A feasibility study for evaluation of mechanical properties of articular cartilage with a two-electrode electrical impedance method

Morita, Yusuke; Kondo, Hideo; Tomita, Naohide; Suzuki, Shigehiko

doi:10.1007/s00776-012-0208-x

Cited by 4 publications

(4 citation statements)

References 21 publications

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“…Cartilage degeneration can be evaluated by capitalizing on its bioelectrical properties. Streaming potential due to positively-charged sodium ions and negatively-charged GAGs 25 , 26 or bulk electrical impedance due to water content 108 can be used to assess the integrity of cartilage, which can be graded with both noninvasive external methods and in vivo methods. By loading and unloading the knee, fluid flow generates a flux of sodium ions, which creates a streaming potential that can be measured both noninvasively and in vivo .…”

Section: Bioelectricitymentioning

confidence: 99%

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High-Resolution Methods for Diagnosing Cartilage Damage In Vivo

et al. 2015

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Advances in current clinical modalities, including magnetic resonance imaging and computed tomography, allow for earlier diagnoses of cartilage damage that could mitigate progression to osteoarthritis. However, current imaging modalities do not detect submicrometer damage. Developments in in vivo or arthroscopic techniques, including optical coherence tomography, ultrasonography, bioelectricity including streaming potential measurement, noninvasive electroarthrography, and multiphoton microscopy can detect damage at an earlier time point, but they are limited by a lack of penetration and the ability to assess an entire joint. This article reviews current advancements in clinical and developing modalities that can aid in the early diagnosis of cartilage injury and facilitate studies of interventional therapeutics.

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Section: Bioelectricitymentioning

confidence: 99%

“…The electrical resistivity significantly decreases after hyaluronidase or collagenase treatment, and the amplitude of change is dependent on the duration of treatment with enzymes. 108 This concept has potential to be used in a clinical setting to diagnose altered matrix integrity.…”

Section: Bioelectricitymentioning

confidence: 99%

High-Resolution Methods for Diagnosing Cartilage Damage In Vivo

et al. 2015

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“…[13] took into account volunteers with healthy and pathological knees, using tetrapolar electrodes introducing currents of 2mA at 20 kHz; the results obtained were important, so they concluded that plethysmography, as a non-invasive method, could be used to diagnose osteoarthritis of the knee [12], [13]. This technique quantitatively measured the mechanical properties of articular cartilage in an animal model treated with enzymes determining the correlation between mechanical and electrical properties [14]. Electrical impedance tomography (EIT) systems are characterized by their ability to estimate the internal structural conductivity distribution of any object by means of the application of alternating currents with frequencies usually higher than 50 kHz, measuring the potentials generated by means of electrodes located on the object boundary and after that, using image reconstruction algorithms, it is possible to estimate the impedance distribution of the studied object [49], [50].…”

Section: Bioimpedancementioning

confidence: 99%

Tomography for electrical impedance

Sánchez¹,

Leyton²

2020

ing. Solidar

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Introduction:This review article shows the state of the art of different techniques for monitoring joint injuries. This work is the product of the research project "Viability of electrical impedance tomography for the monitoring of joint injuries", which took place at the University of Cauca during the period 2018-2019. Aim:Identify non-invasive bio-image methods that are used in the evaluation of joint diseases. Methodology: Selection and review of papers related to the evaluation of joint injuries using non-invasive bio-image technologies using systematic mapping. Results: Magnetic resonance and computed tomography systems make up the non-invasive methods of greater reliability and application in the evaluation of joint injuries. Similarly, some studies show good results from other methods such as systems based on bio-impedance when monitoring the deterioration of joint cartilage. However, electrical impedance tomography (EIT) devices have not yet been widely studied in the joint injuries evaluation. Conclusion: Electronic prototypes of low-cost electrical impedance tomography have been developed that have allowed for the detection and recognition of gestures made by hand from the analysis of the distribution of conductivity in the wrist joint, which allows us to infer that EIT could be a good alternative for the monitoring of joint injuries. Originality: The literature does not show studies focused on the development and implementation of EIT systems in medical applications related to joint injuries. Limitations: This review paper only mentions those studies that describe the non-invasive bio-image methods used to evaluate joint diseases, including the medical applications of EIT systems.

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“…1) The contents of sulfated glycosaminoglycan (sGAG) which is the major component of aggrecan and type II collagen in cartilage disks were determined as previously reported. 1) A custom-made compliance-testing apparatus 11,12) was used to determine the mechanical property of cartilage disk. A cartilage disk was submerged in saline solution placed in a stainless steel plate during the test.…”

mentioning

confidence: 99%