Effect of hydroxycitrate on food intake and body weight regain after a period of restrictive feeding in male rats

Leonhardt, M.; Hrupka, Brian J.; Langhans, Wolfgang

doi:10.1016/s0031-9384(01)00547-9

Cited by 48 publications

(33 citation statements)

References 15 publications

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“…Previous study had showed that Garcinia Cambogia extracts could enhance energy expenditure in rats . It had reported that the suppressive effect of Garcinia Cambogia extracts on body weight regain cannot only be due to a reduction in food intake, presumably also increased thermogenesis (Leonhardt et al, 2001). Although we did not measure energy expenditure, but an increasing in feed intake provides indirect evidence for that rats supplemental with Garcinia Cambogia extracts were less efficient in using the food energy for the accretion of body mass, which suggests that energy expenditure was increased.…”

Section: Numerous Studies Have Shown An Association Between Garciniamentioning

confidence: 99%

<i>Garcinia Cambogia</i> Extracts Prevented Fat Accumulation via Adiponectin-AMPK Signaling Pathway in Developing Obesity Rats

Liu

Han

et al. 2015

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AbbreviationsACL, ATP-citrate lyase; ACO, Acyl-CoA oxidase; AdipoR1, adiponectin receptor 1; AdipoR2, adiponectin receptor 2; AMPK, adenosine 5'-monophosphate-actvated protein kinase; ATGL, adipose triglyceride lipase; BMI, body mass index; CPT-I, carnitine palmitoyltransferase-I; FAS, fatty acid synthesis; HCA, hydroxycitric acid; HDL, high-density lipoprotein; HL, hepatic lipase; NEFA, nonesterified fatty acid; TC, total cholesterol; TG, triglycerol. Original paper Garcinia Cambogia Extracts Prevented Fat Accumulation via Adiponectin- AMPK Signaling Pathway in Developing Obesity RatsGuanxing Liu, Ningning Han, Jing Han, Di CHen, Jian Kang and Haitian Ma IntroductionObesity is a public health problem which is fast growing throughout the modern world. It is a serious risk factor for so-called lifestyle-related diseases such as diabetes, cardiovascular disease and hypertension (Jebb and Moore, 1999;Nakamura et al., 1994). In addition to exercise, it is well known that anti-obesity foods and food ingredients could control and reduce body weight. Some herbal products and plant extracts, such as Semen Cassiaem (Junbao et al., 2004), Panax ginseng berry extract (Attele et al., 2002), Singiber officinale Roscoe (Hasegawa, 2001), and Platycodi radix (Han et al., 2000) have been shown to exert anti-obesity effects in rodents with high fat diet induced obesity (Kim et al., 2007).Garcinia cambogia is an edible fruit native to Southeast Asia (Saito et al., 2005). Its dried rind has been used for centuries throughout Southeast Asia as a food preservative, flavoring agent and carminative. Also, Garcinia cambogia extracts has been used as an ingredient of dietary supplements for weight loss.(-)-Hydroxycitric acid (HCA), a primary acid and the major active G. Liu et al. 836 ingredient in the fruit rinds of Garcinia Cambogia (Lewis and Neelakantan, 1965), has been shown to suppress appetite, body weight gain and fat accumulation in both experimental animals and humans (Greenwood et al., 1981;Heymsfield et al., 1998;Ohia, 2002;Rao and Sakariah, 1988;Sullivan et al., 1974;. HCA had been identified as a potent competitive inhibitor of the extra-mitochondrial enzyme adenosine triphosphate-citratelyase (Watson and Lowenstein, 1970), which catalyzes the cleavage of citrate in extra-mitochondrial to oxaloacetate and acetyl-CoA, a building block of fatty acids synthesis (Márquez, 2012). The inhibitory action of HCA induces the reduction of acetyl-CoA content, thus limiting the biosynthesis of fatty acids and cholesterol (Lowenstein, 1971;Sullivan et al., 1974). Also, the reduction of acetyl-CoA content could decrease the concentration of malonyl-CoA, which stimulates carnitine palmitoyltransferase I (CPT-1) activity and fatty acid oxidation (Ishihara et al., 2000;McCarty, 1994;Saha et al., 1999). Although some studies had revealed that HCA may suppress de novo fatty acid biosynthesis and appetite (Kovacs and Westerterp-Plantenga, 2006) and increase energy expenditure (Kim et al., 2008), subsequently reducing fat accumulation and b...

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Section: Numerous Studies Have Shown An Association Between Garciniamentioning

confidence: 99%

<i>Garcinia Cambogia</i> Extracts Prevented Fat Accumulation via Adiponectin-AMPK Signaling Pathway in Developing Obesity Rats

Liu

Han

et al. 2015

FSTR

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“…Although no significant interaction was detected, garcinia tended to reduce the food intake under sucrose supplementation. Leonhardt et al (2001) reported on the daily food intake in 3% HCA + high glucose group or high sucrose: food intake in the 3% HCA + high glucose group was significantly lower than in the control (high glucose), whereas the 3% HCA + high sucrose group was not significantly different from the control (high sucrose) statistically. However, 3% HCA + high sucrose tended to reduce food intake depending on the number of administered days.…”

Section: Statistical Methods Data Were Analysed By Two-way Analysis mentioning

confidence: 94%

“…Thus, HCA dose-dependently decreases lipogenesis in the liver, adipose tissue and intestine in vivo (Sullivan et al, 1974b). HCA also reduces food intake and body weight gain (Greenwood et al, 1981;Sullivan et al, 1974a;Sullivan and Triscari, 1977) and reduces body weight regain after body weight loss in rats (Leonhardt et al, 2001).…”

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confidence: 97%

DietaryGarcinia cambogia does not modify skin properties of mice with or without excessive sucrose intake

et al. 2005

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The influence of 3.3% Garcinia cambogia extract on the properties of mouse skin with or without 10% sucrose water loading was investigated. Mice (7-week-old) were given free access to a control diet or a diet containing Garcinia cambogia extract. They were also given water alone or both water and sucrose water. Their skin was compared by both biochemical and histological methods. The collagen and triacylglycerol contents were not significantly different among the four groups. Similarly, electron microscopy revealed no differences in the thickness of the dermis layer or the subcutaneous tissue layer. Mice given the diet containing Garcinia cambogia tended to have a reduced total number of adipocytes, but not significantly. These results suggest that Garcinia cambogia supplementation for at least 4 weeks does not induce a negative effect on skin properties in mice irrespective of excessive sucrose intake.

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“…(−)-HCA or (−)-HCA-containing GA has been shown to suppress body fat accumulation in experimental male rodents [7,[17][18][19][20]. Few data are available for female rodent [21,22].…”

Section: Discussionmentioning

confidence: 99%

Effect of Garcinia cambogia Administration on Female Reproductive Organs in Rats

Kiyose¹,

Kubo²,

Saito³

2006

J. Clin. Biochem. Nutr.

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Summary We investigated the effect of administering Garcinia cambogia (GA), which contains (−)-hydroxycitric acid ((−)-HCA), to female rats, focusing especially on changes in sexual hormones and its safety in terms of histopathological changes. A diet containing a high level of (−)-HCA (154 mmol / kg diet) was given to seven-week-old female rats with matched estrous cycles for two or four weeks. There were no significant differences in any of the serum hormones tested (follicle-stimulating hormone, luteinizing hormone, estradiol and progesterone) between the control group and the GA group during the observation period. Also, there were no abnormal morphological findings in the follicle and corpus luteum, nor were there any significant differences in the ovarian 4,4-dimethyl-5α-cholesta 8,14,24-triene-3β-ol (follicular fluid meiosis-activating sterol; FF-MAS) and 4,4-dimethyl-5α-cholesta-8,24-diene-3β-ol (testis meiosis-activating sterol; T-MAS) concentrations between the control and the GA groups. On the other hand, the final body weight of the GA group was statistically lower than that of the control group. The weight of abdominal fat in the GA group was markedly lower than that in the control group even after two weeks of feeding. Therefore, although we had confirmed in our previous study that GA had a marked effect on sexual maturation in male rats, no such deleterious influence was observed in the female rats.

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Effect of hydroxycitrate on food intake and body weight regain after a period of restrictive feeding in male rats

Cited by 48 publications

References 15 publications

<i>Garcinia Cambogia</i> Extracts Prevented Fat Accumulation via Adiponectin-AMPK Signaling Pathway in Developing Obesity Rats

<i>Garcinia Cambogia</i> Extracts Prevented Fat Accumulation via Adiponectin-AMPK Signaling Pathway in Developing Obesity Rats

DietaryGarcinia cambogia does not modify skin properties of mice with or without excessive sucrose intake

Effect of Garcinia cambogia Administration on Female Reproductive Organs in Rats

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