1998
DOI: 10.1038/sj.mp.4000426
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Circumscribed lesion of the medial forebrain bundle area causes structural impairment of lymphoid organs and severe depression of immune function in rats

Abstract: Interactions between the immune system and the brain are a key element in the pathophysiology of diseases such as multiple sclerosis, neuroAIDS, and Alzheimer's, which affect large numbers of individuals and are associated with a high social cost. However, the neuroanatomical basis of brain-immune interactions has not been elucidated. We report that in Wistar rats of either sex bilateral electrolytic lesion of the medial forebrain bundle reduces body weight by 28% 7 days after lesioning, and causes widespread … Show more

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Cited by 5 publications
(2 citation statements)
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References 32 publications
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“…Descending fibers of the medial forebrain bundle [51] and hippocampus have significant roles in mediating hedonic behavior, and the axonal changes here may contribute to these aspects.…”
Section: Discussionmentioning
confidence: 99%
“…Descending fibers of the medial forebrain bundle [51] and hippocampus have significant roles in mediating hedonic behavior, and the axonal changes here may contribute to these aspects.…”
Section: Discussionmentioning
confidence: 99%
“…62,63 On the other hand, the number of studies is increasing that demonstrate lesions of hypothalamic structures lead to substantial disruptions of the immune system integrity. 64 However, considering that limited observations on the complex interactions of CNS tissue, neurotransmitters and cytokines are presently possible, caution must be exercised in interpreting psycho-immunological data, particularly since, despite considerable research, the mechanisms underlying the aberrant immune functions of PBMC from schizophrenics are as yet not understood at the cellular level.…”
Section: Production Of: Il-2 (T1) Il-2 (T2) Il-2 (T3) Ifn-␥ (T1) Ifn-mentioning
confidence: 99%