Effect ofPiper betleon plasma antioxidant status and lipid profile against D-galactosamine-induced hepatitis in rats

Abstract

Betle leaf chewing is an old traditional practice in India and other countries of East Asia. We have investigated the antioxidant and antihyperlipidaemic potential of an alcoholic leaf-extract of Piper betle against D-galactosamine (D-GalN; 400 mg/kg body weight, i.p. single dose) intoxication in male albino Wistar rats. Rats were treated with leaf-extract (200 mg/kg body weight) by intragastric intubations daily for 20 days. The animals were divided randomly into five groups of six animals each as control, control plus extract, D-GalN control, D-GalN-rats on treatment with extract or silymarin, a standard drug. We observed an increase in the plasma levels of thiobarbituric acid reactive substances (TBARS), lipid hydroperoxides, and a decrease in vitamin C, vitamin E and reduced glutathione concentrations. Very low density lipoprotein cholesterol and low density lipoprotein cholesterol increased significantly while high density lipoprotein cholesterol decreased. Further, increase in the levels of total cholesterol, phospholipids, triglycerides, free fatty acids in the plasma and tissues of liver and kidney were observed in D-GalN-treated rats. Administration of P. betle leaf-extract prevented the increase or decrease of these parameters and brought towards normality. These results suggest that P. betle could afford a significant antioxidant and antihyperlipidaemic effect against D-GalN-intoxication.

Lycopene stabilizes lipoprotein levels during D-galactosamine/lipopolysaccharide induced hepatitis in experimental rats

“…Therefore the decreased HDL levels in D-GalN/LPS-induced rats might be due to the reduced activities of LPL and LCAT [44] . Numerous studies have already reported the increased levels of LDL, VLDL and concomitant reduction in the HDL values during GalN/LPS induced liver injury [2,[47][48][49] . Our present findings clearly match with the above findings.…”

Salivary ascorbic acid levels in betel quid chewers: A biochemical study

“…[8] Another recent study revealed unaltered levels of serum ascorbic and Vitamin E in experimental rats administered with betel leaf extract and challenged with hepatotoxic substance. [9] Similar methods were used in our study although no drug interventions were made to the study subjects. In our study subjects were divided into two groups based on the use of betel leaf in their quid chewing habit.…”

Protective Effects of Moutan Cortex Radicis against Acute Hepatotoxicity

“…Many environmental toxins cause liver injury to humans; despite new advances in hepatology, treatment of liver disease does not resolve the problems caused by these toxins. Furthermore, despite considerable progress in treatment of liver disease by oral hepatoprotective agents, the search for newer drugs continues due to the limitations of existing synthetic drugs (Pushpavalli et al, 2009). Therefore, there has been considerable interest in the role of complementary and alternative medicines for treatment of liver diseases.…”