Effect of hypoxia on the auditory system of goat fetuses during extrauterine incubation

Nishioka, Nobuko; Nishina, Hiroshige; Yoshida, Koyo; Kinoshita, Katsuyuki; Ehara, Yoshiro

doi:10.1046/j.1341-8076.2002.00080.x

Cited by 5 publications

(2 citation statements)

References 17 publications

(27 reference statements)

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“…It is well known that hearing impairment occurs in the fetuses of pre‐eclamptic mothers . In one study that investigated the effect of hypoxia on the auditory system of goat fetuses during extrauterine incubation, it was found that hypoxia itself influences the auditory system of the fetus . However, the number of studies regarding cochlear function in patients with pre‐eclampsia is limited.…”

Section: Discussionmentioning

confidence: 99%

“…[21][22][23] In one study that investigated the effect of hypoxia on the auditory system of goat fetuses during extrauterine incubation, it was found that hypoxia itself influences the auditory system of the fetus. 24 However, the number of studies regarding cochlear function in patients with preeclampsia is limited. Bakhshaee et al studied cochlear function in 37 patients with pre-eclampsia and 38 control subjects during pregnancy and the postpartum period (within 2 weeks), and they reported hearing impairment in five out of 37 (13.5%) patients during pregnancy.…”

Section: Figurementioning

confidence: 99%

See 1 more Smart Citation

Hearing loss: An unknown complication of pre‐eclampsia?

Terzi¹,

Kale²,

Hasdemir

et al. 2014

J of Obstet and Gynaecol

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Section: Discussionmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Hearing loss: An unknown complication of pre‐eclampsia?

Terzi¹,

Kale²,

Hasdemir

et al. 2014

J of Obstet and Gynaecol

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Gender, nocturnal hypoxia, and arousal influence brainstem auditory evoked potentials in patients with obstructive sleep apnea

Wang

Kong

et al. 2016

Sleep Breath

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Behavioral States of Isolated Goat Fetuses During Extrauterine Incubation

圭子

茂

幸洋

et al. 2010

Juntendo Medical Journal

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IntroductionIn the field of maternal fetal medicine, animal experiments such as the chronic preparation model have been used for many years and provided a substantial amount of knowledge about fetal physiology 1）2） . The chronic preparation model is a wellestablished method of studying fetal physiology and pathology；however, its use means that fetuses cannot be directly affected by researchers, and thus can only be affected indirectly through their mother. Furthermore, responses from the fetus that are not influenced by the mother cannot be Abstract 1．OBJECTIVESTo investigate the physiological states of goat fetuses undergoing extrauterine incubation following isolation from their mother, we analyzed fetal electroencephalograms（EEGs） with power spectral analysis. 2．MATERIALS AND METHODSTen goat fetuses at 124 ± 3.9 days of gestation（term 150 days） were incubated in an artificial womb connected to an extracorporeal membrane oxygenation（ECMO） apparatus. While these fetuses were in a stabilized condition, their EEGs were recorded using a digital data recorder.Electrocortical activity on the EEGs was classified visually as either a high-voltage period or a low-voltage period. The recorded data were then analyzed using a computer. After analogue-todigital conversion at a sampling frequency of 300 Hz with a resolution of 16 bits, power spectral analysis using an auto-regression model was carried out. 3．RESULTSBoth high-voltage and low-voltage periods could be observed on the EEGs of all ten goat fetuses, and these periods appeared to alternate. Power spectral analysis of recorded EEGs in the high-voltage period showed a peak at the 0.5─4 Hz frequency range, which corresponds to the delta band. A peak at the 8─13 Hz frequency range, which corresponds to the alpha band, was observed in the low-voltage period. 4．CONCLUSIONDuring extrauterine incubation, goat fetuses showed two different EEG patterns. This suggests that the fetuses show physiological behavioral states that are independent from those of their mother.

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Effect of hypoxia on the auditory system of goat fetuses during extrauterine incubation

Cited by 5 publications

References 17 publications

Hearing loss: An unknown complication of pre‐eclampsia?

Hearing loss: An unknown complication of pre‐eclampsia?

Gender, nocturnal hypoxia, and arousal influence brainstem auditory evoked potentials in patients with obstructive sleep apnea

Behavioral States of Isolated Goat Fetuses During Extrauterine Incubation

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