Effect of ibandronate therapy on serum homocysteine and leptin in postmenopausal osteoporotic females

Tariq, Saba; Alam, Saadia Shahzad; Baig, Mukhtiar

doi:10.1007/s00198-014-2909-9

Cited by 17 publications

(11 citation statements)

References 35 publications

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“…In present study, serum leptin level is considerably correlated with BMI in both groups and this result is corroborated with other studies [ 2 , 11 , 19 ]. The correlation of serum leptin with the quantity of adipose tissue in PCOS has also been supported by Kazmi et al (2013) [ 20 ].…”

Section: Discussionsupporting

confidence: 93%

Serum Leptin Levels in Polycystic Ovary Syndrome and Its Relationship with Metabolic and Hormonal Profile in Pakistani Females

Baig

Rehman

Tariq

et al. 2014

International Journal of Endocrinology

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The study aimed to investigate the levels of serum leptin in PCOS females and to correlate it with metabolic and hormonal parameters. Sixty-two PCOS and ninety normal cycling (NC) females with matched age and body mass index (BMI) were recruited for this cross-sectional study. Serum leptin, FSH, LH, E2, free testosterone, progesterone, thyroid profile, and FBG levels were measured. The mean leptin levels in PCOS and NC were not significantly different (45.56 ng/mL ± 1.49 vs 41.78 ± 1.31 ng/mL, P > 0.05); however, leptin levels showed a strong correlation with BMI in PCOS and NC group (r = 0.77, P < 0.0001; r = 0.82, P < 0.0001, resp.). High E2 levels in NC had a significant correlation with leptin whereas FBG correlated with leptin in PCOS (r = 0.51, P = 0.005). TSH had a substantial correlation (r = 0.49, P < 0.005; r = 0.69, P < 0.005) in PCOS and NC, respectively. There was no significant difference found in circulating leptin concentration between PCOS and NC subjects. Leptin levels in PCOS were related with metabolic impairments manifested by disturbance in FBG levels and impairment of reproductive functions in terms of reduced E2 secretion.

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Section: Discussionsupporting

confidence: 93%

Serum Leptin Levels in Polycystic Ovary Syndrome and Its Relationship with Metabolic and Hormonal Profile in Pakistani Females

Baig

Rehman

Tariq

et al. 2014

International Journal of Endocrinology

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“…Recently, a study in Pakistan reported serum Hcy levels >15 µmol/l in elderly women that indicates Hcy level increases with age. 25 …”

Section: Discussionmentioning

confidence: 99%

Serum homocysteine level in vegetarians: are vegetarians’ at high risk of cardiovascular disease?

Kapoor¹,

Zuberi

Rathore³

et al. 2014

Pak J Med Sci

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Objectives:The aim of present study was to investigate serum homocysteine levels in apparently healthy vegetarians and ominvores in Mithi, district Tharparker, Sindh, Pakistan.Methods:This study was conducted in the Department of Biochemistry, Basic Medical Sciences Institute (BMSI), Jinnah Postgraduate Medical Center (JPMC), Karachi and blood samples were collected from Mithi, district Tharparker, Sindh, Pakistan, in 2012. One hundred vegetarian and one hundred omnivores (age ranging from 20-40 years) were enrolled for this study. Serum homocysteine levels were measured by the chemiluminescence enzyme immunoassay method.Results:Serum homocysteine (Hcy) level was considerably higher (p<0.001) in vegetarian group compared to omnivores. We further grouped and analyzed our study subjects according to their gender and according to Hcy level (greater than or lower than 15µmol/L). A considerable number of vegetarian subjects 30% were having Hcy >15µmol/L compared to omnivores 6%, (p<0.001). Gender-wise comparison showed that 27.02% male and 38.46% females had >15µmol/L serum Hcy level in vegetarian group and 6.9% male and 3.5% females had >15µmol/L serum Hcy level in omnivores group, but the difference was not significant in any group.Conclusion:Vegetarians are more prone to develop hyperhomocysteinemia, so they are at high risk to develop cardiovascular disease.

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“…Increase levels of homocysteine increases the fracture risk especially in post-menopausal females by causing oxidative damage to the bones, reducing bone quality and increasing bone resorption 10,11. Several studies have explored the relation of homocysteine with bone health in postmenopausal females,9-12 but whether physical activity also affects homocysteine levels in postmenopausal females is not completely understood.…”

Section: Introductionmentioning

confidence: 99%

Comparison of parameters of bone profile and homocysteine in physically active and non-active postmenopausal females

Tariq

Lone

Tariq³

2016

Pak J Med Sci

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Background and objectives:Optimal physical activity is important in attaining a peak bone mass. Physically active women have better bone mineral density and reduce fracture risk as compared to females living a sedentary life. The objective of this study was to compare parameters of bone profile and serum homocysteine levels in physically active and non-active postmenopausal females.Methods:In this cross sectional study postmenopausal females between 50-70 years of age were recruited and divided into two groups: Physically inactive (n=133) performing light physical activity and Physically active (n=34) performing moderate physical activity. Physical activity (in metabolic equivalents), bone mineral density and serum homocysteine levels were assessed. Spearman’s rho correlation was applied to observe correlations. Two independent sample t test and Mann Whitney U test were applied to compare groups. P-value ≤ 0.05 was taken statistically significant.Results:Parameters of bone profile were significantly higher and serum homocysteine levels were significantly lower in postmenopausal females performing moderate physical activity as compared to females performing light physical activity. Homocysteine was not significantly related to T-score and Z-score in both groups.Conclusion:Improving physical activity could be beneficial for improving the quality of bone, decreasing fracture risk and decreasing serum homocysteine levels.

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Effect of ibandronate therapy on serum homocysteine and leptin in postmenopausal osteoporotic females

Abstract: Our results show that ibandronate reduces serum leptin levels while it has no effect on serum homocysteine levels. Further studies are needed to explain how the decrease in serum leptin level may help in reducing the progression of osteoporosis.

Cited by 17 publications

References 35 publications

Serum Leptin Levels in Polycystic Ovary Syndrome and Its Relationship with Metabolic and Hormonal Profile in Pakistani Females

Serum Leptin Levels in Polycystic Ovary Syndrome and Its Relationship with Metabolic and Hormonal Profile in Pakistani Females

Serum homocysteine level in vegetarians: are vegetarians’ at high risk of cardiovascular disease?

Comparison of parameters of bone profile and homocysteine in physically active and non-active postmenopausal females

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