Effects of short-term folic acid and/or riboflavin supplementation on serum folate and plasma total homocysteine concentrations in young Japanese male subjects

Araki, Ryosuke; Maruyama, Chizuko; Igarashi, Shigeru; Yoshida, Masao; Maruyama, Taro; Satoh, Tomoko; Umegaki, Keizo

doi:10.1038/sj.ejcn.1602351

Cited by 26 publications

(16 citation statements)

References 43 publications

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“…The increase, 23.0 ± 30.6 nmol/L (mean ± SD), in the concentration of serum folate and a decrease, 0.7 ± 1.4 lmol/L (mean ± SD), in the concentration of p-tHcy after folic acid supplementation, 0.8 mg/day, for 2 weeks, are similar to the findings, in healthy subjects, reported previously, increase in serum folate 18.0 ± 1.5 nmol/L (mean ± SD) and a decrease in p-tHcy 0.9 ± 0.4 lmol/L (mean ± SD) (Araki et al 2006). It has also been demonstrated that folic acid dose, 0.8 mg/day given to healthy subjects, for 12 weeks, increased the concentration of serum folate from 12.9 ± 3.6 to 53.4 ± 28.3 nmol/L (mean ± SD) and reduced the concentration of p-tHcy from 11.5 ± 2.8 to 9.6 ± 2.2 lmol/(mean ± SD) (change about 25 %) (Van Oort et al 2003).…”

Section: Discussionsupporting

confidence: 77%

Effect of genetic polymorphisms involved in folate metabolism on the concentration of serum folate and plasma total homocysteine (p-tHcy) in healthy subjects after short-term folic acid supplementation: a randomized, double blind, crossover study

et al. 2015

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Effect of genetic polymorphisms involved in folate metabolism on the concentration of serum folate and plasma total homocysteine (p-tHcy) in healthy subjects after short-term folic acid supplementation: a randomized, double blind, crossover study Abstract Data on the effect of combined genetic polymorphisms, involved in folate metabolism, on the concentration of serum folate after folic acid supplementation are scarce. Therefore, we investigated the impact of seven gene polymorphisms on the concentration of serum folate and p-tHcy in healthy subjects after short-term folic acid supplementation. In a randomized, double blind, crossover study, apparently healthy subjects were given either 0.8 mg folic acid per day (n = 46) or placebo (n = 45) for 14 days. The washout period was 14 days. Fasting blood samples were collected on day 1, 15, 30 and 45. Data on subjects on folic acid supplementation (n = 91) and on placebo (n = 45) were used for the statistical analysis. The concentration of serum folate increased higher in subjects with higher age (53.5 ± 7.0 years) than in subjects with lower age (24.3 ± 3.2 years) after folic acid supplementation (p = 0.006). The baseline concentration of serum folate in subjects with polymorphism combination, reduced folate carrier protein, RFC1-80 GA and methylenetetrahydrofolate reductase, MTHFR677 CT?TT, was lower than RFC1-80 AA and MTHFR677 CT?TT (p = 0.002). After folic acid supplementation, a higher increase in the concentration of serum folate was detected in subjects with polymorphism combination RFC1-80 GA and MTHFR677 CC than RFC1-80 GG and MTHFR CT?TT combination (p \ 0.0001). The baseline concentration of plasma total homocysteine (p-tHcy) was altered by combined polymorphisms in genes associated with folate metabolism. After folic acid supplementation, in subjects with combined polymorphisms in methylenetetrahydrofolate dehydrogenase, MTHFD1-1958 and MTHFR-677 genes, the concentration of p-tHcy was changed (p = 0.002). The combination of RFC1-80 and MTHFR-677 polymorphisms had a profound affect on the concentration of serum folate in healthy subjects before and after folic acid supplementation.

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Section: Discussionsupporting

confidence: 77%

Effect of genetic polymorphisms involved in folate metabolism on the concentration of serum folate and plasma total homocysteine (p-tHcy) in healthy subjects after short-term folic acid supplementation: a randomized, double blind, crossover study

et al. 2015

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“…It has been proposed that it acts jointly with folate to lower plasma homocysteine levels. One Japanese study reported that low riboflavin blunted the effect of folic acid, which resulted in a diminished reduction of total homocysteine (33). Conversely, high intake of folic acid supplements was observed to exacerbate a tendency toward riboflavin deficiency (34).…”

Section: Discussionmentioning

confidence: 99%

Dietary Folate Intake,MTHFRGenetic Polymorphisms, and the Risk of Endometrial Cancer among Chinese Women

Wang¹,

Shrubsole²,

Xiang³

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Folate plays an important role in carcinogenesis. The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR), encoded by the MTHFR gene, is involved in this process. We investigated both the independent and joint effects of dietary folate and other methyl-related nutrients, as well as three polymorphisms of MTHFR (677C>T, 1298A>C, and 1793G>A), on endometrial cancer risk in a population-based case-control study. Between 1997 and 2003, 1,204 newly diagnosed endometrial cancer cases and 1,212 controls were recruited among women between the ages of 30 and 69 years in urban Shanghai, China. Information on dietary intake of folate and other methyl-related nutrients, including vitamin B2 (riboflavin), vitamin B6, vitamin B12, and methionine, was derived from a validated food frequency questionnaire. Genotyping was completed on 1,041 cases and 1,030 controls for MTHFR 677C>T (rs1801133), 1298A>C (rs1801131), and 1793 G>A (rs22749746). Haplotype estimation of the three single-nucleotide polymorphisms was performed using PHASE software. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated to evaluate associations of nutrients, MTHFR genotypes, and haplotypes with endometrial cancer risk. A significant inverse association between dietary folate intake and endometrial cancer risk was observed among all subjects and non -B vitamin supplement users. The greatest reduction in endometrial cancer risk was observed among non-users of supplements in the highest quartile of dietary folate intake (OR, 0.5; 95% CI, 0.4-0.7) as compared with those in the lowest quartile. Dietary intake of folate cofactors (methionine, vitamin B2, vitamin B6, and vitamin B12) was not related to risk of endometrial cancer. No association was observed between endometrial cancer and the MTHFR 677C>T, 1298 A>C, and 1793G>A polymorphisms or derived haplotypes. Among non-users of supplements, however, the 1298C and 1793A alleles were associated with a lower risk of endometrial cancer among women with high dietary folate intake but related to a higher risk among those with low dietary folate intake (P interaction = 0.08 and 0.03, respectively). Further analysis showed that the lowest risk (OR, 0.6; 95% CI, 0.4-1.1) was among women with the 1298C allele and the highest intake of both folate and riboflavin (P interaction = 0.04). A similar association was observed for the 1793A allele (P interaction = 0.03). Our findings suggest that folate intake may decrease the risk of endometrial cancer and modify the effect of MTHFR polymorphisms on risk. (Cancer Epidemiol Biomarkers Prev 2007;16(2):281 -7)

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“…Secondly, we did not measure nutritional status, that is, serum concentrations of folate and vitamins B 12 , which could affect homocysteine metabolism [38]. Previous studies described that supplementation with folic acid increased the serum and red blood cell folate concentrations and decreased the plasma tHcy concentrations in healthy young Japanese male subjects [39]. Thus, it remains uncertain whether nutritional status could affect the presence of WML in RA patients.…”

Section: Discussionmentioning

confidence: 98%

The role of homocysteine as a significant risk factor for white matter lesions in Japanese women with rheumatoid arthritis

et al. 2009

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Effects of short-term folic acid and/or riboflavin supplementation on serum folate and plasma total homocysteine concentrations in young Japanese male subjects

Cited by 26 publications

References 43 publications

Effect of genetic polymorphisms involved in folate metabolism on the concentration of serum folate and plasma total homocysteine (p-tHcy) in healthy subjects after short-term folic acid supplementation: a randomized, double blind, crossover study

Effect of genetic polymorphisms involved in folate metabolism on the concentration of serum folate and plasma total homocysteine (p-tHcy) in healthy subjects after short-term folic acid supplementation: a randomized, double blind, crossover study

Dietary Folate Intake,MTHFRGenetic Polymorphisms, and the Risk of Endometrial Cancer among Chinese Women

The role of homocysteine as a significant risk factor for white matter lesions in Japanese women with rheumatoid arthritis

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