Effect of Helicobacter pylori eradication on elder cases: Observational study in community-based medicine

Abstract

AIMTo examine the effect of Helicobacter pylori (H. pylori) eradication therapy on the extra-gastrointestinal factors in elderly patients by a before-after observational study in community medicine.METHODSMedical records (1 May 2013-31 January 2014) of 130 patients who underwent H. pylori eradication therapy with 2-year after-eradication observation in our institute were reviewed. Data on sex; age; body weight; body mass index (BMI); mean corpuscular volume (MCV); total protein; low-density lipoprotein cholesterol, triglyceride, haemoglobin A1c and haemoglobin levels and gastric hyperplastic polyps (GHPs) at eradication was extracted. Two-year after-eradication change in data was analysed by paired-sample t-test; relationship between GHPs and subclinical iron deficiency anaemia (IDA) improvement was evaluated.RESULTSThe mean patient age (median, interquartile range) at eradication was 69.6 (71.5, 64-77) years. Paired-sample t-tests showed that body weight, BMI and MCV increased by 0.52 kg (P = 0.018), 0.25 kg/m2 (P = 0.006) and 0.83 fL (P < 0.001), respectively. The nonparametric Mann-Whitney test showed no significant difference in the change rate of MCV after eradication between the groups with and without GHPs (P = 0.892).CONCLUSIONH. pylori eradication therapy prevented weight loss and subclinical IDA in elderly individuals. GHPs were not associated with subclinical IDA.

Effect of Helicobacter pylori Eradication on Body Weight: A Multicenter Propensity Score-matched Analysis in Korea

“…20 Several epidemiological studies focusing on the correlation between H. pylori colonization and BMI and obesity have shown contrasting results. 1,2,13,15,[21][22][23][24][25] A study from the Netherlands showed no evidence supporting a clinically relevant association between H. pylori and BMI/obesity, but a small negative association with obesity was present. 25 In a prospective randomized study of 1558 H. pylori-infected patients conducted in 2011, the BMI increased significantly after 6 months following randomization to H. pylori eradication therapy.…”

“…There is a definite need for a more focused analysis in the future, especially among patients showing sarcopenia or cachexia. Considering a Chinese study of elderly individuals, 15 HPE therapy could prevent further weight loss in those with sarcopenia or frailty. Among patients with the highest baseline BMI, the change in BMI after HPE was minimal (mean change [SD], We also performed stratified analyses for baseline age and sex and tested for the interaction effects.…”

“…14 In a study among elderly people, HPE was significantly associated with elevated BMI. 15 However, the presence of active ulcers was not controlled in the patients in these studies, 14,15 and 1 study did not compare the HPE group with non-HPE controls. 15 The purpose of this study is to analyze the impact of HPE on BMI.…”

“…15 However, the presence of active ulcers was not controlled in the patients in these studies, 14,15 and 1 study did not compare the HPE group with non-HPE controls. 15 The purpose of this study is to analyze the impact of HPE on BMI. The secondary outcome is any change in the lipid profile after HPE.…”

Helicobacter pylori and extragastric diseases

“…In fact, they reported a higher expression of sialic acid‐binding ( sab ) gene and vacuolating cytotoxin gene A ( vac A) in patients with IDA compared to healthy subjects . Maruyama et al clearly demonstrated how H. pylori eradication is able to decrease weight loss and prevent subclinical IDA in older subjects …”