Effect of Hydrophilic/Hydrophobic Block Ratio and Temperature on the Surface and Associative Properties of Oxyethylene and Oxybutylene Diblock Copolymers in Aqueous Media

Khan, Abbas; Akil, Hazizan Md; Siddiq, Muhammad

doi:10.1080/01932691.2015.1019625

Cited by 11 publications

(3 citation statements)

References 30 publications

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“…A large number of these applications are concerned with the formation of micelles and hence, micellization of block copolymer has generated substantial interest in the literature [ 7 ]. The interaction along with the aggregation behavior of mixed surfactants in solution and at interfaces has been rigorously investigated using various techniques such as small angle neutron scattering (SANS), dynamic light scattering (DLS), fluorescence, surface tension, viscosity, conductivity, and cyclic voltammeter [ 8 , 9 , 10 , 11 , 12 ]. As Pluronics ® are often employed in complex environments, for instance, in presence of other additives or amphiphile, studies on their effect on solution behavior of copolymers can help to optimize properties based on performance for various applications.…”

Section: Introductionmentioning

confidence: 99%

Dependency of Anion and Chain Length of Imidazolium Based Ionic Liquid on Micellization of the Block Copolymer F127 in Aqueous Solution: An Experimental Deep Insight

et al. 2017

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Abstract:The non-ionic triblock copolymer, Pluronic ® F127, has been selected to observe its interaction with ionic liquids (ILs) in aqueous solutions by using DLS, surface tension, and viscosity measurements. The Critical Micelle Concentration (CMC) of F127 increased with the addition of ILs, which appeared logical since it increases the solubility of PPO (and PEO) moiety, making it behaves more like a hydrophilic block copolymer that is micellized at a higher copolymer concentration. The results from DLS data showed good agreement with those obtained from the surface tension measurements. Upon the addition of ILs, the tendency in micellar size reduction was demonstrated by viscosity results, and therefore, intrinsic viscosity decreased compared to pure F127 in aqueous solution. The results were discussed as a function of alkyl chain length and anions of imidazolium based ILs.

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Section: Introductionmentioning

confidence: 99%

Dependency of Anion and Chain Length of Imidazolium Based Ionic Liquid on Micellization of the Block Copolymer F127 in Aqueous Solution: An Experimental Deep Insight

et al. 2017

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“…Nonionic EO–BO–EO triblock copolymers act as smart surfactants because of their tremendous surface-active properties. ,, Various literature studies have paid particular attention to the cmc of EO–BO–EO triblock copolymers using S.T. (γ) measurements. ,− The S.T. curves presented in Figure showed typical behavior of BCPs, where an increase in the amount of polymer in aqueous solution leads to a sharp decrease in γ up to a specific concentration called as cmc, and beyond that, no prominent decrease in γ is observed.…”

Section: Resultsmentioning

confidence: 99%

“…This enables the micellization at much lower copolymer concentrations which make them act as excellent drug delivery nanocarriers. Several groups have illustrated the solution behavior and self-associative properties of varied EO–BO–EO-based BCPs in aqueous medium using various fundamental physicochemical techniques, while a few studies have reported the mixed micellization of these copolymers. ,− In addition, the gelation and rheological behavior of these copolymers have also been reported for the drug solubilization and transport study as effective nanocarrier reservoirs for the sustained drug delivery for oral and topical administration. − …”

Section: Introductionmentioning

confidence: 99%

Self-Association in EO–BO–EO Triblock Copolymers as a Nanocarrier Template for Sustainable Release of Anticancer Drugs

et al. 2020

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Ethylene oxide (EO)−butylene oxide (BO)−ethylene oxide (EO)-based triblock copolymers with varying hydrophilic−hydrophobic ratios in arrangement, generally referred to as EBE, were scrutinized in an aqueous environment. Various selfassociative (micellization) physicochemical properties of these EBEs were examined at different temperatures unified with a quantum chemical study. The salting-out effect on 5%w/v EBE was examined by observing their aqueous solution behavior where the clear transparent solution/turbidity suggested the probable presence of spherical or ellipsoidal micelles, which was confirmed from the scattering outline. The hydrodynamic radius (D h ) of the formed micellar geometry as a function of temperature and electrolyte (2 M NaCl) was inspected from dynamic light scattering and further supported by small-angle neutron scattering, where the Q-range prototype and scattering parameters were evaluated by the best fitting of the structure factor. Furthermore, these micelles were employed as potential nanocarriers for anticancer (curcumin and quercetin) drugs, where its release profile at a particular time interval was estimated using UV−vis spectroscopy. Different kinetic models were employed to fit the release profile data that enabled this study to act as an ideal platform for drug delivery. Also, the plausible interactions between EO−BO−EO blocks and the anticancer drugs were inferred from the evaluated computational descriptors.

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Functional properties of chitosan built nanohydrogel with enhanced glucose-sensitivity

Othman

Javed

Ahmad

et al. 2016

International Journal of Biological Macromolecules

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Effect of Hydrophilic/Hydrophobic Block Ratio and Temperature on the Surface and Associative Properties of Oxyethylene and Oxybutylene Diblock Copolymers in Aqueous Media

Cited by 11 publications

References 30 publications

Dependency of Anion and Chain Length of Imidazolium Based Ionic Liquid on Micellization of the Block Copolymer F127 in Aqueous Solution: An Experimental Deep Insight

Dependency of Anion and Chain Length of Imidazolium Based Ionic Liquid on Micellization of the Block Copolymer F127 in Aqueous Solution: An Experimental Deep Insight

Self-Association in EO–BO–EO Triblock Copolymers as a Nanocarrier Template for Sustainable Release of Anticancer Drugs

Functional properties of chitosan built nanohydrogel with enhanced glucose-sensitivity

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