Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis

Trappe, Todd A.; White, F. Faulder; Lambert, Charles Paul; Cesar, Denise; Hellerstein, Marc K.; Evans, William J.

doi:10.1152/ajpendo.00352.2001

Cited by 241 publications

(277 citation statements)

References 37 publications

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“…Post-effort recovery acceleration and performance improvement are also related to acetaminophen consumption [17]. Another study shows that consumption of ibuprofen and acetaminophen, had attenuated the increase in muscle protein synthesis rate, that normally appear 24 hours after high-intensity eccentric resistance exercise.They haven't found other findings of acetaminopheninfluence on skeletal muscle metabolism to discuss verify or explain their results [19]. Acetaminophen can help athletes to enhance lower limbs power, but this approach for performance enhancement can be dangerous.…”

Section: Discussionmentioning

confidence: 99%

Acetaminophen effect on reaction speed and lower limbs power

Strava

Rusu

2015

Timisoara Physical Education and Rehabilitation Journal

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Background:Acetaminophen (also known as Tylenol or Paracetamol) is a very popular drug, that requires no prescription and is usually used as analgesic and antipyretic. A considerable number of previous studies show that acetaminophen has no effects that could alter exercise capacity or performance. Onthe other hand, there are studies sustaining that exercise performance can be improved with acetaminophen through a reduction in perceived pain, and also a reduction of the body heat produced by the muscle contraction.Purpose:The aim of our study was to check if acetaminophen influences reaction speed and power of the lower limbs muscles. Participants and method:For this study we recruited twenty-nine males, aged between 19 and 28 years old. We had two testing sessions for each participant, in the same day (the baseline evaluation, and the second evaluation at half an hour after acetaminophen ingestion).The evaluationsequence was: Body composition evaluation, acoustic-visual reaction test for one leg (left and right), Squad jump on one leg (5 jumps on each foot) and Stiffness test (7 jumps

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Section: Discussionmentioning

confidence: 99%

Acetaminophen effect on reaction speed and lower limbs power

Strava

Rusu

2015

Timisoara Physical Education and Rehabilitation Journal

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“…The participants then completed a series of assessments designed to establish a baseline weightlifting load that ensured momentary muscular failure after 8-12 repetitions (8-12 repetition maximum [8][9][10][11][12]). The exercises in order included in the assessment were: (1) seated chest press, (2) seated latissimus pull-down, (3) seated shoulder press, (4) leg press, (5) hamstring curl, and (6) seated knee extension.…”

Section: Visit 1 (Baseline)mentioning

confidence: 99%

“…Because high-intensity resistance exercise induces acute muscle injury and initiation of the inflammatory response, any remedy that reduces inflammation may attenuate pain and enhance physical function [1,6,20]. However, athletes seeking to implement ibuprofen or other NSAIDs into their training regimen should exercise caution, as chronic use of anti-inflammatories may inhibit muscle hypertrophy [8,20]. NSAIDs function by blocking cyclooxygenase, an enzyme necessary for achieving maximal muscle growth in response to training overload [6,20].…”

Section: Ibuprofenmentioning

confidence: 99%

“…Among these practices is the use of anti-inflammatories [1], supplementation with minerals and antioxidant vitamins [2], and higher intake of protein, carbohydrates, electrolytes, and fluids [3,4]. Anti-inflammatory medications can reduce the pain and edema that accompany training and may expedite training recovery and restoration of performance capacity [5][6][7][8]. Similarly, supplemental antioxidants carry the potential to enhance exercise performance by reducing the detrimental effects of reactive oxygen species [2,5,6].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Combined anti-Inflammatory and Nutritional Supplements on Recovery from Resistance Exercise

Baggett¹,

Cosío-Lima²,

Knapil³

et al. 2017

JSS

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This study examined the effects of combined anti-inflammatories and specific nutrients on recovery from resistance exercises. Trained individuals (n = 14) performed three sets to failure at a 8-12 repetition maximum load for six resistance exercises, then repeated this workout after 24 h. Participants consumed a protein-carbohydrate shake (330 ml; 20 g protein; 45 g carbohydrate), vitamin C (1000 mg), vitamin E (400 I.U.) and ibuprofen (100 mg) immediately after the initial workout. Another dose of vitamin C and ibuprofen were respectively consumed 1 h or 30 min before the second workout. On another occasion (counterbalanced) a placebo of flavored water, two imitation vitamins (gummy candies), and two replica ibuprofen (sugar pills) were consumed. A 10-cm visual analog scale (VAS) assessed pain, ratings of perceived exertion (RPE), and ratings of perceived recovery (RPR). Treatment enhanced performance-based recovery (repetitions after 24h) for the chest press (P < 0.010) and latissimus pull-down (P < 0.010). Within-condition comparisons revealed performance decrements (P < 0.050) after 24 h for 83% of the exercises under placebo, compared to 50% of exercises under treatment. Treatment enhanced RPR (P = 0.038) compared to placebo, but had no significant effects on residual (P = 0.215) or exercise (P > 0.050) pain. RPE was lower under the treatment for the chest press (P = 0.016) and overall workout (P = 0.038) on Day 1, but similar among all exercises on Day 2 (P > 0.050). This treatment may promote increases in performance without increasing pain or RPE.

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“…1 Although these drugs are known for their anti-inflammatory and analgesic effects there are health risks, such as an increase in gastrointestinal permeability, associated with the indiscriminate use of anti-inflammatory drugs. 12 A number of other negative side-effects have been reported for NSAIDs, including potential ulcerogenic and nephrotoxic effects and there are indications that they may inhibit protein synthesis in skeletal muscle after eccentric resistant exercise, 21 augment the exercise-induced increase in gastrointestinal permeability 12 and decrease muscle blood flow during exercise.…”

Section: Introductionmentioning

confidence: 99%

Cyclooxygenase inhibitors and the exercise-induced stress response

Claassen¹,

Snyman²,

Koorts³

et al. 2009

S Afr J SM

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The exercise-induced stress response is an adaptational homeostatic shift intended to facilitate the demands put on the body by physical exertion. Most stressors, including heat, pain, trauma and exercise, stimulate prostaglandin synthesis. The mechanisms underlying this stimulation usually involve the release of pro-inflammatory cytokines with subsequent induction of prostaglandin synthesis which influences the central neuroendocrine regulatory mechanisms.14 This stressor-induced prostaglandin synthesis, in turn, initiates and modulates many aspects of the stress response such as neuroendocrine, autonomic nervous system, metabolic and temperature changes. The pathways through which prostaglandins are involved in the cortisol stress response include a direct influence on the release of corticotropin-releasing hormone (CRH) and/or antidiuretic hormone (ADH) from the paraventricular nucleus (PVN), and indirect stimulation of the PVN via the central noradrenergic neurons. 8,14 Prostaglandins are further involved in the exercise-induced autonomic nervous system response 7 and in the increase in body temperature and other metabolic adaptations. 14 Several other aspects of the exercise-related neuroendocrine response, which are under control of the hypothalamus and the hypothalamo-pituitary axis, are also influenced by prostaglandins and other eicosanoids. 8 It therefore speaks for itself that any medication that interferes with eicosanoid metabolism could have the potential to influence the exercise-induced stress response.Eicosanoids are produced throughout the body under the influence of the cyclooxygenase (COX) activities of prostaglandin endoperoxide H synthases (PGHSs). Two PGHS isozymes exist, PGHS-1 and PGHS-2, commonly referred to as cyclooxygenase-1 or COX-1 and cyclooxygenase-2 or COX-2. COX-1 is thought to be constitutively expressed in virtually all tissues and to be Design. Eight subjects (age 20.9 ± 1.1 years, weight 70.4 ± 3.9 kg, height 170.9 ± 6.7 cm, body surface area 1.82 ± 0.09 m 2 , body mass index 24.1 ± 1.3 kg.m -2 ) took part in a double-blind, drug-placebo, cross-over design study. The experimental procedures were performed on 3 occasions on each volunteer, i.e. once on placebo, once on naproxen (single dose of 1 000 mg) and once on rofecoxib (single dose of 50 mg).results. Mean post-exercise cortisol values were significantly higher than pre-exercise values with the subjects on placebo (p = 0.0365) and rofecoxib (p = 0.0208), but not on naproxen (p = 0.0732). Post-exercise oral temperatures were significantly higher than pre-exercise temperature values on placebo (p = 0.0153) and rofecoxib (p = 0.0424), but not on naproxen (p = 0.5444).conclusion. The results of this study suggest a role for cyclooxygenase-1 (COX-1) in the exercise-induced cortisol and temperature response to exercise.

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Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis

Cited by 241 publications

References 37 publications

Acetaminophen effect on reaction speed and lower limbs power

Acetaminophen effect on reaction speed and lower limbs power

Effect of Combined anti-Inflammatory and Nutritional Supplements on Recovery from Resistance Exercise

Cyclooxygenase inhibitors and the exercise-induced stress response

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