Incorporation of Cró thermal water in a dermocosmetic formulation: cytotoxicity effects, characterization and stability studies and efficacy evaluation

Nunes, Fábio Souza; Rodrigues, Márcio; Ribeiro, Maximiano P.; Ugazio, Elena; Cavalli, Roberta; Abollino, Ornella; Coutinho, Paula; Araújo, André R. T. S.

doi:10.1111/ics.12580

Cited by 10 publications

(9 citation statements)

References 31 publications

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“…Namely, thermal spring waters are associated with a wide range of therapeutic value such as anti-inflammatory, detergent, anti-pruriginous, keratoplastic, or antioxidant (Araujo et al, 2015). These kinds of waters also promote the control of skin hydration level, which is one of the most relevant bioindicators of the skin health (Nunes et al, 2019). An important source of these thermal and mineral waters is the Ourense province (Northwest of Spain), whose high thermal flow makes it the second city in Europe.…”

Section: Introductionmentioning

confidence: 99%

“…The thermo-mechanical properties of the biopolymer-based hydrogels are also highly dependent on the employed liquid phase, mainly when solvent with high mineral content are employed (Mao et al, 2020;Moreira et al, 2011;Priedniece et al, 2017). Consequently, the incorporation of mineral thermal waters on the formulation of starchy hydrogels could notably modify the texture and stability of the matrix (Lee & Lee, 2018;Nunes et al, 2019;Tai et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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The key role of thermal waters in the development of innovative gelled starch-based matrices

et al. 2021

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The key role of thermal waters in the development of innovative gelled starch-based matrices

et al. 2021

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“…This composition is responsible for promoting cellular renewal, skin hydration, recovery of cutaneous barrier function and keratolytic effects. In addition, it has been demonstrated that this water possesses antimicrobial, antioxidant and anti-inflammatory activities [23][24][25]. The potential of thermal water has been explored by different cosmetic companies, especially French ones, providing scientific evidence, through in vitro and in vivo studies, of the value of thermal water for the mentioned skin conditions, as recently reviewed [26,27].…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of Thermal Water Gel Comprising Helichrysum italicum Essential Oil-Loaded Chitosan Nanoparticles for Skin Care

et al. 2023

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Helichrysum italicum essential oil (H. italicum EO) is recognized for its anti-inflammatory, antimicrobial and wound-healing properties. The main goal of the present work was the development and characterization of a gel formulation comprising H. italicum EO loaded in chitosan nanoparticles (NPs) for dermatological applications. H. italicum EO-loaded chitosan NPs presented hydrodynamic diameter and PdI of about 300 nm and 0.28, respectively, and a surface charge of +19 mV. The H. italicum EO-loaded chitosan NPs were prepared by means of ionic gelation and then incorporated into a thermal water gel formulation. The organoleptic and physicochemical properties of the developed gel were studied. The gel remained stable under accelerated test conditions, maintaining pH, viscosity and organoleptic properties. In addition, the formulation presented pH, viscosity and spreadability properties suitable for topical application. Finally, the performance of the gel in topical application was evaluated on the skin of volunteers using non-invasive methods, particularly, by means of biometric evaluation. These assays showed that the properties of the developed thermal water-based gel formulation with H. italicum EO-loaded chitosan NPs can improve skin hydration and maintain healthy skin conditions, demonstrating its putative role for distinct dermatological applications.

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“…Numerous studies have also used cell culture to determine the molecular mechanisms of TWs action at cutaneous level (Dal Pra, Chiarini et al 2007, Joly, Branka et al 2014, Karagülle, Karagülle et al 2018. Furthermore, thermal waters were successfully included as raw materials for dermocosmetic formulations to achieve the cutaneous welfare (Almeida, Madeira et al 2019, Nunes, Rodrigues et al 2019, Tan, Spada et al 2020.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effects of free and liposome-encapsulated Algerian thermal waters in RAW 264.7 macrophages

Mokdad

Seguin

Fournel

et al. 2022

International Journal of Pharmaceutics

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The main objectives of this work were to formulate liposomes encapsulating highly mineralized thermal waters (TWs) and to study the potential anti-inflammatory effect of free and encapsulated thermal waters on RAW 264.7 macrophage cells stimulated with lipopolysaccharide (LPS). TWsloaded conventional and deformable liposomes (TWs-Lip and TWs-DLip) were prepared by sonication and extrusion, respectively. They were characterized for their vesicle size, zeta potential, entrapment efficiency, physical stability and in vitro anti-inflammatory effect. Formulated suspensions have a low polydispersity and nanometric size range with zeta potential values closed to zero. The vesicle size was stable for 30 days. Entrapment efficiency of TWs in conventional and deformable liposomes was found to be higher than 90% and 70%, respectively. Pretreatment of LPS-stimulated murine macrophages with TWs resulted in a significant reduction in NO production and modulated TNF-α production suggesting an anti-inflammatory effect which were even more striking with TWs-Lip and TWs-DLip. Liposome formulations may offer a suitable approach for transdermal delivery of TWs indicated in inflammatory skin diseases.

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Incorporation of Cró thermal water in a dermocosmetic formulation: cytotoxicity effects, characterization and stability studies and efficacy evaluation

Abstract: CONCLUSION: Cette etude a d emontr e pour la premi ere fois les avantages potentiels de l'eau thermale de Cr o dans une formulation de gel destin ee aux applications cosm etiques et dermatologiques.Thermal water-based gel dermocosmetic formulation F. Nunes et al.

Cited by 10 publications

References 31 publications

The key role of thermal waters in the development of innovative gelled starch-based matrices

The key role of thermal waters in the development of innovative gelled starch-based matrices

Development and Characterization of Thermal Water Gel Comprising Helichrysum italicum Essential Oil-Loaded Chitosan Nanoparticles for Skin Care

Anti-inflammatory effects of free and liposome-encapsulated Algerian thermal waters in RAW 264.7 macrophages

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