Effect of <i>São Pedro do Sul</i> thermal water on skin irritation

Ferreira, Mara; Costa, Pierre Mendes Da; Bahia, Maria Fernanda

doi:10.1111/j.1468-2494.2010.00527.x

Cited by 28 publications

(20 citation statements)

References 25 publications

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“…In contrast, Ferreira et al [74] described that some sulphurous mineral waters are anti-irritants and may help relieve skin irritation. In dermatologic formulations, they may also improve the tolerability of the products.…”

Section: Topical Transformations and Hazardsmentioning

confidence: 99%

Sulphurous Mineral Waters: New Applications for Health

Carbajo

Maraver

2017

Evidence-Based Complementary and Alternative Medicine

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Sulphurous mineral waters have been traditionally used in medical hydrology as treatment for skin, respiratory, and musculoskeletal disorders. However, driven by recent intense research efforts, topical treatments are starting to show benefits for pulmonary hypertension, arterial hypertension, atherosclerosis, ischemia-reperfusion injury, heart failure, peptic ulcer, and acute and chronic inflammatory diseases. The beneficial effects of sulphurous mineral waters, sulphurous mud, or peloids made from sulphurous mineral water have been attributed to the presence of sulphur mainly in the form of hydrogen sulphide. This form is largely available in conditions of low pH when oxygen concentrations are also low. In the organism, small amounts of hydrogen sulphide are produced by some cells where they have numerous biological signalling functions. While high levels of hydrogen sulphide are extremely toxic, enzymes in the body are capable of detoxifying it by oxidation to harmless sulphate. Hence, low levels of hydrogen sulphide may be tolerated indefinitely. In this paper, we review the chemistry and actions of hydrogen sulphide in sulphurous mineral waters and its natural role in body physiology. This is followed by an update of available data on the impacts of exogenous hydrogen sulphide on the skin and internal cells and organs including new therapeutic possibilities of sulphurous mineral waters and their peloids.

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Section: Topical Transformations and Hazardsmentioning

confidence: 99%

Sulphurous Mineral Waters: New Applications for Health

Carbajo

Maraver

2017

Evidence-Based Complementary and Alternative Medicine

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“…Neutrophil infiltration, which actively contributes to the wound healing processes, was also promoted by this bacterium through the production of TNF-α (95). It has long been known that the healing of skin irritations and skin lesions can be boosted by topical applications of spring waters where a rich presence of non-pathogenic microflora is established (96–100). In recent years, research programs have been developed to investigate the biological contents of spring waters, and their anti-inflammatory and immune protective roles.…”

Section: The Future Of Regenerative Surgerymentioning

confidence: 99%

Novel perspectives on the role of the human microbiota in regenerative medicine and surgery

et al. 2016

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Plastic surgery is transitioning from a fine craftsmanship to a regenerative science. In wound healing, the role of microorganisms is no longer considered to be just counteracting, but also promoting. Furthermore, host-microbe interactions are essential for numerous aspects of normal mammalian physiology, from metabolic activity to immune homeostasis. Each area of the human body hosts a unique microbial community, and the composition of microbiota is dependent on the host, age and the anatomical area, and it changes according to the characteristics of the microenvironment. Every squared centimeter of skin contains ~1 billion bacteria. The majority of microorganisms of the skin are commensal or temporary passing members. Skin flora mechanisms interacting or influencing the human physical skin barrier are not well defined. Resident skin bacteria provide the first line of defence against potentially dangerous pathogens and produce small molecules that influence their microbial neighbours. Furthermore, the microbiota activates and assists innate immunity and influences adaptive immunity. Various types of immune and non-immune cells contribute to wound healing. The proliferative phase of wound healing is inversely proportional to the extent of the post-traumatic inflammatory reaction. Topical bacterial lipopolysaccharide application markedly affects wound healing by accelerating the resolution of inflammation, increasing macrophage infiltration, enhancing collagen synthesis and altering the secretion of mediators involved in skin regeneration. Various studies have investigated the biological contents of thermal spring waters, and their anti-inflammatory and immune protective roles. In addition, the regenerative properties of thermal spring waters were analysed in an experimental animal wound model. The areas treated with thermal water healed faster than the areas treated with conventional dressings, and exhibited a collagen and elastic fiber network comparable with the normal skin. Thus, the microbial environment may be considered as a potential tool in regenerative medicine and surgery.

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“…Mineral medicinal waters are commonly used for the treatment of chronic dermatoses, mainly atopic dermatitis and psoriasis which are often associated with skin dryness and pruritus, increasing the quality of life and compliance in patients . The most used in dermatological thermal treatments are the sulfurous and the chlorided bromo‐iodic waters , the sulfated hypotonic ones or even bicarbonate magnesium rich in fluoride .…”

Section: Introductionmentioning

confidence: 99%