenol. Arachidonic Acid. Prostaglandins. Rats. RESUMOObjetivo: Avaliar os efeitos da administração de iloprosta no período precoce da colite isquêmica e o mecanismo da evolução destes efeitos. Métodos: Trinta e dois ratos Wistar fêmeas em torno de 220g foram distribuídos em quatro grupos de oito ratos. No grupo 1 administração de iloprosta e sacrificados após 24 horas; no grupo 2 foram sacrificados após 24 horas sem iloprosta; no grupo 3 foi administrado iloprosta e sacrificados após 72 horas; no grupo 4 foram sacrificados após 72 horas sem Iloprosta. As diferenças entre os grupos no referente a dano tecidual. vascularização ou apoptose foi apurada estatisticamente. Resultados: Dano oxidativo e apoptose foram menos acentuados e a vascularização foi melhor nos ratos que receberam iloprosta e sacrificados após 24 horas em contraste com os ratos que não receberam iloprosta. Porém, não houve diferença estatisticamente significante entre os grupos de 72 horas. Conclusão: Iloprosta inibe infiltração leucocitária, diminui a ação inflamatória de citoquinas e estimula angiogênese resultando em menor dano tecidual. Descritores: Colite Isquêmica. Iloprosta. Epoprostenol. Ácido Araquidônico. Prostaglandinas. Ratos.

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“…Animal models have been used extensively to study causality and underlying pathophysiological mechanisms, as well as the assessment of techniques and products that reinforce the anastomosis or improve healing. The study of anastomotic failure in animals involves moderate to severe animal discomfort, dedicated human effort and considerable cost.…”

Section: Introductionmentioning

confidence: 99%

Systematic review of experimental studies on intestinal anastomosis

Yauw

Wever

Hoesseini

et al. 2015

British Journal of Surgery

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Effect of Iloprost on Impaired Anastomotic Healing Caused by 5-Fluorouracil plus Leucovorin

Abstract: The immediate postoperative, intraperitoneal administration of iloprost counteracts and reverses the negative effects of 5-fluorouracil plus leucovorin chemotherapy and protects colonic healing in rats.

Cited by 15 publications

References 38 publications

Iloprost reduces colitis induced oxidative stress: An experimental study in rats

Iloprost reduces colitis induced oxidative stress: An experimental study in rats

Iloprost reduces colonic injury in ischemic colitis in rats

Systematic review of experimental studies on intestinal anastomosis

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