Effect of Terminalia chebula aqueous extract on oxidative stress and antioxidant status in the liver and kidney of young and aged rats

Abstract

We evaluated the preventive effects of Terminalia chebula (T. chebula) aqueous extract on oxidative and antioxidative status in liver and kidney of aged rats compared to young albino rats. The concentrations of malondialdehyde (MDA), lipofuscin (LF), protein carbonyls (PCO), activities of xantione oxidase (XO), manganese-superoxide dismutase (MnSOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST), and glucose-6-phosphate dehydrogenase (G6PDH), levels of glutathione (GSH), vitamin C and vitamin E were used as biomarkers. In the liver and kidney of aged animals, enhanced oxidative stress was accompanied by compromised antioxidant defences. Administration of aqueous extract of T. cheubla effectively modulated oxidative stress and enhanced antioxidant status in the liver and kidney of aged rats. The results of the present study demonstrate that aqueous extract of T. cheubla inhibits the development of age-induced damages by protecting against oxidative stress.

The development of Terminalia chebula Retz. (Combretaceae) in clinical research

“…Aqueous extract of T. chebula inhibited xanthine/xanthine oxidase activity and was also an excellent scavenger of DPPH radicals [25] . T. chebula in a polyherbal formulation (Aller-7/ NR-A2) inhibited free radical induced hemolysis and also significantly inhibited nitric oxide release from lipopolysaccharide stimulated murine macrophages [26] . Six extracts and four compounds of T. chebula fruit exhibited antioxidant activity at different magnitudes of potency [27] .…”

Phytopharmacological overview of Terminalia chebula Retz

“…5 The poly herbal formulation of T. chebula (Aller 7/ NR A2) is found to inhibit the hemolysis and makes the lipopolysaccharide to release nitric oxide in an inhibited form. 6 Acetone extract has stronger anti oxidant activity than alpha tocopherol and HPLC analysis with diode array detection indicated the presence of phenolic compounds such as hydroxybenzoic acid derivatives, hydroxyl cinnamic acid derivatives, flavonol aglycones and their glycosides. 7…”

Herbal Antioxidants as Rejuvenators in Alternative Medicine

“…Triphala is classified as a kaya karpam and has already been reported for its significant antioxidant activity (Naik et al, 2005;Hazra et al, 2010). The constituents of triphala were reported to enhance the antioxidant status in aging animal models (Yokozawa et al, 2007;Mahesh et al, 2009). In addition, triphala has been reported to possess several other important medicinal properties (Srikumar et al, 2005;Rasool and Sabina, 2007;Shi et al, 2008) that strengthen its potential to deal with multiple problems associated with aging.…”

“…Chebulagic acid isolated from Terminalia chebula has been reported to inhibit COX-2/5-LOX (Reddy et al, 2010). Apart from this, triphala has been shown to possess significant antioxidant (Naik et al, 2005;Mahesh et al, 2009;Hazra et al, 2010) and nitric oxide scavenging activity (Jagetia et al, 2004). In addition, the anti-cancer (Deep et al, 2005;Sandhya and Mishra, 2006;Shi et al, 2008), immunomodulatory (Srikumar et al, 2005) and anti-inflammatory (Rasool and Sabina, 2007) activity of triphala directly targets the common health problems associated with aging.…”