Effect of high levels of Cu supplement on growth performance, rumen fermentation, and immune responses in goat kids

Solaiman, S. G.; Craig, Tom; Reddy, Gopal; Shoemaker, C.E.

doi:10.1016/j.smallrumres.2005.12.017

Cited by 31 publications

(24 citation statements)

References 18 publications

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“…In accordance with present study, Solaiman et al (2007) reported higher lymphocyte proliferation (P< 0.05) in kids supplemented with 100 mg Cu /day on day 98 of experimental period and Bartoskewitz et al (2007) reported higher (P<0.05) lymphocyte proliferative response in Cu supplemented young deer against ConA. In contrast, Ward et al (1997) reported that when 10 mg Cu/kg DM from CuSO 4 was added to a diet containing 4.5 mg Cu/kg DM and fed to two year old pregnant heifers, Cu supplementation produced a lower skin swelling response to PHA.…”

Section: Immune Responsesupporting

confidence: 93%

“…Moreover, much higher dietary supplementation levels up to 30 ppm of Cu did not cause any observable toxicity in Ewes (Eckert et al 1999). Effect of Cu on immune response in cattle and other species are well documented (Spears 2000;Dorton et al 2003;Bartoskewitz et al 2007 andSolaiman et al 2007). But the information regarding the influence of copper on enzyme activity and immune response in sheep is sparse, in spite of their economic importance.…”

Section: Introductionmentioning

confidence: 90%

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Effect of different level and source of copper supplementation on immune response and copper dependent enzyme activity in lambs

Senthilkumar

Nagalakshmi

Reddy

et al. 2008

Trop Anim Health Prod

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An experiment was conducted on 30 male Nellore lambs with average body weight (BW) of 15.45 +/- 0.06 kg to determine the level of the copper (Cu) supplementation in diet from inorganic and organic sources required for optimum immunity and its effect on copper dependent enzymes by allotting them randomly to five groups in completely randomized design. The dietary treatments were viz., basal diet (no Cu supplementation, BD), other four groups were offered BD supplemented with 7 or 14 ppm Cu from copper sulphate (CuSO(4)) and Cu-proteinate, respectively. The lambs were fed the respective diets at 3.5 per cent BW to meet the requirements except Cu for 180 days. The humoral immune response against Brucella abortus and chicken RBC was assessed after 90 days of feeding. The in vivo delayed type hyper sensitivity reaction against PHA-P and in vitro lymphocyte proliferation against Con A indicative of cell mediated immune response (CMI) was assayed at 180 days of feeding. At the end of experiment four lambs from each group were slaughtered for estimation of liver superoxide dismutase activity (SOD). The ceruloplasmin and RBC-SOD activities were higher (P < 0.05) in 14 ppm Cu supplemented lambs from Cu-proteinate at 90 and 180 days, while the liver SOD activity was higher (P < 0.05) in lambs fed 14 ppm Cu from CuSO(4). The STAT titres against B. abortus were higher in Cu supplemented lambs, with no effect of dose of supplementation. Lambs supplemented with Cu-proteinate had higher titers than CuSO(4) on 7 and 14 days of post sensitization. The total immunoglobulin concentration and the CMI response against PHA-P and Con-A was higher (P < 0.05) in lambs fed 14 ppm Cu-proteinae diet. The IgM level was though high in Cu supplemented lambs, no dose or source effect were observed. The study indicated that Cu dependent enzymes activity and immune response were highest and respond better against stress in lambs on 14 ppm supplemented Cu from Cu-proteinate.

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Section: Immune Responsesupporting

confidence: 93%

Section: Introductionmentioning

confidence: 90%

Effect of different level and source of copper supplementation on immune response and copper dependent enzyme activity in lambs

Senthilkumar

Nagalakshmi

Reddy

et al. 2008

Trop Anim Health Prod

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“…The positive effect of Cu supplementation on weight gains in kids (Solaiman et al, 2007) was confirmed also in our study. In kids of both experimental groups increased body weight gains were observed compared to control group in which they were the lowest.…”

Section: Discussionsupporting

confidence: 90%

“…Copper (Cu) is an essential component of several enzymes called cupro-enzymes (Cummins et al, 2008), and participates in the hemoglobin synthesis. The positive effect of Cu supplementation on weight gains and immunity in kids was described by Solaiman et al (2007). Copper also has an important role in fat metabolism (Engle et al, 2000;Datta et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Copper metabolism in goat-kid relationship at supplementation of inorganic and organic forms of copper

Páleníková¹,

Hauptmanová²,

Pitropovská³

et al. 2014

CZECH J ANIM SCI

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AbstrACt:The aim of the experiment was to compare the effect of inorganic and organic forms of copper (Cu) supplementation on Cu status of goats and their kids, colostrum and milk composition and quality, and on the Cu concentrations in amniotic fluids and fetal membranes. The experiment involved 22 clinically healthy pregnant goats with similar mean Cu concentration in blood serum. Goats were divided into 3 groups: E1, E2, and C. Basal feed ration differed only in Cu form and concentration in a grain mixture. The goats of experimental groups E1 and E2 received the supplement of Cu sulfate and Cu chelate, respectively. Control group C was without Cu supplementation. Blood samples from goats and kids were collected on the day of parturition (day 0; in kids before colostrum intake) and on days 2, 7, and 21 postpartum. On the same days the kids were weighed. Colostrum or milk samples were collected on days 0, 5, and 30. During delivery, also samples of amniotic fluids and fetal membranes were collected. Both forms of Cu supplementation resulted in higher average concentration of Cu (compared to control group) in blood serum of goats (19.5 ± 1.7 and 18.5 ± 2.5 vs. 15.2 ± 4.4 µmol/l, respectively) and blood serum of kids (6.7 ± 0.8 and 6.0 ± 0.5 vs. 6.0 ± 1.0 µmol/l, respectively). Significant differences in Cu serum concentration on the day of parturition in goats were observed in group E1 compared to control (P < 0.05) and also in kids of group E1 compared to group E2 and control (P < 0.05). The Cu concentration in the blood of kids on the day of parturition was significantly (P < 0.01) lower compared to that in maternal blood. Percentages of Cu concentration in the blood of kids in groups E1, E2, and C were 34, 33, and 39% of that in maternal blood. The results of Cu concentration in blood serum of goats on days 2, 7, and 21 were without significant differences between groups. Significantly higher Cu serum concentrations (P < 0.05) were observed in kids on day 2 in group E1 compared to control group and also on day 21 in group E1 compared to group E2. Colostrum Cu concentration was significantly (P < 0.05) higher in group E1 (10.6 ± 3.3 µmol/l) compared to group E2 (7.1 ± 1.5 µmol/l). There were no significant differences observed in Cu concentration in amniotic fluids and fetal membranes. The kids on both forms of Cu supplementation (on day 0 in group E1 and on days 2, 7, and 21 in group E2) had significantly (P < 0.05) higher average weight than the kids from control group. Our results are suggesting that the inorganic form of Cu (copper sulfate) is more efficient than organic (copper chelate) in influencing the Cu metabolism in goat-kid relationship and that Cu supplementing has a positive effect on the weight of kids.

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“…The phagocytic ability of neutrophils was increased when Cu was administered to Cu deficient goat kids. Dietary copper deficiency increases the accumulation of circulating neutrophils in the lung microcirculation (Solaiman et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Hematology and blood microelements of sheep in south Bohemia

Šoch¹,

Brouček

Srejberova³

2010

Biologia

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The efficiency of sheep is dependent on their health and well-being. The blood markers can be critical for improving of the physiological, nutritional and pathological status of sheep organism. The aim of this study was to test the hypotheses that the red and white blood cells and copper (Cu) and zinc (Zn) plasma contents are impacted by altitude and season. The ewes were kept at three farms. Blood samples were divided according to factors of altitude (550 m Spring values of haemoglobin and haematocrit were lower than fall values. The highest count of leucocytes was recorded at the altitude 950 m (9.57 G L −1 ), higher counts were contained in spring (P < 0.001). The lowest percentage of eosinophiles was found at the altitude of 800 m (5.81%) and the highest at the altitude of 550 m (9.26%) (P < 0.01). Phagocytose activities were the highest at the altitude of 950 m (95.07%) and the lowest at the altitude of 550 m (85.04%) (P < 0.001). Phagocytose activities were higher in fall than in spring. The highest Cu concentration was found at the altitude of 550 m and the lowest at the altitude of 800 m (17.04 µmol L −1 vs. 14.37 µmol L −1 ). Zn levels were higher at altitudes of 950 m and 800 m than at the altitude of 550 m (17.81 µmol L −1 , 17.00 µmol L −1 vs. 14.77 µmol L −1 ). We concluded that hematological markers and trace mineral content in grazed sheep may be impacted by altitude and season.

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Effect of high levels of Cu supplement on growth performance, rumen fermentation, and immune responses in goat kids

Cited by 31 publications

References 18 publications

Effect of different level and source of copper supplementation on immune response and copper dependent enzyme activity in lambs

Effect of different level and source of copper supplementation on immune response and copper dependent enzyme activity in lambs

Copper metabolism in goat-kid relationship at supplementation of inorganic and organic forms of copper

Hematology and blood microelements of sheep in south Bohemia

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