Effect of Hydroxymethyl Glutaryl Coenzyme A Reductase Inhibitor Therapy on High Sensitive C-Reactive Protein Levels

Jialal, Ishwarlal; Stein, Daniel T.; Balis, David S.; Grundy, Scott M.; Adams‐Huet, Beverley; Devaraj, Sridevi

doi:10.1161/01.cir.103.15.1933

Cited by 653 publications

(369 citation statements)

References 21 publications

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“…This effect was also seen in other studies and might be independent of LDL cholesterol [89,90]. Several other preventive strategies to lower inflammation and possibly modify cardiovascular risk have been described, such as exercise, blood pressure lowering, weight reduction, smoking cessation, moderate alcohol consumption and improvement of insulin resistance.…”

Section: Lowering Of Inflammatory Markers Might Decrease Cardiovasculsupporting

confidence: 73%

Estrogen, inflammation and cardiovascular risk in women: a critical appraisal

Störk

Schouw

Grobbee

et al. 2004

Trends in Endocrinology & Metabolism

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Section: Lowering Of Inflammatory Markers Might Decrease Cardiovasculsupporting

confidence: 73%

Estrogen, inflammation and cardiovascular risk in women: a critical appraisal

Störk

Schouw

Grobbee

et al. 2004

Trends in Endocrinology & Metabolism

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“…Although the factors directly associated with insulin resistance were not identified as independent deter- minants of CCA-IMT, hs-CRP was identified as an independent determinant of IMT. CRP is decreased by several drugs such as statins and aspirin, alcohol, and life style factors such as exercise and weight loss [12,13,18]. Thus, in this study, to avoid at least the effects of medication on hs-CRP, we chose patients with early type 2 diabetes mellitus who were not on any medication.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with type 2 diabetes mellitus are frequently treated with various types of drugs. Some drugs such as statins, fibrates, aspirin, and thiazolidinediones are known to reduce the serum level of CRP [12][13][14]. The inclusion of patients on these medications might have influenced the results reported in previous studies.…”

mentioning

confidence: 99%

Association of C-reactive Protein with Early-stage Carotid Atherosclerosis in Japanese Patients with Early-state Type 2 Diabetes Mellitus

et al. 2006

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Abstract. The aim of this study was to assess the association between high sensitivity-C-reactive protein (hs-CRP), a sensitive marker of inflammation, and early-stage carotid atherosclerosis, in patients with early-state type 2 diabetes mellitus. The study subjects were 75 patients with type 2 diabetes mellitus without obvious diabetic vascular complications, who were not on any medication, and whose HbA 1c level was less than 6.5%. We evaluated the mean intima-media thickness (IMT) of the common carotid artery (CCA) by ultrasound B-mode imaging. Then, we investigated various factors associated with CCA-IMT including hs-CRP. Serum hs-CRP levels correlated well with factors strongly associated with insulin resistance such as homeostasis model assessment of insulin resistance (HOMA-IR), fasting insulin level, and body mass index. Serum hs-CRP also correlated with mean CCA-IMT and serum levels of soluble intercellular adhesion molecule-1. Multivariate regression analysis using mean CCA-IMT as the dependent variable identified only age, hs-CRP, and diastolic blood pressure as independent determinants of mean CCA-IMT. While hs-CRP associates with insulin resistance and subclinical atherosclerosis in ealy-state type 2 diabetes, our data suggest that hs-CRP is a useful marker of subclinical atherosclerosis in early-state type 2 diabetes mellitus independent of factors that directly reflect insulin resistance.

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“…It is possible that more intensive therapy is required immediately after the onset of ACS during the period of greatest clinical instability to achieve a more rapid clinical benefit. The effects of each statin have been studied on the reduction of hs-CRP levels 37) . Median percent reduction in hs-CRP did not differ significantly among statins; atorvastatin reduced hs-CRP by a median of 28.3%, pravastatin by 20.3%, and simvastatin by 22.8%.…”

Section: Is There Clinical Evidence That Inflammation Can Be Modifiedmentioning

confidence: 99%

An Update on the Role of Markers of Inflammation in Atherosclerosis

Corrado¹,

Rizzo²,

Coppola³

et al. 2010

JAT

172

101

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In recent years, several studies have used the measurement of carotid intima-media thickness (IMT) as a marker of early atherosclerosis: IMT has been shown to correlate significantly with the presence of coronary artery disease (CAD) and to predict fatal and not fatal cerebro-and cardio-vascular events. These findings highlight the importance of recognizing and managing early stages of atherosclerosis for effective cardiovascular prevention. Beyond traditional established cardiovascular risk factors, inflammation has been shown to be crucial throughout atherosclerosis from endothelial dysfunction to plaque rupture and thrombosis. Several studies have shown the existence of a strong relation between CAD and fibrinogen or highly sensitive C-reactive protein (hs-CRP) levels and their predictive role has been examined through stratification or multivariable statistical analyses: levels of these markers of inflammation have been independently associated with the incidence of coronary events after adjusting for traditional cardiovascular risk factors. Recent studies have further addressed the importance of therapeutical modulation of hs-CRP levels in high-risk patients for the prevention of vascular events. The strong relationship between hs-CRP and IMT may potentially account for the complex role of hs-CRP and IMT in the pathogenesis of cardiovascular events. However, beyond the utility of measuring markers of inflammation to assess patients with subclinical carotid atherosclerosis at higher risk of vascular events, further studies are needed to evaluate the therapeutic implications in this category of patients.

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Effect of Hydroxymethyl Glutaryl Coenzyme A Reductase Inhibitor Therapy on High Sensitive C-Reactive Protein Levels

Abstract: Pravastatin, simvastatin, and atorvastatin significantly decreased levels of hs-CRP. These data support an anti-inflammatory effect of these drugs.

Cited by 653 publications

References 21 publications

Estrogen, inflammation and cardiovascular risk in women: a critical appraisal

Estrogen, inflammation and cardiovascular risk in women: a critical appraisal

Association of C-reactive Protein with Early-stage Carotid Atherosclerosis in Japanese Patients with Early-state Type 2 Diabetes Mellitus

An Update on the Role of Markers of Inflammation in Atherosclerosis

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