Effect of hormonal and copper IUDs on genital microbial colonisation and clinical outcomes in North-Western Nigeria

Saidu, Abdulhadi Diyo; Tunau, K; Panti, A; Nwobodo, EI; Mohammed, Yahaya; Amin, Jamila; Garba, Jamila Abubakar

doi:10.18203/2320-1770.ijrcog20172304

Cited by 4 publications

(3 citation statements)

References 6 publications

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“…11 But our study is supported by Sharon L Hillier, Michele Austin et al 12 In present study regarding characteristic of discharge, Curdy discharge was present 61.25%, frothy discharge was present 16.25% and homogeneous charge was present in 17.5%. This is supported by the study of Venugopal S, Gopalan K, Devi A, Kavitha A et al 13 In our study lower abdominal pain was most common followed by dysuria and dyspareunia which corroborates with the study of Narayankhedkar A, Hodiwala A, Mane A et al and Saidu AD, Tunau KA, Panti AA, Nwobodo EI, Mohammed Y, Amin J, et al 14,15 Regarding clinical finding in patients changes in vulva was most common clinical finding followed by vaginal erythema and cervical changes. In most of the patient the discharge was purulent and in 30 5 patients it was profuse.…”

Section: Discussionsupporting

confidence: 90%

Clinicomicrobiological spectrum of abnormal discharge from vagina in women in costal Andhra Pradesh

Singamsetty¹,

Sravani²

2020

Int J Reprod Contracept Obstet Gynecol

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Background: When there is change in colour, consistency, order and volume of discharge then it is called abnormal vaginal discharge and associated with vulvar pruritus, dyspareunia, dysuria and lower abdominal pain. There is variability in organism isolated and treatment used.Methods: Sexually active women in reproductive age group with complain of abnormal vaginal discharge were included in this study based in following inclusion and exclusion criteria. . A detailed history of patient was taken regarding nature of discharge, colour, smell along with dysuria, dyspareunia, itching of vulva and lower abdominal pain.Results: Out of 160 patients 88 patients have bacterial vaginosis. Trichomonas vaginitis was present in 7.5% patients. Candidiasis was present in 6.25% patients. Some patients were having more than one infection like Bacterial vaginosis and Trichomonas vaginitis was coexisting in 13.75%, Bacterial vaginosis + Candidiasis were present in 8.75% patients. Mixed infection was present in 8.75%.Conclusions: From present study we can conclude that vaginal discharge is more common in married women in young age. Patients commonly presented with curdy white discharge, pruritus vulva and lower abdominal pain. Erythema and excoriation in vulva were common presentation, followed by erythema of vagina. Nature of discharge was mucopurulent in most patients. Bacterial vaginosis was most common followed by Trichomonas vaginitis.

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Section: Discussionsupporting

confidence: 90%

Clinicomicrobiological spectrum of abnormal discharge from vagina in women in costal Andhra Pradesh

Singamsetty¹,

Sravani²

2020

Int J Reprod Contracept Obstet Gynecol

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“…Madden et al (2012) found the incidence of BV was 37.0% among IUD users and 19.3% in combined oral contraceptives, ring and patch users. 22 Joesoef MR et al, found the prevalence of bacterial vaginosis in 47.2% of cases of IUD users and 26.6% in cases of other hormonal contraceptive users. 23 In this study 25.6% cases with bacterial vaginosis were pregnant.…”

Section: Resultsmentioning

confidence: 98%

Clinical presentation, diagnosis and management of bacterial vaginosis: a hospital based cross-sectional study

Agarwal¹,

Soni²,

Singh³

2020

Int J Reprod Contracept Obstet Gynecol

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Background: Bacterial vaginosis is most common cause of vaginal discharge. Clinical presentation varies from person to person. The management of bacterial vaginosis is largely syndromic and empirical, it is usually based on naked eye examination of vaginal discharge and that is unsatisfactory because the diagnostic accuracy is lost without microscopic examination. The modern management of bacterial vaginosis demands a specific diagnosis which is a combination of naked eye examination plus laboratory workup.Methods: The study was carried out on 183 females with complaint of vaginal discharge in the outpatient department of obstetrics and gynecology. Specimens were collected in outpatient department of Jhalawar Medical College in associated Zanana Hospital. The laboratory work was conducted in the department of microbiology in Jhalawar Medical College, Jhalawar, Rajasthan, India.Results: The prevalence of microbial positivity in our study was 79.9%. Bacterial vaginosis was the most common diagnosis seen in 86 (47.0%) cases. Maximum patients presented with complaint of copious amount of foul-smelling yellow discharge.Conclusions: The study concludes that it is important to know the various presentations, confirm the diagnosis by proper microbiological tests, and provide appropriate treatment to patients to prevent resistance and recurrence of bacterial vaginosis.

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“…During IUD use, IUD has been colonized by anaerobic and aerobic bacteria and change the genital tract microbiota, which then may increase the prevalence of genital tract infection [7][8][9]. 9% of the bacterial species that human body hosts are associated with the urogenital tract [10].…”

Section: Introductionmentioning

confidence: 99%

Potential Use of Lactobacillus gasseri G10 Isolated from Human Vagina along with Intrauterine Devices (IUD) to Prevent Pathogen Colonization

Aktaş

2022

Sakarya University Journal of Science

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Intrauterine devices (IUDs), well effective long-term contraception methods used around the world, are potential reservoir for pathogens and carry risk of reproductive-tract infections such as bacterial vaginosis and vulvovaginal candidiasis. A healthy vagina is dominated by Lactobacillus involved in protecting reproductive system against pathogens. This study aims to investigate the impact of L. gasseri G10 (G10), a vaginal isolate, and its Exopolysaccharide (EPS) on adherence of Staphylococcus aureus and Candida albicans to IUD-tail. Three conditions were simulated to examine if G10 with/without EPS is capable of displacing, excluding, and competing pathogen adhesion to IUD. Inhibitory impact of EPS at various concentrations on pathogen adherence was also evaluated with co-incubation. G10 blocked by co-incubation (97%) and displacement (46%) of S. aureus adherence to IUD tail and displaced C. albicans attached to IUD with about 99%. Compared with S. aureus, the biofilm formation by C. albicans was highly susceptible to EPS. All concentrations of EPS inhibited the adherence of C. albicans (81-97%); however, no significant reductions were observed in S. aureus adherence. Moreover, G10 and EPS together reduced the adherence of both S. aureus (>99%) and C. albicans (94-98%) through all three mechanisms. This study indicates that G10 and its EPS have the ability to inhibit adhesion of S. aureus and C. albicans to IUD and potential use in intravaginal products to prevent/manage IUD associated infections in women. The results suggest development of a new way of applying IUD along with probiotic agents alone or as synbiont.

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Effect of hormonal and copper IUDs on genital microbial colonisation and clinical outcomes in North-Western Nigeria

Cited by 4 publications

References 6 publications

Clinicomicrobiological spectrum of abnormal discharge from vagina in women in costal Andhra Pradesh

Clinicomicrobiological spectrum of abnormal discharge from vagina in women in costal Andhra Pradesh

Clinical presentation, diagnosis and management of bacterial vaginosis: a hospital based cross-sectional study

Potential Use of Lactobacillus gasseri G10 Isolated from Human Vagina along with Intrauterine Devices (IUD) to Prevent Pathogen Colonization

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