Effect of Hyperbaric Oxygen on Second-Degree Burn Wound Healing

The negative effect of hyperbaric oxygen therapy at the acute phase of electrochemical esophageal burn induced by button battery ingestion

“…Experimental reports, that document the beneficial effects of HBO treatment in the acute phase after the burn injury, indicate: a decrease in the amount of plasma extravasation [18], acceleration and more complete restoration of the capillary permeability [8], preservation of tissue ATP levels in zones adjacent to the burn wound [15], decrease in edema formation and exudation rate in and around (5 mm diameter) partial-thickness burn wound in a human study [5].…”

Periodontal wound healing responses to varying oxygen concentrations and atmospheric pressures

“…Marx (unpublished) also found normobaric 100% oxygen to be effective in enhancing skin wound healing in rabbits. Korn et al (1977) observed improvement in burn wound healing in a hyperbaric 10%…”

“…Although hyperbaric oxygen therapy has primarily been directed toward wound healing, it has also been used to manage carbon monoxide poisoning (Myers et al, 1981) and anaerobic infection (Weinstein and Barza, 1976). Many of the wound healing studies have been involved with the effect of hyperbaric oxygen in the treatment of osteoradionecrosis (Greenwood and Gilchrist, 1973, Mansfield et al, 1981, Marx, 1983, Marx et al, 1985, osteomyelitis (Morrey et al, 1979, Kerley et al, 1981, Triplett et al, 1982 and burns (Korn et al, 1977, Niccole et al, 1977. These studies demonstrated HBO enhancement of fibroblastic activity, angiogenesis and neovascularization in "compromised" tissue, to ultimately promote healing.…”

Hyperbaric Oxygen Therapy of Burns

“…According to Korn, who demonstrated faster epidermization in case of II° burns and capillary patency restoration, the above-mentioned effect could result not only from the oxygen supply but also from its increased pressure (59).…”