Effect of <i>Momordica charantia</i> on lipid proﬁle and oral glucose tolerance in diabetic rats

Chaturvedi, Padmaja; George, Santosh; Milinganyo, M.; Tripathi, Yamini B.

doi:10.1002/ptr.1589

Cited by 64 publications

(34 citation statements)

References 8 publications

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“…Oral glucose tolerance tests were carried out during the last week of experimentation, following the method described by Chaturvedi et al (2004). To perform OGTT, rats in groups 1 and 4 were fasted overnight and the next day, blood samples were collected from the tail vein of each rat just before (0 h) glucose administration and at 30 min, 60 and 120 min respectively after glucose administration (3 g/kg).…”

Section: Oral Glucose Tolerance Test (Ogtt)mentioning

confidence: 99%

Dietary intake of boiled breadfruit (Treculia africana) seeds did not improve hyperglycemia in streptozotocin induced diabetic rats: Effect on the oral glucose tolerance of normoglycemic rats

Eleazu

Ezekwibe

Egbe

et al. 2017

Acta Sci Pol Technol Aliment

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Diabetes mellitus is a global health problem that is causing problems for humans around the world and becoming increasingly prevalent at an alarming rate (Aloulou et al., 2012), including amongst the rural Nigerian population. The inability of modern treatments to control all the pathophysiological aspects of diabetes, as well as the enormous cost it imposes on the economy of the developing nations of the world, ABSTRACTBackground. Although African breadfruit (Treculia africana) is said to be useful in the dietary management of diabetes, the effect of cooking on its glycemic index has not been reported. Hence this study has investigated the effect of a dietary intake of boiled breadfruit on the serum glucose, glucose tolerance, body weights and relative organ weights of streptozotocin (STZ) induced diabetic rats. Materials and methods. Twenty albino rats were used and were divided into four groups of five rats. Groups 1 (normal control) and 2 (diabetic control) received standard rat pellets while groups 3 (diabetic-test group) and 4 (non-diabetic) rats received breadfruit. Results. The blood glucose of the normoglycemic rats fed standard rat feeds peaked at 30 min (149.75 ±11.12 mg/dl) following oral glucose loading (3 g/kg) but reduced to 85.25 ±21.05 mg/dl after another 90 min, while the blood glucose of the normoglycemic rats fed breadfruit peaked at 30 min (146.25 ±15.22 mg/dl) following oral glucose loading, but elevated (130.75 ±36.69 mg/dl) after another 90 min. There was significant elevation (P < 0.05) of the serum glucose, relative liver weight (RLW) and relative kidney weight (RKW) but a significant decrease in the body weights of the diabetic control compared with the normal control; no significant difference (P > 0.05) in the serum glucose, body weights, RLW and RKW of the test group compared with the diabetic control, and no significant differences (P > 0.05) in the serum glucose, body weights, RLW and RKW of the normal rats fed the breadfruit diet compared to the normal control. Conclusion. The study showed that the traditional method of cooking African breadfruit negatively affects its hypoglycemic property.

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Section: Oral Glucose Tolerance Test (Ogtt)mentioning

confidence: 99%

Dietary intake of boiled breadfruit (Treculia africana) seeds did not improve hyperglycemia in streptozotocin induced diabetic rats: Effect on the oral glucose tolerance of normoglycemic rats

Eleazu

Ezekwibe

Egbe

et al. 2017

Acta Sci Pol Technol Aliment

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“…Momordicine, a bitter glucoside, is an alkaloid, concentrated in the fruits of M. charantia 5 , the extracts of which possess anti-diabetic activity 16 .…”

Section: Discussionmentioning

confidence: 99%

CHARACTERIZATION OF MOLLUSCICIDAL COMPONENT OF Moringa oleifera LEAF AND Momordica charantia FRUITS AND THEIR MODES OF ACTION IN SNAIL Lymnaea acuminata

Upadhyay

Singh

2013

Rev. Inst. Med. trop. S. Paulo

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SUMMARYThe molluscicidal activity of the leaf powder of Moringa oleifera and lyophilized fruit powder of Momordica charantia against the snail Lymnaea acuminata was time and concentration dependent. M. oleifera leaf powder (96 h LC 50 : 197.59 ppm) was more toxic than M. charantia lyophilized fruit powder (96 h LC 50 : 318.29 ppm). The ethanolic extracts of M. oleifera leaf powder and Momordica charantia lyophilized fruit powder were more toxic than other organic solvent extracts. The 96 h LC 50 of the column purified fraction of M. oleifera leaf powder was 22.52 ppm, while that of M. charantia lyophilized fruit powder was 6.21 ppm. Column, thin layer and high performance liquid chromatography analysis show that the active molluscicidal components in M. oleifera leaf powder and lyophilized fruit of M. charantia are benzylamine (96 h LC 50 : 2.3 ppm) and momordicine (96 h LC 50 : 1.2 ppm), respectively. Benzylamine and momordicine significantly inhibited, in vivo and in vitro, the acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissues of L. acuminata. Inhibition of AChE, ACP and ALP activity in the nervous tissues of L. acuminata by benzylamine and momordicine may be responsible for the molluscicidal activity of M. oleifera and M. charantia fruits, respectively.

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“…En plus de son utilisation antidiabétique, la plante possède d'autres propriétés pharmacologiques telles que, antibactérienne, antivirale et anti-ulcère [6,15,17], elle améliore le fonctionnement du pancréas [1,22], le foie [18] et le muscle squelettique [18,27]. Les extraits de cette plante sont capables de restaurer les paramètres sanguins et hépatiques à leurs niveaux normaux chez les rats diabétiques [8,11]. Il a été aussi rapporté que le jus de fruit de cette plante possède une activité antiradicalaire [23].…”

Section: Introductionunclassified

Validation et contribution à l’étude de l’effet antihyperglycémique d’une plante médicinale, le Momordica charantia L.

et al. 2009

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Ré sumé : Momordica charantia (L.) [Cucurbitaceae], connu sous le nom de concombre amer ou karela, est une plante alimentaire et médicinale, utilisée en Ayurveda pour le traitement de différentes maladies, dont le diabète. Dans cette étude, l'activité antihyperglycémique du fruit de cette plante a été démontrée chez les souris rendues diabétiques par l'alloxane monohydrate. Deux extraits de fruits frais et secs ont été préparés, et leurs effets sur le taux de glucose sanguin ont été comparés à une molécule antidiabétique de référence, la glibenclamide. L'extrait aqueux du fruit frais à la dose de 200 mg/kg a montré une diminution significative de la glycémie (62 %), un effet comparable à celui obtenu par la glibenclamide à la dose de 10 mg/kg. Les deux extraits à différentes doses n'ont pas montré de signe de toxicité. Ainsi, l'extrait aqueux de Momordica charantia, une plante comestible, semble être une alternative sûre à la réduction de la glycémie et un traitement auxiliaire et complémentaire pour limiter les effets secondaires des traitements allopathiques avec les médicaments synthétiques.A study of the anti-hyperglycaemic effects of the medicinal plant, Momordica charantia L.: validation and contribution Abstract: Momordica charantia (L.) [Cucurbitaceae], more commonly known as the bitter cucumber or bitter melon, is a plant used for food and medicine. In the Ayurvedic tradition it is used to treat a range of disorders, including diabetes. This study has demonstrated the plant's antihyperglycaemic effect in mice with alloxan monohydrate induced diabetes. Two extracts were prepared, from both the fresh and the dried fruit of the plant, and their effects on blood sugar levels were compared with the reference anti-diabetes molecule glibenclamide. Aqueous extract of the fresh fruit at a dose of 200 mg/kg demonstrated a significant reduction in glycemia (62%), comparable with that of glibenclamide at a dose of 10 mg/kg. The two extracts at different doses showed no signs of toxicity. Thus, aqueous extract of the edible plant M. charantia would appear to be a viable alternative for reducing glycemia as well as providing an auxiliary and complementary treatment which would limit the secondary effects of allopathic remedies using synthetic drugs.

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Effect of Momordica charantia on lipid proﬁle and oral glucose tolerance in diabetic rats

Cited by 64 publications

References 8 publications

Dietary intake of boiled breadfruit (Treculia africana) seeds did not improve hyperglycemia in streptozotocin induced diabetic rats: Effect on the oral glucose tolerance of normoglycemic rats

Dietary intake of boiled breadfruit (Treculia africana) seeds did not improve hyperglycemia in streptozotocin induced diabetic rats: Effect on the oral glucose tolerance of normoglycemic rats

CHARACTERIZATION OF MOLLUSCICIDAL COMPONENT OF Moringa oleifera LEAF AND Momordica charantia FRUITS AND THEIR MODES OF ACTION IN SNAIL Lymnaea acuminata

Validation et contribution à l’étude de l’effet antihyperglycémique d’une plante médicinale, le Momordica charantia L.

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