Functional properties of chitosan built nanohydrogel with enhanced glucose-sensitivity

Othman, Muhammad Bisyrul Hafi; Javed, Fatima; Ahmad, Zulkifli; Akil, Hazizan Md; Rasib, Siti Zalifah Md

doi:10.1016/j.ijbiomac.2015.11.040

Cited by 19 publications

(7 citation statements)

References 27 publications

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“…Reduction in swelling can lead to decreased availability of water for drug dissolution or dispersion, resulting in faster drug release. 55 3.5. Release Profile of Catechin from GM Microneedles.…”

Section: Ftir Analysis Of Microneedlementioning

confidence: 99%

Effect of Microsphere Concentration on Catechin Release from Microneedle Arrays

Sabbagh,

Deshmukh,

Choi

et al. 2024

ACS Appl. Mater. Interfaces

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In this work, microspheres were developed by crosslinking glutaraldehyde in an aqueous gelatin solution with a surfactant and solvent. A poly(vinyl alcohol) (PVA) solution was produced and combined with catechin-loaded microspheres. Different microsphere concentrations (0%, 5%, 10%, and 15%) were applied to the PVA microneedles. The moisture content, particle size, swelling, and drug release percentage of microneedles were studied using various microsphere concentrations. Fourier transform infrared and scanning electron microscopy (SEM) investigations validated the structure of gelatin microspheres as well as their decoration in microneedles. The SEM scans revealed that spherical microspheres with a wrinkled and folded morphology were created, with no physical holes visible on the surface. The gelatin microspheres generated had a mean particle size of 20−30 μm. Ex vivo release analysis indicated that microneedles containing 10% microspheres released the most catechin, with 42.9% at 12 h and 84.4% at 24 h.

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Section: Ftir Analysis Of Microneedlementioning

confidence: 99%

Effect of Microsphere Concentration on Catechin Release from Microneedle Arrays

Sabbagh,

Deshmukh,

Choi

et al. 2024

ACS Appl. Mater. Interfaces

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“…These materials, which exploited the exceptional performance of the PBA glucose-responsive system, displayed advanced features, such as high insulin loading capacity, function under physiological conditions, satisfactory glucose adsorption, and controlled-rate release of insulin, among others. [113][114][115][116] Similarly, the preference of borate ions to form a complex with glucose was exploited to produce films based on CS and PVA that disintegrated by a glucose-triggered mechanism to release anticancer drugs. 117,118 Interestingly, Li et al exploited the benefits of a double-crosslinked dynamic network hydrogel, with enhanced mechanical properties (G' = 5.7 kPa) and mucoadhesive ability, to deliver the antitumor drug DOX.…”

Section: Responsive Delivery Applicationsmentioning

confidence: 99%

“…More recently, several CS-based hydrogels that make use of the dynamic boronate ester bond have been prepared, tested, and used as carriers for glucose-responsive insulin release. These materials, which exploited the exceptional performance of the PBA glucose-responsive system, displayed advanced features, such as high insulin loading capacity, function under physiological conditions, satisfactory glucose adsorption, and controlled-rate release of insulin, among others. − Similarly, the preference of borate ions to form a complex with glucose was exploited to produce films based on CS and PVA that disintegrated by a glucose-triggered mechanism to release anticancer drugs. , …”

Section: Focus On Chitosan-based Hydrogelsmentioning

confidence: 99%

Advanced Functional Hydrogel Biomaterials Based on Dynamic B–O Bonds and Polysaccharide Building Blocks

et al. 2020

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Dynamic covalent chemistry applied to polymers has attracted significant attention over the past decade. Within this area, this review highlights the recent research on polysaccharide-based hydrogels cross-linked by boronic-acid moieties, illustrating its versatility and relevance in biomaterials science to design self-healing, multiple stimuli-responsive, and adaptive biointerfaces and advanced functional devices. strategies and synthetic routes, compatibility with biological tissues, mechanical strength, high permeability to various solutes and high ionic conductivity) but, in addition, exhibit superior performance and cutting-edge properties. In particular, properties such as self-healing, 7 multiple stimuli-responsiveness, 8 and adaptive macroscale properties (shape-memory, stretchability, and reprocessability), [9][10][11] enable their use for real-world applications. 12 As the structure of physically cross-linked hydrogels is unstable under small environmental changes and present limited robustness, while the irreversible nature of chemical cross-links prevents their use in shear-thinning and self-healing applications, hydrogels based on dynamic covalent interactions have emerged as an attractive alternative to reach such high-value features. 13 Indeed, in comparison with non-covalent bonds (i.e. hydrogen bonds, 14,15 van der Waals interactions, 16 π-π stacking, 17 metal-ligand coordination, 18,19 electrostatic interactions, 20 or host-guest interactions 21 ), dynamic covalent chemistry exhibits higher stability and affords reversibility under specific conditions or stimuli. 22 The range of dynamic covalent chemistry that has been exploited to produce healable polymers includes nucleophilic substitutions, imine chemistry, Diels-Alder reactions, disulfide exchange chemistry, thiol-Michael exchange, transthioesterifications, boronic esters and boronates, Si-O exchange in siloxanes and silyl ethers, among others. 23 Briefly, the dynamic bond is a class of bond that can selectively, reversibly break and reform, under equilibrium conditions, without irreversible side reactions. 24 Dynamic covalent networks are influenced by external factors (such as temperature, water content, concentration, or the presence of Lewis bases, among others) and their components easily assemble and disassemble according to physicochemical cues. Due to their nature, dynamic bonds permit stress relaxation, material flow and higher stability, thus combining the advantages of both physically and

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“…The glucose-sensitive nanogels with improved biocompatibility and degradability have attracted more interest. A novel multifunctional chitosan and PBA-based nanohydrogel with enhanced glucose sensitivity was designed, which was prepared by the modification of chitosan-poly (acrylamide- co -methacrylic acid) nanohydrogel with 3-APBA [80]. The glucose-triggered volume phase transition and release profile of the model drug ARS (comparative to insulin as a drug as well as a dye for bioseparation) were studied at various glucose concentrations, pH, and ionic strengths.…”

Section: Pba-functionalized Nanogelsmentioning

confidence: 99%

Recent Advances in Phenylboronic Acid-Based Gels with Potential for Self-Regulated Drug Delivery

et al. 2019

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Glucose-sensitive drug platforms are highly attractive in the field of self-regulated drug delivery. Drug carriers based on boronic acid (BA), especially phenylboronic acid (PBA), have been designed for glucose-sensitive self-regulated insulin delivery. The PBA-functionalized gels have attracted more interest in recent years. The cross-linked three-dimensional (3D) structure endows the glucose-sensitive gels with great physicochemical properties. The PBA-based platforms with cross-linked structures have found promising applications in self-regulated drug delivery systems. This article summarizes some recent attempts at the developments of PBA-mediated glucose-sensitive gels for self-regulated drug delivery. The PBA-based glucose-sensitive gels, including hydrogels, microgels, and nanogels, are expected to significantly promote the development of smart self-regulated drug delivery systems for diabetes therapy.

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Functional properties of chitosan built nanohydrogel with enhanced glucose-sensitivity

Cited by 19 publications

References 27 publications

Effect of Microsphere Concentration on Catechin Release from Microneedle Arrays

Effect of Microsphere Concentration on Catechin Release from Microneedle Arrays

Advanced Functional Hydrogel Biomaterials Based on Dynamic B–O Bonds and Polysaccharide Building Blocks

Recent Advances in Phenylboronic Acid-Based Gels with Potential for Self-Regulated Drug Delivery

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