Effect of Humidity on the Physical Properties of Aspirin Tablets Produced By Melt Granulation and Slugging Methods

Avbunudiogba, John A.

doi:10.9790/3008-0752025

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…Compressed tablet of different formulation were stored at room temperature in airtight amber colour container for future study [6][7][8][9][10][11].…”

Section: Concentrationmentioning

confidence: 99%

Synthesis, Purification, Identification of Aspirin and Evaluation on the Basis of Drug Release with Different Aspirin Formulation

Chakraborty¹

2022

IJRASET

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Aspirin is 2-acetoxy benzoic acid. It is one of the derivatives of Benzoic acid. It is white crystalline fine powder. Aspirin is acetylated product. This drug is under non-steroidal anti-inflammatory drug in which they block cyclooxygenase receptor by inhibiting COX pathway. The drug can block the production of prostaglandin derivative. Therefore they can be used as an analgesic cum antiinflammatory.

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“…Compressed tablet of different formulation were stored at room temperature in airtight amber colour container for future study [6][7][8][9][10][11].…”

Section: Concentrationmentioning

confidence: 99%

Synthesis, Purification, Identification of Aspirin and Evaluation on the Basis of Drug Release with Different Aspirin Formulation

Chakraborty¹

2022

IJRASET

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“…Its hypoallergenic and emollient properties make it the ingredient of choice in many pharmaceutical and cosmetic formulations where it is used as a thickener. Carnauba wax-based lipophilic matrix tablet has been designed recently to protect drugs such as acetyl salicylic acid from hydrolytic degradation during production [1]. Other goals of preparation include, improved/controlled drug release, reduction of ortho oxidation and possible reduction in the cost of production [2,3].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Evaluation of Matrix Tablet of Metronidazole Using Carnauba Wax

Arhewoh

Eraga

Avbunudiogba

et al. 2015

BJPR

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Aim: To formulate a sustained release tablet dosage form of metronidazole using carnauba wax as matrix former and binder. Methods: Batches of metronidazole tablets were formulated by using a combination of melt and wet granulation techniques. The formulated granules were evaluated for their flow properties, while the tablets for their friability, hardness, disintegration time and metronidazole release rate. The effect of varying concentrations of carnauba wax on the formulation was ascertained and compared with a conventional commercial product. Results: The tablets had friability and hardness values ranging from 0.87-2.98% and 6.66 to 8.08 kp, respectively. Tablet weights did not vary significantly but the disintegration time varied from 2.61 to 4.86 min and the optimal batch of tablets released about 60% of its drug within 2 h as against that of the conventional tablet with a 100% release. Original Research ArticleConclusion: Carnauba wax can serve as a suitable binder to formulate a sustained release metronidazole tablets to achieve a reduction in the frequency of administration and consequently enhance compliance.

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“…Many carnauba wax-based lipophilic matrix tablets have been successfully designed to protect drugs from hydrolytic degradation (Avbunudiogba et al, 2013) and control or sustain drug release (Ahmed and Khalil, 2014;Arhewoh et al, 2015;Onyechi and Okafo, 2016).…”

mentioning

confidence: 99%

Modulatory effect of high molecular weight polyethylene glycols on drug release from ibuprofen matrix tablets

Eraga¹,

Eboh²,

Iwuagwu³

2017

Journal of Applied Sciences and Environmental Management

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ABSTRACT:The work aim at investigating the channeling or modulatory effects of polyethylene glycol (PEG) (MW 4000 and 6000) on drug release from ibuprofen sustained release formulation. Different batches of ibuprofen matrix granules and tablet were prepared by melt granulation using different concentrations of carnauba wax and PEG at different ratios. The granule flow properties and various tablets parameters were evaluated using standard procedures. Drug release kinetics and mechanisms from the tablets were investigated as well as DSC and FTIR drug-excipients compatibility. The granules showed increasingly close packing with increase in the amounts of PEG incorporated. All the tablets did not meet compendial specifications with regard to crushing strength and friability. The release rate and extent of release were found to be influenced by the amount of PEG used as well as the carnauba wax concentration. PEG combination of equal amounts produced the highest release of 91 % in the formulation prepared with 12.20 %w/w of carnauba wax while a 1:2 combination in tablets prepared with 24.40 %w/w of carnauba wax gave a maximum drug release of 83 %. Drug release kinetic and mechanism were most consistent with the Higuchi model hence the release was diffusion mediated. DSC and FTIR studies showed no interactions between ibuprofen and the excipients. Carnauba wax-PEG system can be used successfully as a matrix former to sustain the release of ibuprofen for over 6 h. The studies indicate that the proper balance between a matrix former and a channeling agent can produce a desired drug dissolution profile. © JASEM https://dx.doi.org/10.4314/jasem.v21i5.9

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Effect of Humidity on the Physical Properties of Aspirin Tablets Produced By Melt Granulation and Slugging Methods

Cited by 3 publications

References 9 publications

Synthesis, Purification, Identification of Aspirin and Evaluation on the Basis of Drug Release with Different Aspirin Formulation

Synthesis, Purification, Identification of Aspirin and Evaluation on the Basis of Drug Release with Different Aspirin Formulation

Preparation and Evaluation of Matrix Tablet of Metronidazole Using Carnauba Wax

Modulatory effect of high molecular weight polyethylene glycols on drug release from ibuprofen matrix tablets

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