Effect of hydroxyapatite on the biodegradation and biomechanical stability of polyester nanocomposites for orthopaedic applications

Instructive composites for bone regeneration

“…Similarly to what is reported in literature, higher fluid uptake led to quicker apatite dissolution [249,314] and polymer hydrolysis [349,387] with consequent larger mass loss and ion release. However, increasing amount of apatite accelerated the degradation of the whole composite, which clashes with most of results in literature, [ 235,239,240,242,243,409 ] because in this situation we used an extrusion method, instead of solvent-based ones, to prepare the materials. Extrusion led to decreases in polymer intrinsic viscosity with the increase of apatite content, with direct impact on the composite degradation since the differences of the final intrinsic viscosity amongst the three materials were significantly large (Chapter 4).…”

“…This might be explained with the fact that most of the composites presented in literature were prepared using solvent-based methods (by mixing, casting or sonication/freezing procedures), [239,240,242,243] or co-precipitation. [235,409] It is worth to remind that we have shown in Chapter 3 that solvent-based methods do not degrade the polymer phase, independently from the calcium phosphate phase content. We expect similar results also for other non-thermal methods used for the preparation of composite materials.…”

Preparation and In Vivo Study of Porous Titanium–Polyglycolide Composite

“…A decomposition rate of degradable plastics such as PLA and PGA can be supressed by using high-molecular-weight ones and incorporation of basic materials 10,[24][25][26][27][28]31) . If calcium phosphates or calcium carbonates are employed as the basic materials, the bone ingrowth could be promoted by the calcium release.…”

“…To achieve an effective design for proposed devices, it is important to suppress the initial PGA decomposition. For examples, a crystallinity control of degradable materials by heat treatments or incorporation of basic materials is an effective method for improving the degradation characteristics [24][25][26][27][28] . Recently, an additive manufacturing has been received considerable attentions in several elds, because it has a lot of exibility in the structural design.…”

Biodegradable polymers for dental tissue engineering and regeneration

“…PPF is used as filling for bone defects [198] and as depot for the long-term delivery of ocular drugs [199]. Besides, in osteogenic tissue engineering, PPF is used in association with HA [200] or alumoxane [201] to create bioactive scaffolds. In dentistry, Alge et al produced PPF reinforced dicalcium phosphate dihydrate cement composites to obtain strong materials with mechanical properties suitable for bone tissue engineering.…”