Effect of human lysozyme (muramidase) on potassium handling by the perfused rat kidney. A mechanism for renal damage in human monocytic leukaemia.

Mason, D Y; Howes, D.; Taylor, C R; Ross, B. D.

doi:10.1136/jcp.28.9.722

Cited by 17 publications

(5 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…40 The mechanism of hypokalemia is due to inappropriate kaliuresis and has been postulated to be secondary to increased serum lysozyme levels and lysozymuria-induced tubular damage. 41 The frequency of hypokalemia is so high that patients with acute myelogenous leukemia should have frequent laboratory monitoring and electrolyte supplementation as needed.…”

Section: Hypokalemia Associated With Cancermentioning

confidence: 99%

Electrolyte Disorders Associated With Cancer

Rosner

Dalkin

2014

Advances in Chronic Kidney Disease

101

View full text Add to dashboard Cite

Section: Hypokalemia Associated With Cancermentioning

confidence: 99%

Electrolyte Disorders Associated With Cancer

Rosner

Dalkin

2014

Advances in Chronic Kidney Disease

101

View full text Add to dashboard Cite

“…wt. 13 0oO; Mason, Howes, Taylor & Ross, 1975). An additional feature of the histological distribution of light chain was the diffuse staining observed in distal tubular cells.…”

Section: Renal Handling Of Human Light Chainmentioning

confidence: 82%

Characteristics of Renal Handling of Human Immunoglobulin Light Chain by the Perfused Rat Kidney

et al. 1979

View full text Add to dashboard Cite

1. The renal handling of purified human immunoglobulin light chain has been studied with an isolated perfused rat kidney preparation. 2. Human immunoglobulin light chain was freely filtered and largely reabsorbed. Fractional reabsorption was characteristic for each of four light chains and varied between 56% and 86%. No renal tubular maximum for human light chain was obtained. 3. Light chains at concentrations up to 10 times those seen in human myeloma were without effect on glomerular filtration rate or sodium and potassium reabsorption in experiments lasting up to 2 h. 4. Filtered and reabsorbed light chain returned ultimately to the perfusion medium, indicating a unique property of the tubular handling of this protein. None of the inhibitors tested (ouabain, frusemide, acetazolamide, probenicid) influenced light chain reabsorption. 5. The results are taken to indicate that light chain reaches the site of the transport enzyme, Na+,K+-dependent ATPase, at concentrations which vary with the nature of the light chain. This may provide a mechanism for renal damage in patients with myeloma, after prolonged exposure.

show abstract

“…Other workers (Rosenthal, Maglio and Moloney, 1972;Greenberger, Rosenthal and Moloney, 1973) have demonstrated in chloroleukaemic and normal rats that only prolonged elevation in serum lysozyme causes lysozymuria and hyperkaluria. Mason, Howes and Taylor (1975) found no tubular maximum (Tm) for resorption of lysozyme in the perfused rat kidney, and lysozymuria occurred even at low perfusate levels of lysozyme.…”

mentioning

confidence: 83%

Lysozyme: a brief review

1977

Postgraduate Medical Journal

View full text Add to dashboard Cite

Summary Serum lysozyme (muramidase) estimation is a simple, convenient and useful laboratory investigation. A review of the literature shows that lysozyme has been implicated as an aetiological factor in various disorders, and credited with being a prognostic indicator in acute myeloid leukaemia, but these promises have not been fulfilled. This low molecular weight protein is found in the urine of some patients with renal tubular disorders, but some workers have emphasized its importance as a causal agent in hypokalaemia of acute myeloid leukaemia. Research should be concentrated on muramidase as an expression of cell functions rather than as an aetiological factor. Hypokalaemia in acute myeloid leukaemia may be caused by an unidentified substance of molecular weight similar to that of lysozyme.

show abstract

Effect of human lysozyme (muramidase) on potassium handling by the perfused rat kidney. A mechanism for renal damage in human monocytic leukaemia.

Cited by 17 publications

References 12 publications

Electrolyte Disorders Associated With Cancer

Electrolyte Disorders Associated With Cancer

Characteristics of Renal Handling of Human Immunoglobulin Light Chain by the Perfused Rat Kidney

Lysozyme: a brief review

Contact Info

Product

Resources

About