Effect of hypocaloric diet-induced weight loss in obese women on plasma apelin and adipose tissue expression of apelin and APJ.

Castan-Laurell, Isabelle; Vítková, Michaela; Daviaud, Danièle; Dray, Cédric; Kováčiková, Michaela; Kováčová, Zuzana; Hejnova, J.; Štich, Vladimír; Valet, Philippe

doi:10.1530/eje-08-0039

Cited by 142 publications

(111 citation statements)

References 14 publications

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“…4 and 5). The notion that apelin signaling is a beneficial physiological response to oxidative stress in adipose is supported by the previous observation that the plasma apelin level is elevated in obesity (25,26). It also explains the previous observations in mice that apelin treatment leads to a significant decrease in plasma lipid hydroperoxide (an index of systemic oxidative stress) (23), and improves glucose uptake in adipose tissue (18).…”

Section: Discussionmentioning

confidence: 58%

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Apelin Attenuates Oxidative Stress in Human Adipocytes

Than

Zhang

Leow

et al. 2014

Journal of Biological Chemistry

101

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Background: Antioxidant effects of apelin on adipocytes are unknown. Results: Apelin not only suppresses production and release of reactive oxygen species, but also relieves oxidative-stress induced cellular dysfunctions in adipocytes. Conclusion: Apelin-APJ signaling acts as the negative autocrine feedbacks against oxidative stress in adipocytes. Significance: Apelin signaling may serve as a potential therapeutic target for metabolic disorders.

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Section: Discussionmentioning

confidence: 58%

“…However, its regulations of oxidative stress in adipocytes have never been investigated. Considering that apelin expression in adipocytes is up-regulated in obesity (17) and its plasma level is increased in obese subjects (25,26), we speculate that apelin may act as the feedback control to limit obesity-associated oxidative stress.…”

mentioning

confidence: 92%

Apelin Attenuates Oxidative Stress in Human Adipocytes

Than

Zhang

Leow

et al. 2014

Journal of Biological Chemistry

101

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“…Changes in apelin levels after weight loss or bariatric surgery in obese individuals were also investigated. Dietinduced weight loss decreases apelin levels in moderate obese women [154] but not significantly in patients with the MetS [155] or in obese children [156] . Bariatric surgery resulted in a significant decrease in apelin levels only in morbidly obese patients exhibiting impaired fasting glucose or type 2 diabetes before surgery [151] .…”

Section: Apelinmentioning

confidence: 90%

Adipose tissue and vascular inflammation in coronary artery disease

Golia¹,

Limongelli²,

Natale³

et al. 2014

WJC

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Obesity has become an important public health issue in Western and developing countries, with well known metabolic and cardiovascular complications. In the last decades, evidence have been growing about the active role of adipose tissue as an endocrine organ in determining these pathological consequences. As a consequence of the expansion of fat depots, in obese subjects, adipose tissue cells develope a phenotypic modification, which turns into a change of the secretory output. Adipocytokines produced by both adipocytes and adipose stromal cells are involved in the modulation of glucose and lipid handling, vascular biology and, moreover, participate to the systemic inflammatory response, which characterizes obesity and metabolic syndrome. This might represent an important pathophysiological link with atherosclerotic complications and cardiovascular events. A great number of adipocytokines have been described recently, linking inflammatory mileu and vascular pathology. The understanding of these pathways is crucial not only from a pathophysiological point of view, but also to a better cardiovascular disease risk stratification and to the identification of possible therapeutic targets. The aim of this paper is to review the role of Adipocytokines as a possible link between obesity and vascular disease. Key words: Adipocytokines; Obesity; Metabolic syndrome; Coronary artery disease; Inflammation Core tip: Our article, provide a comprehensive review of the evidence about adipose tissue and cardiovascular risk, focusing on the pathophysiological and clinical role of fat-derived mediators, the so-called adipocytokines.

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“…Insulin has been shown to be one of the main regulating factors of apelin expression and secretion (Boucher et al 2005). Circulating apelin levels as well as ATexpression increase in obese and hyperinsulinemic subjects (Boucher et al 2005, Castan-Laurell et al 2008. Plasma apelin levels are also raised in morbidly obese (Heinonen et al 2005) and type 2 diabetic (Soriguer et al 2009) subjects.…”

Section: Introductionmentioning

confidence: 99%

“…The high apelin concentrations can be modulated by weight loss. Indeed, it was shown that diet-induced weight loss reduces plasma apelin levels in women with moderate obesity (Castan-Laurell et al 2008), but not significantly in patients with metabolic syndrome (Heinonen et al 2009). Bariatric surgery leads to a significant decrease in plasma apelin in morbidly obese subjects with impaired fasting glucose or type 2 diabetes before surgery (Soriguer et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Apelin stimulates glucose uptake but not lipolysis in human adipose tissue ex vivo

Attané

Daviaud²,

Dray³

et al. 2010

Journal of Molecular Endocrinology

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Apelin is a peptide present in different cell types and secreted by adipocytes in humans and rodents. Apelin exerts its effects through a G-protein-coupled receptor called APJ. During the past years, a role of apelin/APJ in energy metabolism has emerged. Apelin was shown to stimulate glucose uptake in skeletal muscle through an AMP-activated protein kinase (AMPK)-dependent pathway in mice. So far, no metabolic effects of apelin have been reported on human adipose tissue (AT). Thus, the effect of apelin on AMPK in AT was measured as well as AMPK-mediated effects such as inhibition of lipolysis and stimulation of glucose uptake. AMPK and acetyl-CoA carboxylase phosphorylation were measured by western blot to reflect the AMPK activity. Lipolysis and glucose uptake were measured, ex vivo, in response to apelin on isolated adipocytes and explants from AT of the subcutaneous region of healthy subjects (body mass index: 25 . 6 G0 . 8 kg/m 2 , nZ30 in total). APJ mRNA and protein are present in human AT and isolated adipocytes. Apelin stimulated AMPK phosphorylation at Thr-172 in a dose-dependent manner in human AT, which was associated with increased glucose uptake since C compound (20 mM), an AMPK inhibitor, completely prevented apelin-induced glucose uptake. However, in isolated adipocytes or AT explants, apelin had no significant effect on basal and isoprenaline-stimulated lipolysis. Thus, these results reveal, for the first time, that apelin is able to act on human AT in order to stimulate AMPK and glucose uptake.

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Effect of hypocaloric diet-induced weight loss in obese women on plasma apelin and adipose tissue expression of apelin and APJ.

Cited by 142 publications

References 14 publications

Apelin Attenuates Oxidative Stress in Human Adipocytes

Apelin Attenuates Oxidative Stress in Human Adipocytes

Adipose tissue and vascular inflammation in coronary artery disease

Apelin stimulates glucose uptake but not lipolysis in human adipose tissue ex vivo

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