Effect of Homocysteine Reduction by B-Vitamin Supplementation on Markers of Clotting Activation

Klerk, Mariska; Verhoef, Petra; Verbruggen, Bert; Schouten, Evert G.; Blom, Henk J.; Bos, Gerard M.J.; Heijer, Martin den

doi:10.1055/s-0037-1613192

Cited by 17 publications

(12 citation statements)

References 32 publications

(48 reference statements)

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“…In multivariate analysis the association of homocysteine and D-dimer remains statistically significant after adjustment for indicators of chronic inflammation and fibrinogen in previous studies. 22,23 These results are consistent with our study in which we showed a significant correlation between homocysteine and D-dimer levels. In their study Sciacca et al showed that D-dimer and homocysteine concentrations were not different between the control group and MS patients but the patients in that study were under immunomodulatory therapy.…”

Section: Discussionsupporting

confidence: 92%

Coagulation status and biochemical and inflammatory markers in multiple sclerosis

Aksungar¹,

Topkaya²,

Yıldız³

et al. 2008

Journal of Clinical Neuroscience

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Section: Discussionsupporting

confidence: 92%

Coagulation status and biochemical and inflammatory markers in multiple sclerosis

Aksungar¹,

Topkaya²,

Yıldız³

et al. 2008

Journal of Clinical Neuroscience

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“…Greater improvements in folate and tHcy status were obtained with our present short-term, low dosage (800 mg/ day) folic acid supplementation than in earlier studies using 5-10 mg of folic acid for periods of 6 weeks (Landgren et al, 1995;Klerk et al, 2002) and 2 months (Brouwer et al, 1999). Serum folate and plasma tHcy concentrations were relatively low in our young male subjects, though six participants showed mild hyperhomocysteinemia at the beginning of the study, and four of the six had no genetic risk factors.…”

Section: Discussioncontrasting

confidence: 58%

Effects of short-term folic acid and/or riboflavin supplementation on serum folate and plasma total homocysteine concentrations in young Japanese male subjects

et al. 2005

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Objective: To investigate the effects of short-term folic acid and/or riboflavin supplementation on serum folate and plasma plasma total homocysteine (tHcy) concentrations in young Japanese male subjects. Design: In a double blind, randomized controlled trial. Intervention: Subjects were randomly assigned to one of four groups and received a placebo (control group), 800 mg/day folic acid (FA group), 8.4 mg/day riboflavin (R group), or both (FAR group) for 2 weeks. Setting: Tokyo, Japan. Subjects: In total, 32 healthy male volunteers aged 20-29 years. Results: At the end of the 2 week supplementation period, the tHcy concentration decreased significantly in the FA group. Serum folate concentrations had increased between 2.7 and 2.0-fold in the FA and FAR groups, respectively, but the mean within-group changes in serum folate and plasma tHcy concentrations did not differ between these two groups. At the end of the study, alanine amino transferase was decreased in the R and FAR groups, while alanine amino transferase was increased in the FA group. Conclusion: Supplementation with folic acid, 800 mg/day, for 2 weeks, increased the serum and red blood cell folate concentrations and decreased the plasma tHcy concentrations in healthy young male subjects. Riboflavin supplementation may have blunted the effect of folic acid, which resulted in a diminished reduction of tHcy in our subjects.

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“…During Ramadan fasting at least one meal is omitted, hence a possible increase in FVIIc activity after lunch may not be seen. Moreover, associations between homocysteine and fi brin D -dimer are under investigation in recent studies, while in multivariate analysis the association of homocysteine and D -dimer is demonstrated to remain statistically signifi cant after adjustment for indicators of chronic infl ammation and fibrinogen [20,21] . These results are consistent with our study in which we showed a signifi cant decrease in D -dimer levels indicating fi brin generation in the body was decreased during intermittent fasting.…”

Section: Discussionmentioning

confidence: 99%

Effects of Intermittent Fasting on Serum Lipid Levels, Coagulation Status and Plasma Homocysteine Levels

Aksungar¹,

Eren

Ure

et al. 2005

Ann Nutr Metab

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Background: During Ramadan, Muslims fast during the daylight hours for a month. The duration of restricted food and beverage intake is approximately 12 h/day which makes Ramadan a unique model of intermittent fasting. Many physiological and psychological changes are observed during Ramadan that are probably due to the changes in eating and sleeping patterns. Methods: Serum total cholesterol, triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL), prothrombin time, activated partial thromboplastin time (aPTT), plasma fibrinogen, D-dimer and homocysteine levels were measured in 24 healthy fasting volunteers (12 females, 12 males) aged 21–35 years. Venous blood samples were taken 1 week before Ramadan, on the 21st day of Ramadan and 20 days after Ramadan. Results: No significant changes were observed on serum total cholesterol, triglycerides and LDL levels. HDL levels were significantly elevated during Ramadan (p < 0.001) and 20 days after Ramadan (p < 0.05). Prothrombin time, aPTT, fibrinogen and D-dimer levels were in the physiologic limits in all samples but D-dimer levels were significantly low at the end of Ramadan in comparison to pre- and post-fasting levels (p < 0.001). Homocysteine levels, being still in reference ranges, were low during Ramadan (p < 0.05) and reached the pre-fasting levels after Ramadan. Conclusion: Our results demonstrate that intermittent fasting led to some beneficial changes in serum HDL and plasma homocysteine levels, and the coagulation status. These changes may be due to omitting at least one meal when the body was particularly metabolically active and possibly had a low blood viscosity level at the same time. We conclude that intermittent fasting may have beneficial effects on hemostatic risk markers for cardiovascular diseases.

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Effect of Homocysteine Reduction by B-Vitamin Supplementation on Markers of Clotting Activation

Cited by 17 publications

References 32 publications

Coagulation status and biochemical and inflammatory markers in multiple sclerosis

Coagulation status and biochemical and inflammatory markers in multiple sclerosis

Effects of short-term folic acid and/or riboflavin supplementation on serum folate and plasma total homocysteine concentrations in young Japanese male subjects

Effects of Intermittent Fasting on Serum Lipid Levels, Coagulation Status and Plasma Homocysteine Levels

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