Effect of Calendula arvensis extract on anti-melanogenesis and antimicrobial activity

Abstract

At concentrations with little or no cytotoxicity, C. arvensis extract indicates the ability of high DPPH radical scavenging, inhibited tyrosinase activity, and decreased melanin content. The treatment of B16F10 cells with C. arvensis extract suppressed the protein expression of tyrosinase a dose-dependent manner. These results suggest that C. arvensis extract inhibits melanin synthesis by inhibiting tyrosinase expression and tyrosinase activity. In addition, C. arvensis extract showed antimicrobial activities against bacteria and yeast. These results indicate that C. arvensis extract may serve as nutraceutical and cosmeceutical agents.

Traditional Uses, Bioactive Compounds, and Pharmacological Investigations of Calendula arvensis L.: A Comprehensive Review

“…In contrast, it has been reported that C. arvensis extract is a safe natural product, as at least it did not induce any cytotoxicity at 100 μ g/mL. The cytotoxicity of this extract was 0, 0.1, 0.3, 15.1, and 28.0% at increasing concentrations of 10, 100, 250, and 500 μ g/mL, respectively [ 104 ].…”

“…Interestingly, all extracts displayed good antituberculosis effects against M. smegmatis with MIC between 13.2 and 62.5 μ g [ 41 ]. According to Kim [ 104 ], C. arvensis extract had excellent antibacterial activity, and after 12 hours of culture, it inhibited the growth of B. subtilis , E. coli , and C. albicans by 40, 7, 35.2, and 27.5%, respectively. Moreover, the growth inhibitory effect against the positive bacteria, B. subtilis , was the highest.…”

“…The total antioxidant capacity ranged from 42 to 48.4 μ mol TE/g DW for the methanolic and aqueous extracts, respectively [ 97 ]. Kim [ 104 ] showed that the DPPH scavenging activity of C. arvensis extract samples at concentrations of 10, 50, and 100 μ g/mL showed almost the same radical scavenging activity as the control (ascorbic acid) (88.9, 91.2, and 91.3%). Lee et al [ 106 ] showed that with high DPPH free radical scavenging activity, the possibility of using C. arvensis flower extracts as a natural antioxidant was high.…”