Effect of Artemisia extract on glycemic control: A systematic review and meta‐analysis of randomized controlled trial

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by elevated blood glucose levels because of a lack of insulin secretion or insulin resistance. 1 Based on International Diabetes Federation reports, 415 million adult subjects have DM around the world and the trend is ascending. 2 DM complications are categorized into the micro and macro vascular damages and can affect the heart, kidney, eyes and nerves. 3 Besides critical complications, DM can cause financial burden and decrease quality of life. 4 The global economic burden of DM was about US$ 1.31 trillion, or 1.8% of the global gross domestic product in 2015; the medical costs accounted for two-thirds of these costs. 5 Nowadays, the use of traditional and folklore medicines for prevention and control of diseases has increased. Widespread claims and advertisements about medicinal plants inspire patients to rush towards this kind of medications. In comparison to chemical drugs, medicinal plants have fewer side-effects and produce a greater sense of satisfaction in patients. Hence, patients with DM seek for herbal medicines to enable them to reduce the dosage of their hypoglycaemic medications or help them to get rid of the medications. 6 However, evidence-based research is needed to evaluate the usefulness and efficacy of these plants in clinical settings and determine if such treatments could be used in place of approved drugs. Among herbal medicines, there are plants that are valuable sources of anti-diabetic agents such as alkaloids, flavonoids and tannins that affect pancreatic β-cells' activity, increase insulin secretion, or decrease the intestinal absorption of glucose. 7,8 Artemisia is a wide genus of plants with 200-400 species belonging to the daisy family Asteraceae. 9 Animal and human trials reported hypoglycaemic

Effectiveness of Jena DM® Herbal Formulation as Complementary Therapy to Conventional Oral Hypoglycemic Agents in Type-2 Diabetes Mellitus: A Quasi-experimental Study

“…However, this study did not demonstrate a statistically significant difference in 12-week glycemic control between study groups. In their review, Sasani et al concluded that complementary therapy with different Artemisia extracts significantly improved insulin resistance (HOMA2-IR), but benefits in glycemic control remained unclear [16]. Extracts of Artemisia spp have diverse secondary metabolites [17], and the majority of the known potent anti-hyperglycemic phytochemical compounds, i.e., flavonoids, coumarins, and essential oils, are largely abundant in a few Artemisia spps like A. drancunculus and A. princeps [18].…”

The effect of acorn muffin consumption on glycemic indices and lipid profile in type 2 diabetic patients: A randomized double‐blind placebo‐controlled clinical trial

“…TA B L E 6 Appetite indices and dietary intake before and after the study clinically important. Studies of Dogan et al (Dogan et al, 2015) and Shaheen et al (Shaheen et al, 2017) reveal an improvement in levels of HDL, LDL, TC, and TG, where the higher Quercus extract doses yielded better improvements. The abovementioned studies suggested that the mechanism could be associated with the decrement in cholesterogenesis and synthesis of fatty acid, and may be related to the amelioration in glucose and insulin levels.…”

“…Further, the greater the amount of Quercus extract level, the better the observed glycemic improvement (Dogan et al, 2015). Also, Shaheen et al (Shaheen et al, 2017) reported the positive effects of the Q. dilatata extract on blood glucose levels of diabetic rats.…”

“…Moreover, in-vivo and in-vitro investigations have shown hypoglycemic properties of acorn extract, such as α-amylase inhibition, and positive effects of acorn on DM complications (Dogan et al, 2015;Shaheen et al, 2017).…”

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Despite the presence of various approaches for controlling diabetes mellitus (DM), such as dietary adjustment (Asif, 2014) and hypoglycemic agents, some patients do not receive the full advantages of current methods due to several restrictions, such as medication costs, accessibility, and concern about the adverse effects of drugs (Sasani et al, 2021). Due to the potentially severe complications of DM, recognizing new applicable approaches for prevention and controlling DM is critical.

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