Effect of Human Beta Defensin-2 in Epithelial Cell Lines Infected with Respiratory Viruses

Morales, Miguel A.; Alej,; Gutiérrez, ro Escobar; Olvera, Dora Patricia Rosete; Gutiérrez, Carlos Cabello

doi:10.4172/1948-593x.1000135

Cited by 4 publications

(2 citation statements)

References 25 publications

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“…The human lung cells (A549) infected with RSV expressed HBD2 [140]. The expression of the peptide depends on the activation of NF-kB and the action of TNF produced by the virus.…”

Section: Respiratory Syncytial Virus (Vsr)mentioning

confidence: 99%

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Multifunctional Activity of the β-Defensin-2 during Respiratory Infections

Olvera¹,

Gutiérrez²

2019

Immune Response Activation and Immunomodulation

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Human β-defensin-2 is a small cationic peptide that is part of the innate and adaptive immunity. It is expressed mainly in the epithelium and has a broad spectrum of antimicrobial activity against bacteria, fungi and viruses. In addition to its antimicrobial activity, it has other biological functions. The alteration of the expression of β-defensin-2 in the respiratory epithelium has been associated with the pathogenesis of several respiratory diseases such as asthma, pulmonary fibrosis, pneumonia, tuberculosis, rhinitis, etc. The acute respiratory infections caused by viruses are the main cause of morbidity and mortality in the world; there are few studies and it is necessary to study this peptide to understand its role in the viral pathogenesis. In addition, it also becomes relevant in its potential to take advantage of its properties in the development of alternative therapies that allow the prevention or treatment of viral respiratory infections.

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“…The human lung cells (A549) infected with RSV expressed HBD2 [140]. The expression of the peptide depends on the activation of NF-kB and the action of TNF produced by the virus.…”

Section: Respiratory Syncytial Virus (Vsr)mentioning

confidence: 99%

“…Although this disease is benign and with little severity, the infection might be severe in immunosuppressed patients afflicted with HIV and with kidney transplants. The HBD2 inactivates the infection for adenovirus in vitro; the mechanisms of action are not yet known due to lack of in vivo studies [140].…”

Section: Adenovirusmentioning

confidence: 99%