Effect of Hormones on Lymphatic Tissue

Dougherty, Thomas F.

doi:10.1152/physrev.1952.32.4.379

Cited by 490 publications

(137 citation statements)

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“…THE cytolethal effects of glucocorticoid hormones on normal and neoplastic lymphoid cells are well established (Dougherty, 1952; Harris, 1970;Rosenau et al, 1972). Moreover, in combination with other drugs, glucocorticoid hormones are highly effective in the treatment of acute lymphoblastic leukaemia (ALL) of man (Simone, 1974).…”

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Cytoplasmic receptor levels and glucocorticoid response in human lymphoblastoid cell lines

Bird¹,

Waddell²,

Robertson³

et al. 1975

Br J Cancer

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Summary.-The cytolethal response to treatment with prednisolone was investigated in vitro in eight human lymphoblastoid cell lines containing varying concentrations of specific cytoplasmic glucocorticoid receptors. A similar response was observed in seven of the lines irrespective of their concentration of cytoplasmic receptors, and pharmacological doses of steroid, well above those required to saturate receptors in cell-free extracts, were required for a massive lethal response. One cell line derived from Burkitt's lymphoma was refractory to lethal effects even with pharmacological doses of steroid.A similar unresponsiveness to the cytolethal effect of prednisolone in vitro was observed in fresh lymphoblasts derived from patients with acute lymphoblastic leukaemia despite evidence of a satisfactory clinical response to therapy which included steroid. The resistance of human lymphoblastoid cells to treatment with glucocorticoids in vitro may result from a defect in activation subsequent to the binding of steroid to cytoplasmic receptors.

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confidence: 99%

Cytoplasmic receptor levels and glucocorticoid response in human lymphoblastoid cell lines

Bird¹,

Waddell²,

Robertson³

et al. 1975

Br J Cancer

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“…However, the possibility of degenerative changes Ijeing induced in tlie ]}inphoid cells cannot be ruled out in these studies, in \iew of the very high doses of honnone emplo\ed (cf. Dougherty, 1952;Dustuiann and Stolpmann, 1968). More recently.…”

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Influence of Corticotrophic and Corticosteroid Hormones on the Output of Cells From the Popliteal Lymph Node of the Sheep

Shannon

Jones

1974

Aust J Exp Biol Med

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Summary. The intravenous administration of 5, 10 or 20 IU adrenoeorticotrophic hormone (ACTH) resulted in a depression in the output of cells from the popliteal lymph node of the sheep, beginning 60 to 90 minutes after injection. The cell output fell to approximately 40? of the preinjection level with all three doses and the length ()f time the output was depres.sed was dose dependent. The cell output returned (o the preinjectioTi level some 4 hours after 5 IU, 5 hours after 10 IU and 7 hours after 20 IU ACTH had been luhniiiistered. Lymph flow was slightly depressed following 10 IU and 20 IU ACTH. lM)ll()wing the intra\enous adniiiii.stration of 2-5, 5 or 10 mg hydrocortisoiie-21-sodiuin suecinate, there was a reduction in the concentration and output of cells and an inerease in lymph flow, beginning 60 to 90 minutes after injection. All three doses of hydrocortisone ga\'e similar results; eell concentration and output fell to approximately 5()' ,J of the preinjeetion level at 2 hours and returned to normal levels at 4 to 5 hours after administration.The total white cell count in blood rose .' 50 to 45 minutes after the administration of either 20 IU ACTH or 10 mg hydroeortisone and remained above the preinjeetion level over the experimental period. It was concluded that eorticotrophic and eorticosteroid honnones influence the reeireulation of lymphocytes at the level of the local lymph node.INTRODUCTION.

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“…42 The deeper impairment of thymus in our study, in comparison to spleen and lymph nodes, is expressed by its structural loss, which appears as an almost complete destruction A smaller lesion at the medialmost portion of the medial forebrain bundle area (in black), mostly at the suprachiasmatic level, around 0.3 mm wide and deep and slightly less than 1.0 mm along the vertical axis. Abbreviations: ac, anterior commissure; amy, amygdala; c, cingulum; cc, corpus callosum; cg, cingulate gyrus; cp, caudate-putamen; f, fornix; gp, globuls pallidus; Ipo, lateral preoptic nucleus; mfb, medial forebrain bundle; mpo, medial preoptic nucleus; oc, optic chiasm; pm, magnocellular preoptic nucleus; sf, fimbrial spetalnucleus; sl, lateral septal nucleus; st, interstitial nucleus of stria terminalis.…”

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confidence: 50%

Circumscribed lesion of the medial forebrain bundle area causes structural impairment of lymphoid organs and severe depression of immune function in rats

Timo-Iaria

et al. 1998

Mol Psychiatry

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Interactions between the immune system and the brain are a key element in the pathophysiology of diseases such as multiple sclerosis, neuroAIDS, and Alzheimer's, which affect large numbers of individuals and are associated with a high social cost. However, the neuroanatomical basis of brain-immune interactions has not been elucidated. We report that in Wistar rats of either sex bilateral electrolytic lesion of the medial forebrain bundle reduces body weight by 28% 7 days after lesioning, and causes widespread infections, aphagia, adypsia, structural damage to the lymphoid organs and heavy depression of T lymphocytes cytotoxicity. The following alterations occur in the immune system after those lesions: the weight of the thymus, spleen and lymphonodes is reduced by 77.9%, 49.1% and 48.4%, respectively. The thymus is atrophied and contains fewer lymphoid cells in the cortex than in the medulla. In the spleen the white pulp is reduced and lymphoid cells from periarteriolar zones and at the chords are almost absent. In lymph nodes cortical small lymphocytes are depleted and primary and secondary nodules and germinal centers all but disappear. Cytotoxicity of lymphocytes is reduced by 86.2% in the thymus, 77.6% in the spleen and 70.2% in lymph nodes. The critical area of lesion is at the medialmost portion of the medial forebrain bundle, at the preoptic area and rostral part of the anterior hypothalamus. We suggest that this area contains neural circuits that are crucial for keeping the structure of lymphoid organs and the functional integrity of the immune system.

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Effect of Hormones on Lymphatic Tissue

Cited by 490 publications

References 1 publication

Cytoplasmic receptor levels and glucocorticoid response in human lymphoblastoid cell lines

Cytoplasmic receptor levels and glucocorticoid response in human lymphoblastoid cell lines

Influence of Corticotrophic and Corticosteroid Hormones on the Output of Cells From the Popliteal Lymph Node of the Sheep

Circumscribed lesion of the medial forebrain bundle area causes structural impairment of lymphoid organs and severe depression of immune function in rats

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