Effect of hydrophilic coating on microorganism colonization in silicone tubing

Çağavi, Ferda; Akalan, Nejat; Çelik, H. Hamdi; Gür, Deniz; Güçiz, B.

doi:10.1007/s00701-004-0262-z

Cited by 37 publications

(35 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Bacteria adhering to outer surfaces of the shunt catheters can be cleared by the cellular immune system, but the inner surface is isolated from the immune system and provides an environment for bacterial colonization, eventually leading to shunt failure (Bayston et al 2004(Bayston et al , 2005. Antibiotic treatment of the shunt infections often fails (Furno et al 2004;Livni et al 2004), so attempts have been made to prevent bacteria adhesion and colonization by modifying the shunt material (Kohnen et al 2003;Cagavi et al 2004;Bayston et al 2005;Liang et al 2006).…”

Section: Biological Responses To Silicone Shuntsmentioning

confidence: 99%

“…Surface modification with hydrophilic polymer coatings has been used to reduce bacterial adhesion. The rationale for this approach is that hydrophilic surfaces reduce bacterial adhesion, and hydrated hydrophilic polymers have fewer adhesion-promoting surface irregularities (Cagavi et al 2004;Bayston et al 2005). The results demonstrate that hydrophilic coating can reduce bacterial adhesion but not colonization (Cagavi et al 2004).…”

Section: Biological Responses To Silicone Shuntsmentioning

confidence: 99%

See 1 more Smart Citation

Biomaterials for the central nervous system

Zhong

Bellamkonda

2008

J. R. Soc. Interface.

215

163

View full text Add to dashboard Cite

Biomaterials are widely used to help treat neurological disorders and/or improve functional recovery in the central nervous system (CNS). This article reviews the application of biomaterials in (i) shunting systems for hydrocephalus, (ii) cortical neural prosthetics, (iii) drug delivery in the CNS, (iv) hydrogel scaffolds for CNS repair, and (v) neural stem cell encapsulation for neurotrauma. The biological and material requirements for the biomaterials in these applications are discussed. The difficulties that the biomaterials might face in each application and the possible solutions are also reviewed in this article.

show abstract

Section: Biological Responses To Silicone Shuntsmentioning

confidence: 99%

Section: Biological Responses To Silicone Shuntsmentioning

confidence: 99%

Biomaterials for the central nervous system

Zhong

Bellamkonda

2008

J. R. Soc. Interface.

215

163

View full text Add to dashboard Cite

show abstract

“…The biofilm on biomaterial surfaces is usually resistant to antibiotic killing and infection can often only be eradicated by the removal of the infected biomaterial. Therefore, several strategies have been developed to control the biofilm related to implant-associated infections, such as i) by using non-protein adsorptive surfaces [53,54], ii) pre-colonization of surfaces with non-pathogenic bacteria for nich masking [55], iii) coating of antibiotics [53,56,57], and iv) surfaces containing biocidal substances [58,59]. Providing the advantages of the stability in vivo of AMP and lack of resistance development, pre-coating biomaterial surfaces with antimicrobial agents including HBD-3 of Vn would be an effective effort to prevent biofilm formation, and would in the long run reduce survival of microorganisms.…”

Section: Vitronectin and Future Therapeutic Applicationsmentioning

confidence: 99%

Vitronectin in host pathogen interactions and antimicrobial therapeutic applications

Singh

Riesbeck

2011

Open Life Sciences

View full text Add to dashboard Cite

Vitronectin (Vn) is a multifunctional glycoprotein profusely present in serum and bound to epithelial cell surfaces. It plays an important role in cell migration, tissue repair and regulation of membrane attack complex (MAC) formation. In the last decade the role of Vn has been extensively investigated in eukaryotic signalling and cell migration leading to the possibility of developing novel anticancer drugs. In parallel, several studies have suggested that pathogens utilize Vn in invasion of the host. Here we review the properties of Vn and its role in host-pathogen interactions that might be a future target for therapeutic intervention.

show abstract

“…Catheter and agar medium were mixed in the vortex mixer and placed on petri dishes. After their solidification, the petri dishes were incubated at 37°C for 24 h. This procedure was applied to each catheter piece separately for all groups [7]. …”

Section: Methodsmentioning

confidence: 99%

“…Antimicrobial efficacy was evaluated by counting the number of colonies [7], and by measuring the diameter of the inhibition zone [8]. …”

Section: Methodsmentioning

confidence: 99%

Comparison of the Efficacies of Antibiotic-Impregnated and Silver-Impregnated Ventricular Catheters on the Prevention of Infections

Seçer¹,

Kural²,

Kaplan³

et al. 2008

Pediatr Neurosurg

View full text Add to dashboard Cite

Background and Objective: Infection of the cerebrospinal fluid is a life-threatening condition which is usually treated with systemic antibiotics and continued ventricular drainage in children. The aim of this study was to analyze the antimicrobial activities of two antimicrobial-agent-impregnated ventricular catheters and to compare their efficacies on the bacterial cultures. Methods: Antibiotic-impregnated (clindamycin and rifampicin), silver-impregnated, and standard ventricular catheters were used in this study. The experiment was performed in 2 steps. In the first step, small pieces of the catheters were cut and incubated. Then, they were washed and placed in agar medium. Finally, the number of colonies was counted. In the second step, the pieces of catheters were placed on agar plates containing Staphylococcus aureus,Staphylococcus epidermidis, and Pseudomonas aeruginosa. The plates were incubated, and then, the inhibition zone for each catheter was measured. Results: An inhibition zone was observed only in the plates for antibiotic-impregnated catheters. In the other plates, no inhibition zone was detected. The number of colonies was lowest in the plate with the silver-impregnated catheter, followed by the antibiotic-impregnated and standard catheters. Conclusion: The antibiotic-impregnated catheter seems more effective for antimicrobial treatment. Although no inhibition zone was found in the plates for silver-impregnated catheters, these catheters allow the lowest bacterial colonization in agar.

show abstract

Effect of hydrophilic coating on microorganism colonization in silicone tubing

Abstract: Coated material catheters are superior to silicone catheters and they prevent bacterial colonization in some respect.

Cited by 37 publications

References 13 publications

Biomaterials for the central nervous system

Biomaterials for the central nervous system

Vitronectin in host pathogen interactions and antimicrobial therapeutic applications

Comparison of the Efficacies of Antibiotic-Impregnated and Silver-Impregnated Ventricular Catheters on the Prevention of Infections

Contact Info

Product

Resources

About