Effect of Helicobacter pylori infection on vitamin D levels in old patients with sarcopenia

Abstract

We aimed to determine the possible relationship between sarcopenia, Helicobacter pylori and 25‐OH vitamin D. A total of 101 patients aged 65 years and over were included in the study, and grouped as sarcopenia (+) and (−) according to the skeletal muscle index (SMI) measured by bioelectrical impedance analysis (BIA). Also, patients were divided into two groups according to the presence and absence of H. pylori infection. There was no significant difference in the frequency of H. pylori infection in patients with and without sarcopenia (37.0% vs 29.7%; P = .485); 25‐OH vitamin D levels were significantly lower (18.25 [6.20‐32.00] μg/L vs 26.30 [9.33‐50.00] μg/L; P < .05) and the frequency of vitamin D deficiency (<20 μg/L) was significantly higher (80.0% vs 29.4%; P < .05) in sarcopenic patients with H. pylori infection than those without H. pylori infection. In addition, H. pylori infection was found to be associated with vitamin D deficiency in patients with sarcopenia (odds ratio: 12.53[1.48‐105.87]; P < .05). Within these findings, we concluded that the presence of H. pylori infection may lead to vitamin D deficiency in patients with sarcopenia.

Vitamin D and Its Association with H. pylori Prevalence and Eradication: A Comprehensive Review

“…Furthermore, one study conducted in Bahrain highlighted that, for each unit decrease in serum vitamin D level, the risk of H. pylori infection increases by 1.1 [ 25 ]. In a study conducted on an older population with sarcopenia, an inverse relationship between vitamin D deficiency and H. pylori was proposed, suggesting that H. pylori might actually be the risk factor for vitamin D level decrease [ 28 ]. However, Bashir et al proved on a limited population sample that an 8-week supplementation regimen of high oral vitamin D3 doses can significantly decrease H. pylori colonization of the gastric mucosa.…”

“…Hence, future prospective studies and randomized controlled trials are required to clarify the relationship between vitamin D serum levels, its supplementation, and H. pylori, and to evaluate whether the addition of vitamin D3 to therapeutic regimens influences bacterial eradication. Cofounding factors such as age, interfering in the relationship between vitamin D supplementation and H. pylori prevalence and eradication, are also subject to future debate, given the lack of regular vitamin D intake among adult populations and the possible inverse relationship between H. pylori and vitamin D deficiency, as proposed by Bahși et al [ 28 ].…”

The Effects of Vitamins and Micronutrients on Helicobacter pylori Pathogenicity, Survival, and Eradication: A Crosstalk between Micronutrients and Immune System

“…Concerning adults, Shafrir et al demonstrated that vitamin D was inversely related to H. pylori infection and the possibility of infection was significantly higher in vitamin D-deficient patients than vitamin D-sufficient patients [ 105 ]. A recent study similarly reported that in the old patients, aged 65 years, with sarcopenia, H. pylori infection led to vitamin D deficiency and the prevalence of infection was significantly higher in vitamin D-deficient patients [ 106 ]. Twenty years of 1 α -hydroxyvitamin D3 supplementation resulted in a significantly lower H. pylori infection rate in subjects [ 107 ].…”