Effect of histamine, albuterol and deep inspiration on airway and lung tissue mechanics in cynomolgus monkeys

Chapman, Richard W.; Skeans, Susan; Lamca, James; House, Aileen; Hey, John A.; Celly, Chander

doi:10.1016/j.pupt.2004.12.007

Cited by 11 publications

(3 citation statements)

References 33 publications

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“…The forced oscillation technique (FOT) has been widely used to measure the impedance of the respiratory system in dogs (3)(4)(5)(6), rats (7), monkeys (8)(9)(10)(11) and human infants (12). By measuring lung impedance over a wide range of frequencies, it is possible to separate the components of the system impedance into airway and tissue components.…”

Section: Introductionmentioning

confidence: 99%

Differential Effects of Dexamethasone on the Proximal and Distal Lung Response to Antigen Challenge in Allergic Cynomolgus Monkeys

Curran¹,

Skeans²,

Landers³

et al. 2008

Journal of Asthma

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The proximal and distal portions of the lungs may respond differently to antigen challenge and bronchodilator treatment. This difference may contribute to differences in actual and perceived efficacy of therapies. In this study we used the forced oscillation technique (FOT) to measure impedance in the pulmonary system and discern the effects of antigen challenge on proximal (large airway) and distal (small airway and lung parenchyma) portions of the lung. In addition we treated the animals with two i.m. injections of either a saline control or dexamethasone (0.5 mg/kg) 18 and 1 hour(s) before the antigen challenge. The FOT technique was used to measure indices of proximal airway status, Newtonian airway resistance (R(N)), and distal airway status, including tissue damping (G) and tissue elastance (H). Challenging the animals with Ascaris Suum antigen caused a significant increase in both the proximal and distal lung measures. Pretreatment with dexamethasone significantly reduced the peak increase in R(N) but not G or H. In addition, the area under the curve (AUC) of the FOT response over 60 minutes was significantly reduced for the R(N) but again, G and H were not significantly reduced. These data indicate that, using the FOT, we can dissociate the response of proximal and distal airways to an antigen challenge. Moreover, steroid pre-treatment can reduce the bronchoconstrictor response to inhaled antigen but this effect is primarily via effects on the proximal airways with little effect on the distal airways and parenchymal component of pulmonary impedance. These data may help to provide a mechanism for evaluation of novel therapies for small airway dysfunction.

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Section: Introductionmentioning

confidence: 99%

Differential Effects of Dexamethasone on the Proximal and Distal Lung Response to Antigen Challenge in Allergic Cynomolgus Monkeys

Curran¹,

Skeans²,

Landers³

et al. 2008

Journal of Asthma

Self Cite

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“…Respiratory rate and other measures of respiratory function (e.g., tidal volume or hemoglobin oxygen saturation) should be evaluated. Initial assessment can be performed in NHPs using head-out or whole-body plethysmography (Iizuka et al 2010;Lawler et al 2006;Nalca et al 2010), and follow-up evaluation, such as measurement of pulmonary resistance, can be done in anesthetized animals (Chapman et al 2005;Skeans et al 2005;Curran et al 2008). 7.3, ICH 7A 2000).…”

Section: Respiratory System Safety Pharmacologymentioning

confidence: 99%

Principles of Safety Pharmacology

2015

Handbook of Experimental Pharmacology

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“…Pulmonary mechanics and their relation to histamine have been studied in many other species and it is clear that histamine-induced bronchial smooth muscle contraction and acute bronchospasm are common. [61][62][63][64][65][66][67][68] The pathogenesis of asthma is complex and all symptomatology cannot be accounted for by a single histamine-dependent mechanism. This explains the disappointing results when histamine antagonists are used as sole therapy for asthma in humans and cats.…”

Section: Histamine Measurementmentioning

confidence: 99%

Histamine: metabolism, physiology, and pathophysiology with applications in veterinary medicine

Peters

Kovacic

2009

J Vet Emergen Crit Care

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Histamine plays a key role in the morbidity and mortality associated with allergy, asthma, gastric ulcers, anaphylaxis, sepsis, hemorrhagic shock, anesthesia, surgery, cardiovascular disease, cancer, CNS disorders, and immune-mediated disease. Histamine antagonism has been in common use to block its adverse effects. With recent advances in the understanding of histamine receptor physiology, pharmaceutical agents targeting these receptors have increased the therapeutic options.

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Effect of histamine, albuterol and deep inspiration on airway and lung tissue mechanics in cynomolgus monkeys

Cited by 11 publications

References 33 publications

Differential Effects of Dexamethasone on the Proximal and Distal Lung Response to Antigen Challenge in Allergic Cynomolgus Monkeys

Differential Effects of Dexamethasone on the Proximal and Distal Lung Response to Antigen Challenge in Allergic Cynomolgus Monkeys

Principles of Safety Pharmacology

Histamine: metabolism, physiology, and pathophysiology with applications in veterinary medicine

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