Effect of high pressure homogenization on physicochemical properties of curcumin nanoparticles prepared by antisolvent crystallization using HPMC or PVP

Homayouni, Alireza; Sohrabi, Masoumeh; Amini, Marjan; Varshosaz, Jaleh; Nokhodchi, Ali

doi:10.1016/j.msec.2018.12.128

Cited by 23 publications

(18 citation statements)

References 42 publications

(70 reference statements)

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“…The high cumulative dissolution and rapid release of nanosuspensions compared with those of pure isoliquiritigenin may be attributed to the small particle size and large specific surface area of nanoparticles, as confirmed by Gol et al [28]. In addition, Homayouni et al [29] reported that the presence of hydrophilic stabilizer is beneficial in enhancing the solubility properties of insoluble drugs, and Yakushiji et al [30] have verified that wet milling with a lower viscosity of HPC SSL improves the in vitro release. In addition, the improvement in dissolution may be associated with the crystal form of the nanoparticles.…”

Section: Resultsmentioning

confidence: 86%

Isoliquiritigenin Nanosuspension Enhances Cytostatic Effects in A549 Lung Cancer Cells

et al. 2020

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Isoliquiritigenin, a flavonoid extracted from licorice root, has been shown to be active against most cancer cells; however, its antitumor activity is limited by its poor water solubility. The aim of this study was to develop a stable isoliquiritigenin nanosuspension for enhanced solubility and to evaluate its in vitro cytostatic activity in A549 cells. The nanosuspension of isoliquiritigenin was prepared through wet media milling with HPC SSL (hydroxypropyl cellulose-SSL) and PVP K30 (polyinylpyrrolidone-K30) as stabilizers, and the samples were then characterized according to particle size, zeta-potential, SEM (scanning electron microscopy), TEM (transmission electron microscopy), DSC (differential scanning calorimetry), XRPD (X-ray powder diffraction), FTIR (Fourier transform infrared spectroscopy), XPS (X-ray photoelectron spectroscopy), and in vitro release. The isoliquiritigenin nanosuspension prepared with HPC SSL and PVP K30 had particle sizes of 238.1 ± 4.9 nm and 354.1 ± 9.1 nm, respectively. Both nanosuspensions showed a surface charge of approximately − 20 mV and a lamelliform or ellipse shape. The dissolution of isoliquiritigenin from the 2 nanosuspensions was markedly higher than that of free isoliquiritigenin. In vitro studies on A549 cells indicated that the cytotoxicity and cellular uptake significantly improved after treatment with both nanosuspensions in comparison to the isoliquiritigenin solution. Furthermore, cell apoptosis analysis showed a 7.5 – 10-fold increase in the apoptosis rate induced by both nanosuspensions compared with pure drug. However, the cytotoxicity of pure drug and nanosuspension on normal cells (HELF) was lower, which indicated both isoliquiritigenin nanosuspensions have low toxicity to normal cells. Therefore, the isoliquiritigenin nanosuspension prepared with HPC SSL and PVP K30 as stabilizers may be a promising approach to improve the solubility and cytostatic activity of isoliquiritigenin.

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Section: Resultsmentioning

confidence: 86%

Isoliquiritigenin Nanosuspension Enhances Cytostatic Effects in A549 Lung Cancer Cells

et al. 2020

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“…The time of dissolution was shortened from circa 20 min for curcumin alone to circa 7 min for the nanoparticles with pVP. Moreover, the examinations revealed that pVP inhibited the aggregation of the particles and that the connection between Cur and pVP is realized by hydrogen bonding [ 88 ]. The literature papers report that anticancer curcumin acts like inhibitor for STAT3 and NF-κB signaling pathways, which plays the main role in cancer development.…”

Section: Pvp In Micro- and Nano Drug Delivery Systemsmentioning

confidence: 99%

Activity of Povidone in Recent Biomedical Applications with Emphasis on Micro- and Nano Drug Delivery Systems

2021

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Due to the unwanted toxic properties of some drugs, new efficient methods of protection of the organisms against that toxicity are required. New materials are synthesized to effectively disseminate the active substance without affecting the healthy cells. Thus far, a number of polymers have been applied to build novel drug delivery systems. One of interesting polymers for this purpose is povidone, pVP. Contrary to other polymeric materials, the synthesis of povidone nanoparticles can take place under various condition, due to good solubility of this polymer in several organic and inorganic solvents. Moreover, povidone is known as nontoxic, non-carcinogenic, and temperature-insensitive substance. Its flexible design and the presence of various functional groups allow connection with the hydrophobic and hydrophilic drugs. It is worth noting, that pVP is regarded as an ecofriendly substance. Despite wide application of pVP in medicine, it was not often selected for the production of drug carriers. This review article is focused on recent reports on the role povidone can play in micro- and nano drug delivery systems. Advantages and possible threats resulting from the use of povidone are indicated. Moreover, popular biomedical aspects are discussed.

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“…After that, we assessed the effect of different stabilizers with different ratios by adding 0.5% and 1%w/v of PVP and PEG to DI-H2O before adding the curcumin solution.Finally, the nanosuspensions werefreeze-dried by (BachiLyovapor L-200,Switzerland) [17].…”

Section: Preparation Of Curcumin Nanoparticlesmentioning

confidence: 99%

“…Fourier transforms infrared spectroscopy (FTIR)analysis of curcumin, stabilizer, and nanocurcumin was performed using an FTIR spectrometer (PerkinElmer Inc, Shelton, CT, USA).A spectrum for each sample was recorded within therange of 4000-500 cm -1 [17].…”

Section: Characterization Of Curcumin Nanoparticlesmentioning

confidence: 99%

Biocompatible Luminescent Nanosized Curcumin: Verified Parameters Affecting Stability and Bioavailability

Mohamed¹

2020

IJDOS

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Purpose: Curcumin one of the herbal compounds that are used as an antitumor, antioxidant, and anti-inflammatory agent. However, curcumin applications are limited due to its poor chemical stability and low water-solubility. On the contrary, the enhanced solubility of nanocurcumin improves its bioavailability and cellular uptake. The present study aims to verify a simple, achievable, and reproducible method for preparation of biocompatible nanocurcumin and to optimize the different parameters included in this method. Methods: In our study, we used solvent anti-solvent precipitation method to synthesis curcumin nanoparticles. For biocompatibility, we screened different organic solvents to verify the best safe one with the highest solubility effect to curcumin. Furthermore, we tested the effect of adding stabilizersto enhance the stability and yielding capacity of the nanocurcumin. Thereafter, the stabilized nanosample was tested for water-solubility and luminescence. Results: Acetone-dissolved nanocurcumin gave clear amber yellow nanosuspension without any precipitate and with an acceptable concentration of nanosuspension. With limiting the stirring rate and time to the minimum, the nanosample was monodispersed. Furthermore, stabilized nanocurcumin revealed the highest solubility and luminescence. Conclusion:The prompt fluorescent property of the soluble nanosized curcumin would qualify this herbal nano-candidate to be utilized as a theranostic agent.

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Effect of high pressure homogenization on physicochemical properties of curcumin nanoparticles prepared by antisolvent crystallization using HPMC or PVP

Abstract: (2018) Effect of high pressure homogenization on physicochemical properties of curcumin nanoparticles prepared by antisolvent crystallization using HPMC or PVP. Materials Science and Engineering: C.

Cited by 23 publications

References 42 publications

Isoliquiritigenin Nanosuspension Enhances Cytostatic Effects in A549 Lung Cancer Cells

Isoliquiritigenin Nanosuspension Enhances Cytostatic Effects in A549 Lung Cancer Cells

Activity of Povidone in Recent Biomedical Applications with Emphasis on Micro- and Nano Drug Delivery Systems

Biocompatible Luminescent Nanosized Curcumin: Verified Parameters Affecting Stability and Bioavailability

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