Effect of human trabecular bone composition on its electrical properties

Sierpowska, Joanna; Lammi, Mikko J.; Hakulinen, Mikko; Jurvelin, Jukka S.; Lappalainen, Reijo; Töyräs, Juha

doi:10.1016/j.medengphy.2006.09.007

Cited by 48 publications

(52 citation statements)

References 32 publications

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“…Notably, two CGCaP variants that span the physiological range of CaP wt% in bone (33–71 wt%) (Bloebaum et al, 1997; Pietrzak and Woodell-May, 2005; Sierpowska et al, 2007; Yeni et al, 1998) were validated (40 and 80 wt%) Gleeson et al, 2010. These results were in good agreement with predictions made via previously described concurrent mapping approach (Harley et al, 2010a; Lynn et al, 2010) to predict CaP wt% as a function of suspension phosphoric acid and calcium salts content.…”

Section: Discussionsupporting

confidence: 81%

The impact of discrete compartments of a multi-compartment collagen–GAG scaffold on overall construct biophysical properties

Weisgerber

Kelkhoff

Caliari

et al. 2013

Journal of the Mechanical Behavior of Biomedical Materials

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Orthopedic interfaces such as the tendon-bone junction (TBJ) present unique challenges for biomaterials development. Here we describe a multi-compartment collagen–GAG scaffold fabricated via lyophilization that contains discrete mineralized (CGCaP) and non-mineralized (CG) regions joined by a continuous interface. Modifying CGCaP preparation approaches, we demonstrated scaffold variants of increasing mineral content (40 vs. 80 wt% CaP). We report the impact of fabrication parameters on microstructure, composition, elastic modulus, and permeability of the entire multi-compartment scaffold as well as discrete mineralized and non-mineralized compartments. Notably, individual mineralized and non-mineralized compartments differentially impacted the global properties of the multi-compartment composite. Of particular interest for the development of mechanically-loaded multi-compartment composites, the elastic modulus and permeability of the entire construct were governed primarily by the non-mineralized and mineralized compartments, respectively. Based on these results we hypothesize spatial variations in scaffold structural, compositional, and mechanical properties may be an important design parameter in orthopedic interface repair.

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Section: Discussionsupporting

confidence: 81%

The impact of discrete compartments of a multi-compartment collagen–GAG scaffold on overall construct biophysical properties

Weisgerber

Kelkhoff

Caliari

et al. 2013

Journal of the Mechanical Behavior of Biomedical Materials

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“…Therefore, it is expected that detection of the properties related to interstitial water by the electrical impedance method provides a useful parameter for predicting extracellular matrix structure and mechanical properties of degenerated cartilage or repaired cartilage. However, the relationship between electrical impedance and mechanical property has not been clarified in previous studies [13,14,[18][19][20]. The purpose of the present study was to investigate the effectiveness of the electrical impedance method in terms of quantitatively measuring mechanical properties of articular cartilage.…”

Section: Introductionmentioning

confidence: 95%

“…Sierpowska et al [14] showed the specific impedance of human trabecular bone was strongly related to its dry density and water content. Therefore, the electrical impedance method provides some parameters for understanding the internal structure and physiological functions of biological tissue.…”

Section: Introductionmentioning

confidence: 99%

A feasibility study for evaluation of mechanical properties of articular cartilage with a two-electrode electrical impedance method

Morita

Kondo

Tomita

et al. 2012

Journal of Orthopaedic Science

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“…During the last years, electrical impedance has shown to be a nondestructive, low-invasive and useful instrumental technique to characterize biological tissues [Valentinuzzi et al, 1996;Sierpowska et al, 2007]. Information about electrical characteristics of the tissues under examination is collected by delivering low-level sinusoidal currents, at a given frequency (or frequencies), by external electrodes, such as in electrical impedance spectroscopy (EIS) [Barsoukov et al, 2005].…”

Section: Introductionmentioning

confidence: 99%

Monitoring of Fixture Osteointegration after BAHA® Implantation

Clemente¹,

Costa²,

Monini³

et al. 2010

Audiol Neurotol

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The osteointegration phase of BAHA® fixture was assessed via electrical impedance spectroscopy in BAHA® implantees. Measurements were carried out by using a prototype device and were correlated with previously published histological data obtained at certain times after surgery, i.e. 1–2 days, 1 week, 1 and 3 months. Module variations of impedance spectra were found to be in agreement with the different pathophysiological conditions of bone ingrowth. The proposed methodology has shown to be promisingly reliable to properly monitor BAHA fixture osteointegration.

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Effect of human trabecular bone composition on its electrical properties

Cited by 48 publications

References 32 publications

The impact of discrete compartments of a multi-compartment collagen–GAG scaffold on overall construct biophysical properties

The impact of discrete compartments of a multi-compartment collagen–GAG scaffold on overall construct biophysical properties

A feasibility study for evaluation of mechanical properties of articular cartilage with a two-electrode electrical impedance method

Monitoring of Fixture Osteointegration after BAHA® Implantation

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