Activity of Povidone in Recent Biomedical Applications with Emphasis on Micro- and Nano Drug Delivery Systems

Abstract

Due to the unwanted toxic properties of some drugs, new efficient methods of protection of the organisms against that toxicity are required. New materials are synthesized to effectively disseminate the active substance without affecting the healthy cells. Thus far, a number of polymers have been applied to build novel drug delivery systems. One of interesting polymers for this purpose is povidone, pVP. Contrary to other polymeric materials, the synthesis of povidone nanoparticles can take place under various condition, due to good solubility of this polymer in several organic and inorganic solvents. Moreover, povidone is known as nontoxic, non-carcinogenic, and temperature-insensitive substance. Its flexible design and the presence of various functional groups allow connection with the hydrophobic and hydrophilic drugs. It is worth noting, that pVP is regarded as an ecofriendly substance. Despite wide application of pVP in medicine, it was not often selected for the production of drug carriers. This review article is focused on recent reports on the role povidone can play in micro- and nano drug delivery systems. Advantages and possible threats resulting from the use of povidone are indicated. Moreover, popular biomedical aspects are discussed.

Amphiphilic Poly(N-vinylpyrrolidone) Nanoparticles Conjugated with DR5-Specific Antitumor Cytokine DR5-B for Targeted Delivery to Cancer Cells

“…Polymers based on N-vinylpyrrolidone derivatives are widely used in various medical devices and preparations, including the blood-retina nanocarrier platforms [33] and bioprinting [34]. PVP is used in drug delivery systems as a coating ingredient or in nanocarriers for the delivery of low-molecular-weight and hydrophobic drugs [8,35]. PVP is well-suited for bioconjugation as a drug carrier with a narrow molecular weight distribution [36].…”

“…A number or polymeric micelles with active tumor-targeting properties were proposed for drug delivery, for example, c(RGDyK)-linked poly(carboxybetaine methacrylate)-poly(crcaprolactone)-based [ 5 ], cRGD-conjugated poly(ethylene glycol)- b -poly( l -glutamic acid)-based [ 6 ], citric acid-functionalized poly(ε-caprolactone)-based micelles [ 7 ]. Poly( N -vinylpyrrolidone) is non-toxic, non-carcinogenic, eco-friendly, FDA-approved biocompatible water-soluble polymer with a rather long history of pharmaceutical use [ 8 ]. Amphiphilic poly( N -vinylpyrrolidone) derivatives (Amph-PVP) self-aggregate in aqueous solutions with the formation of micellar nanoscaled structures, which are capable to entrap various therapeutic molecules under mild conditions [ 9 ].…”

Toxicity Evaluation and Controlled-Release of Curcumin-Loaded Amphiphilic Poly-N-vinylpyrrolidone Nanoparticles: In Vitro and In Vivo Models

“…In the last decade, interest has arisen in carriers based on poly(N-vinylpyrrolidone) (PVP) [ 11 , 12 ]. Like PEG, PVP has a very long history of medical use [ 13 , 14 ].…”

One-Pot and Green Preparation of Phyllanthus emblica Extract/Silver Nanoparticles/Polyvinylpyrrolidone Spray-On Dressing

“…As it is non-toxic and biocompatible, PVP is used extensively in the pharmaceutical and biomedical industries [ 33 ]. It has been employed in the development of a variety of drug delivery systems, including oral, ophthalmic, topical, and transdermal delivery in a variety of formats, such as particles, hydrogels, and fibers [ 32 , 34 ]. PVP can also be used to create clear, thin, and well-distributed films [ 6 ].…”