Effect ofRheedia longifoliaLeaf Extract and Fractions on the P2X7ReceptorIn Vitro: Novel Antagonists?

Santos, José Augusto Albuquerque dos; Fidalgo-Neto, Antônio Augusto; Faria, Robson Xavier; Simões, Ana; Calheiros, Andrea Surrage; Bérenger, Ana Luíza Rangel; Faria-Neto, Hugo; Figueiredo, Maria Raquel; Frutuoso, Valber S.; Alves, Luiz Anastácio

doi:10.1089/jmf.2010.0184

Cited by 16 publications

(15 citation statements)

References 34 publications

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“…The leaves aqueous extract of Rheedia longifolia inhibited inflammation six hours after the intrathoracic administration of LPS in the pleural wash recovered from LPS-injected mice [29]. …”

Section: Resultsmentioning

confidence: 99%

“…In addition, the aqueous crude extract also shows antinociceptive activity similar to that of an opioid agonist [29]. The Rheedia genus is characterized by the presence of triterpenes, steroids, coumaric acid, xanthones, and benzophenones and it is interesting that only the butanol and aqueous fractions inhibited inflammatory nociception, a characteristic of Arylpropanoids that is not observed in the dichloromethane and ethyl acetate fractions.…”

Section: Resultsmentioning

confidence: 99%

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A Systematic Review for Anti-Inflammatory Property of Clusiaceae Family: A Preclinical Approach

Melo

Quintans

Araújo

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Background. Clusiaceae family (sensu lato) is extensively used in ethnomedicine for treating a number of disease conditions which include cancer, inflammation, and infection. The aim of this review is to report the pharmacological potential of plants of Clusiaceae family with the anti-inflammatory activity in animal experiments. Methods. A systematic review about experiments investigating anti-inflammatory activity of Clusiaceae family was carried out by searching bibliographic databases such as Medline, Scopus and Embase. In this update, the search terms were “anti-inflammatory agents,” “Clusiaceae,” and “animals, laboratory.” Results. A total of 255 publications with plants this family were identified. From the initial 255 studies, a total of 21 studies were selected for the final analysis. Studies with genera Allanblackia, Clusia, Garcinia or Rheedia, and Hypericum showed significant anti-inflammatory activity. The findings include a decrease of total leukocytes, a number of neutrophils, total protein concentration, granuloma formation, and paw or ear edema formation. Other interesting findings included decreased of the MPO activity, and inflammatory mediators such as NF-κB and iNOS expression, PGE2 and Il-1β levels and a decrease in chronic inflammation. Conclusion. The data reported suggests the anti-inflammatory effect potential of Clusiaceae family in animal experiments.

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“…The leaves aqueous extract of Rheedia longifolia inhibited inflammation six hours after the intrathoracic administration of LPS in the pleural wash recovered from LPS-injected mice [29]. …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A Systematic Review for Anti-Inflammatory Property of Clusiaceae Family: A Preclinical Approach

Melo

Quintans

Araújo

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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“…Its key role makes it an important anti-inflammatory target [50], not to mention a potential therapeutic pain target, and it has received attention from pharmaceutical companies that are evaluating clinical trials based on it. Recently the antagonistic effect of bisflavonoids from the methanolic extract fractions of Rheedia logifolia on the P2X7R has been found to promote analgesic action on inflammatory pain [51]. …”

Section: Natural Products and Their Potential As Modulators Of Thementioning

confidence: 99%

Natural Products as a Source for New Anti-Inflammatory and Analgesic Compounds through the Inhibition of Purinergic P2X Receptors

Soares‐Bezerra

Calheiros²,

Ferreira³

et al. 2013

Pharmaceuticals

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Natural products have reemerged in traditional medicine as a potential source of new molecules or phytomedicines to help with health disorders. It has been established that members of the P2X subfamily, ATP-gated ion channels, are crucial to the inflammatory process and pain signalization. As such, several preclinical studies have demonstrated that P2X2R, P2X3R, P2X4R and P2X7R are promising pharmacological targets to control inflammatory and pain disorders. Several studies have indicated that natural products could be a good source of the new specific molecules needed for the treatment of diseases linked to inflammation and pain disorders through the regulation of these receptors. Herein, we discuss and give an overview of the applicability of natural products as a source to obtain P2X receptors (P2XR) selective antagonists for use in clinical treatment, which require further investigation.

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“…However, natural products are also valuable sources due to their biological richness and chemical structure diversity (Hong, ; Koehn & Carter, ). Moreover, there are some compounds from natural products described in the literature that have antagonistic activity toward P2X7R, such as amentoflavone from Rheedia longifolia Planch & Triana and emodin from Rhein officinale Baill (Liu, Zou, Liu, Jiang, & Li, ; Santos et al, ).…”

Section: Introductionmentioning

confidence: 99%

A new insight into purinergic pharmacology: Three fungal species as natural P2X7R antagonists

Soares‐Bezerra

Ferreira

Alves

et al. 2019

Phytotherapy Research

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P2X7 is a purinergic receptor involved in important physiological functions and pathological processes, such as inflammation, neurodegeneration, and pain. Despite its relevance, there is no selective antagonist useful in the treatment of diseases related to this receptor. In this context, research for a selective, safe, and potent antagonist compound that can be used in clinical therapy has been growing. In this work, we evaluated the potential antagonistic activity of three fungal extracts, namely, Vishniacozyma victoriae, Metschnikowia australis, and Ascomycota sp., which were discovered in a high‐throughput screening campaign to search for new antagonists for P2X7R from natural products. First, the IC50 values of these fungal extracts were determined in J774.G8 (murine macrophage cell line) and U937 (human monocyte cell line) cells through dye uptake assays. The IC50 values of V. victoriae were 2.6 and 0.92 μg/mL, M. australis has IC50 values of 3.8 and 1.5 μg/mL, and Ascomycota sp. showed values of 2.1 and 0.67 μg/mL in J774.G8 and U937 cells, respectively. These extracts also significantly inhibited propidium iodide and Lucifer yellow uptake via P2X7R pore, P2X7R currents in electrophysiology, IL‐1β release, and the production of oxide nitric and reactive oxygen species. The extracts did not cause cytotoxicity within a period of 24 h. The results showed the promising antagonistic activity of these extracts toward P2X7R, thereby indicating that they can be future candidates for phytomedicines with potential clinical applicability.

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Effect ofRheedia longifoliaLeaf Extract and Fractions on the P2X₇ReceptorIn Vitro: Novel Antagonists?

Cited by 16 publications

References 34 publications

A Systematic Review for Anti-Inflammatory Property of Clusiaceae Family: A Preclinical Approach

A Systematic Review for Anti-Inflammatory Property of Clusiaceae Family: A Preclinical Approach

Natural Products as a Source for New Anti-Inflammatory and Analgesic Compounds through the Inhibition of Purinergic P2X Receptors

A new insight into purinergic pharmacology: Three fungal species as natural P2X7R antagonists

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