Clinical presentation, diagnosis and management of bacterial vaginosis: a hospital based cross-sectional study

Agarwal, Manju; Soni, Rakhee; Singh, Adhunika

doi:10.18203/2320-1770.ijrcog20201222

Cited by 2 publications

(3 citation statements)

References 13 publications

(25 reference statements)

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“…With vaginal discharge and itch being the commonest clinical presentations and coupled with recurrent symptoms, we speculate that a high usage of vaginitis (VVC and BV-TV) treatment with delayed opportunity for STI treatment over the years may explain these variations. Our detection of an infection in two-thirds of patients is similar to proportions in studies from elsewhere in Africa [ 8 , 9 ], but somewhat lower than studies from India (80%) [ 7 ]. For the specific female genital infections, our findings do not concur with other studies from Africa where BV was predominant [ 2 , 8 , 9 , 17 ].…”

Section: Discussionsupporting

confidence: 85%

“…Common symptoms associated with lower genital tract infections (LGTI) include vaginal discharge, dysuria, lower abdominal pain, dyspareunia, and pruritus. Vaginal discharge is commonest among these, being present in up to 75% of women with LGTI [ 6 , 7 ]. However, these symptoms are not specific for LGTI, for example, in sub-Saharan African studies 27–49% of women with vaginal discharge did not have an infection [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation and optimization of the syndromic management of female genital tract infections in Nairobi, Kenya

Omosa-Manyonyi,

de Kam,

Tostmann

et al. 2023

BMC Infect Dis

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Background Genital tract infections pose a public health concern. In many low-middle-income countries, symptom-based algorithms guide treatment decisions. Advantages notwithstanding, this strategy has important limitations. We aimed to determine the infections causing lower genital tract symptoms in women, evaluated the Kenyan syndromic treatment algorithm for vaginal discharge, and proposed an improved algorithm. Methods This cross-sectional study included symptomatic non-pregnant adult women presenting with lower genital tract symptoms at seven outpatient health facilities in Nairobi. Clinical, socio-demographic information and vaginal swabs microbiological tests were obtained. Multivariate logistic regression analyses were performed to find predictive factors for the genital infections and used to develop an alternative vaginal discharge treatment algorithm (using 60% of the dataset). The other 40% of data was used to assess the performance of each algorithm compared to laboratory diagnosis. Results Of 813 women, 66% had an infection (vulvovaginal candidiasis 40%, bacterial vaginosis 17%, Neisseria gonorrhoea 14%, multiple infections 23%); 56% of women reported ≥ 3 lower genital tract symptoms episodes in the preceding 12 months. Vulvovaginal itch predicted vulvovaginal candidiasis (odds ratio (OR) 2.20, 95% CI 1.40–3.46); foul-smelling vaginal discharge predicted bacterial vaginosis (OR 3.63, 95% CI 2.17–6.07), and sexually transmitted infection (Neisseria gonorrhoea, Trichomonas vaginalis, Chlamydia trachomatis, Mycoplasma genitalium) (OR 1.64, 95% CI 1.06–2.55). Additionally, lower abdominal pain (OR 1.73, 95% CI 1.07–2.79) predicted sexually transmitted infection. Inappropriate treatment was 117% and 75% by the current and alternative algorithms respectively. Treatment specificity for bacterial vaginosis/Trichomonas vaginalis was 27% and 82% by the current and alternative algorithms, respectively. Performance by other parameters was poor to moderate and comparable between the two algorithms. Conclusion Single and multiple genital infections are common among women presenting with lower genital tract symptoms at outpatient clinics in Nairobi. The conventional vaginal discharge treatment algorithm performed poorly, while the alternative algorithm achieved only modest improvement. For optimal care of vaginal discharge syndrome, we recommend the inclusion of point-of-care diagnostics in the flowcharts.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Evaluation and optimization of the syndromic management of female genital tract infections in Nairobi, Kenya

Omosa-Manyonyi,

de Kam,

Tostmann

et al. 2023

BMC Infect Dis

View full text Add to dashboard Cite

show abstract

“…With vaginal discharge and itch being the commonest clinical presentations and coupled with recurrent symptoms, we speculate that a high usage of vaginitis (VVC and BV-TV) treatment with delayed opportunity for STI treatment over the years may explain these variations. Our detection of an infection in two-thirds of patients is similar to proportions in studies from elsewhere in Africa (8, 9), but somewhat lower than studies from India (80%) (7). For the speci c female genital infections, our ndings do not concur with other studies from Africa where BV was predominant (2,8,9,17).…”

Section: Discussioncontrasting

confidence: 56%

Evaluation and optimization of the syndromic management of female genital tract infections in Nairobi, Kenya

Omosa-Manyonyi

Kam

Tostmann

et al. 2022

Preprint

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Background Genital tract infections pose a public health concern. In many low-middle-income countries, symptom-based algorithms guide treatment decisions. Advantages notwithstanding, this strategy has important limitations. We aimed to determine the infections causing lower genital tract symptoms in women, evaluated the Kenyan syndromic treatment algorithm for vaginal discharge, and proposed an improved algorithm. Methods This cross-sectional study included symptomatic non-pregnant adult women presenting with lower genital tract symptoms at seven outpatient health facilities in Nairobi. Clinical, socio-demographic information and vaginal swabs microbiological tests were obtained. Multivariate logistic regression analyses were performed to find predictive factors for the genital infections and used to develop an alternative vaginal discharge treatment algorithm (using 60% of the dataset). The other 40% of data was used to assess the performance of each algorithm compared to laboratory diagnosis. Results Of 813 women, 66% had an infection (vulvovaginal candidiasis 40%, bacterial vaginosis 17%, Neisseria gonorrhoea 14%, multiple infections 23%; 56% of women reported ≥ 3 lower genital tract symptoms episodes in the preceding 12 months. Vulvovaginal itch predicted vulvovaginal candidiasis (odds ratio (OR) 2.20, 95% CI 1.40–3.46); foul-smelling vaginal discharge predicted bacterial vaginosis (OR 3.63, 95% CI 2.17–6.07), and sexually transmitted infection (Neisseria gonorrhoea, Trichomonas vaginalis, Chlamydia trachomatis, Mycoplasma genitalium) (OR 1.64, 95% CI 1.06–2.55). Additionally, contraceptive use (OR 2.27, 95% CI 1.06–4.88) and lower abdominal pain (OR 1.73, 95% CI 1.07–2.79) predicted sexually transmitted infection. Inappropriate treatment was 117% and 75% by the current and alternative algorithms respectively. Treatment specificity for bacterial vaginosis/Trichomonas vaginalis was 27% and 82% by the current and alternative algorithms, respectively. Performance by other parameters was poor to moderate and comparable between the two algorithms. Conclusion Single and multiple genital infections are common among women presenting with lower genital tract symptoms at outpatient clinics in Nairobi. The conventional vaginal discharge treatment algorithm performed poorly, while the alternative algorithm achieved only modest improvement. For optimal care of vaginal discharge syndrome, we recommend the inclusion of point-of-care diagnostics in the flowcharts.

show abstract

Clinical presentation, diagnosis and management of bacterial vaginosis: a hospital based cross-sectional study

Cited by 2 publications

References 13 publications

Evaluation and optimization of the syndromic management of female genital tract infections in Nairobi, Kenya

Evaluation and optimization of the syndromic management of female genital tract infections in Nairobi, Kenya

Evaluation and optimization of the syndromic management of female genital tract infections in Nairobi, Kenya

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