Effect of hydroxyapatite on critical-sized defect

Kim, Ryoe-Woon; Kim, Ji‐Hyoung; Moon, Seong‐Yong

doi:10.1186/s40902-016-0072-2

Cited by 26 publications

(29 citation statements)

References 26 publications

(28 reference statements)

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“…Our results are in agreement with the general assumption that HA has no osteoinductive activity [ 30 , 31 ] and in defects filled with HA alone, healing process largely depends on the osteoconductive properties of the material. Similar results have been reported by many authors [ 32 - 35 ].…”

Section: Discussionsupporting

confidence: 93%

Repair of segmental radial defect with autologous bone marrow aspirate and hydroxyapatite in rabbit radius: A clinical and radiographic evaluation

Yassine¹,

Mokhtar²,

Hemida³

et al. 2017

Vet World

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Aim:Finding an ideal bone substitute to treat large bone defects, delayed union and nonunions remain a challenge for orthopedic surgeons and researchers. Several studies have been conducted on bone regeneration; each has its own advantages and disadvantages. The aim of this study was to evaluate the effect of a combination of hydroxyapatite (HA) powder with autologous bone marrow (BM) aspirate on the repair of segmental radial defect in a rabbit model.Materials and Methods:A total of 36 male and adult New Zealand rabbit with a mean weight of 2.25 kg were used in this study. Approximately, 5 mm defect was created in the mid-shaft of the radius to be filled with HA powder in the control group “HA” (n=18) and with a combination of HA powder and autologous BM aspirate in the test group “HA+BM” (n=18). Animals were observed daily for healing by inspection of the surgical site, and six rabbits of each group were sacrificed at 30, 60, and 90 post-operative days to perform a radiographic evaluation of defect site.Results:Obtained results revealed a better and more rapid bone regeneration in the test group: Since the defect was rapidly and completely filled with mature bone tissue after 90 days.Conclusion:Based on these findings, we could infer that adding a BM aspirate to HA is responsible of a better regeneration process leading to a complete filling of the defect.

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Section: Discussionsupporting

confidence: 93%

Repair of segmental radial defect with autologous bone marrow aspirate and hydroxyapatite in rabbit radius: A clinical and radiographic evaluation

Yassine¹,

Mokhtar²,

Hemida³

et al. 2017

Vet World

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“…The results of this study did not show any statistically significant difference between the 2 groups at 8 and 12 weeks, but unlike the results at 8 weeks, the bone formation ability of Bio-Oss ® showed a slightly increasing tendency compared to Tio-oss ® at 12 weeks. This showed a similar trend with the study results by Kim et al [ 49 ].…”

Section: Discussionsupporting

confidence: 92%

“…Previous studies also reported that synthetic OCP and OCP-based material are highly biodegradable, and these reports showed a similar trend with our results [ 33 , 47 , 48 ]. A study by Kim et al, analyzed the products Bio-Oss ® and Bongros ® (Bio@ Inc., Seongnam, Korea) at 4 and 8 weeks after surgery, and it was observed that Bio-Oss ® (28.5%) showed less bone formation than Bongros ® (42.9%) at 4 weeks, but at 8 weeks, Bio-Oss ® (54.1%) showed more bone formation than Bongros ® (50.9%) [ 49 ]. The results of this study did not show any statistically significant difference between the 2 groups at 8 and 12 weeks, but unlike the results at 8 weeks, the bone formation ability of Bio-Oss ® showed a slightly increasing tendency compared to Tio-oss ® at 12 weeks.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of New Octacalcium Phosphate-Coated Xenograft in Rats Calvarial Defect Model on Bone Regeneration

et al. 2020

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Bone graft material is essential for satisfactory and sufficient bone growth which leads to a successful implant procedure. It is classified into autogenous bone, allobone, xenobone and alloplastic materials. Among them, it has been reported that heterogeneous bone graft material has a porous microstructure that increases blood vessels and bone formation, and shows faster bone formation than other types of bone graft materials. We observed new bone tissue formation and bone remodeling using Ti-oss® (Chiyewon Co., Ltd., Guri, Korea), a heterologous bone graft material. Using a Sprague–Dawley rat calvarial defect model to evaluate the bone healing effect of biomaterials, the efficacy of the newly developed xenograft Ti-oss® and Bio-Oss® (Geistilch Pharma AG, Wolhusen, Switzerland). The experimental animals were sacrificed at 8 and 12 weeks after surgery for each group and the experimental site was extracted. The average new bone area for the Ti-oss® experimental group at 8 weeks was 17.6%. The remaining graft material was 22.7% for the experimental group. The average new bone area for the Ti-oss® group was 24.3% at 12 weeks. The remaining graft material was 22.8% for the experimental group. It can be evaluated that the new bone-forming ability of Ti-oss® with octacalcium phosphate (OCP) has the bone-forming ability corresponding to the conventional products.

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“…The porous structure of HA promotes the ingrowth of cells and microvessel growth leading to bone formation. Moreover, for this bone material, optimal pore sizes from 150 to 500 μm are an important factor in forming new bone [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Enhanced Hydrophilic Titanium Dioxide-Coated Hydroxyapatite on Bone Regeneration in Rabbit Calvarial Defects

Lee

Bark

Quy

et al. 2018

IJMS

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The regeneration of bone defects caused by periodontal disease or trauma is an important goal. Porous hydroxyapatite (HA) is an osteoconductive graft material. However, the hydrophobic properties of HA can be a disadvantage in the initial healing process. HA can be coated with TiO2 to improve its hydrophilicity, and ultraviolet irradiation (UV) can further increase the hydrophilicity by photofunctionalization. This study was designed to evaluate the effect of 5% TiO2-coated HA on rabbit calvarial defects and compare it with that of photofunctionalization on new bone in the early stage. The following four study groups were established, negative control, HA, TiO2-coated HA, and TiO2-coated HA with UV. The animals were sacrificed and the defects were assessed by radiography as well as histologic and histomorphometric analyses. At 2 and 8 weeks postoperatively, the TiO2-coated HA with UV group and TiO2-coated HA group showed significantly higher percentages of new bone than the control group (p < 0.05). UV irradiation increased the extent of new bone formation, and there was a significant difference between the TiO2-coated HA group and TiO2-coated HA with UV group. The combination of TiO2/HA and UV irradiation in bone regeneration appears to induce a favorable response.

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Effect of hydroxyapatite on critical-sized defect

Cited by 26 publications

References 26 publications

Repair of segmental radial defect with autologous bone marrow aspirate and hydroxyapatite in rabbit radius: A clinical and radiographic evaluation

Repair of segmental radial defect with autologous bone marrow aspirate and hydroxyapatite in rabbit radius: A clinical and radiographic evaluation

Evaluation of New Octacalcium Phosphate-Coated Xenograft in Rats Calvarial Defect Model on Bone Regeneration

Effects of Enhanced Hydrophilic Titanium Dioxide-Coated Hydroxyapatite on Bone Regeneration in Rabbit Calvarial Defects

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