Effect of high-intensity focused ultrasound on sexual function in the treatment of uterine fibroids: comparison to conventional myomectomy

Wang, Xiaoyan; Qin, Juan; Wang, Lifang; Chen, Jin-Yun; Chen, Wenzhi; Tang, Liangdan

doi:10.1007/s00404-013-2775-2

Cited by 29 publications

(27 citation statements)

References 24 publications

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“…There was a report on the effect of USgHIFU on the sexual function for the treatment of uterine fibroids compared to conventional myomectomy [9]. In that article, an improvement of sexual function was observed after both HIFU and conventional myomectomy.…”

Section: Discussionmentioning

confidence: 93%

“…HIFU is the latest developed local ablation technique and a non-invasive technique for the treatment of uterine fibroid and adenomyosis. Results from several published reports have shown that USgHIFU ablation is a safe and feasible alternative for the treatment of uterine fibroids [1][2][3] and adenomyosis [4][5][6]. One advantage of HIFU is its non-invasiveness, which is associated with very low morbidity and very rapid recovery, with return to normal activity in 1 day.…”

Section: Introductionmentioning

confidence: 96%

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Ultrasound-guided high-intensity focused ultrasound treatment for uterine fibroid & adenomyosis: A single center experience from the Republic of Korea

Lee

Hong

Park

et al. 2015

Ultrasonics Sonochemistry

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We conclude that USgHIFU treatment for uterine fibroid and adenomyosis is an effective non-invasive therapy via the assessment of fibroid volume reduction, symptom improvement, UFS-QOL score increase, and acceptable level of side effects. Although preliminary experience of HIFU is encouraging, well-designed prospective trials and more clinical experiences are needed to ascertain the efficacy and safety of this new treatment.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 96%

Ultrasound-guided high-intensity focused ultrasound treatment for uterine fibroid & adenomyosis: A single center experience from the Republic of Korea

Lee

Hong

Park

et al. 2015

Ultrasonics Sonochemistry

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“…140 High-intensity focused ultrasound (HIFU) shrinks fibroids, facilitating recovery from anemia, depression, fatigue, and deep dyspareunia. 135 The performance of a hysterectomy has been associated with an increase in the postoperative FSFI and European Quality of Life Five-Dimension Scale scores in significant fashion compared with preoperative scores. 141 …”

Section: Benign Gynecologic Diseasementioning

confidence: 99%

Cancer, Benign Gynecology, and Sexual Function—Issues and Answers

Bennett

Incrocci

Baldwin

et al. 2016

The Journal of Sexual Medicine

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“…Most randomized controlled trials (RCTs) of fibroid therapies have been performed outside the United States (2–10), and those performed in the United States for the related problem of heavy menstrual bleeding have faced recruitment challenges (11–14). …”

Section: Introductionmentioning

confidence: 99%

Periprocedural outcomes comparing fibroid embolization and focused ultrasound: a randomized controlled trial and comprehensive cohort analysis

Barnard

Abdelmagied

Vaughan

et al. 2017

American Journal of Obstetrics and Gynecology

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Background Uterine fibroids are a common problem for reproductive-aged women, yet little comparative effectiveness research is available to guide treatment choice. Uterine artery embolization and magnetic resonance imaging–guided focused ultrasound surgery are minimally invasive therapies approved by the United States Food and Drug Administration for treating symptomatic uterine fibroids. The Fibroid Interventions: Reducing Symptoms Today and Tomorrow study is the first randomized controlled trial to compare these 2 fibroid treatments. (NCT00995878, clinicaltrials.gov) Objective To summarize treatment parameters and compare recovery trajectory and adverse events in the first 6 weeks after treatment. Study Design Premenopausal women with symptomatic uterine fibroids seen at 3 US academic medical centers were enrolled in the randomized controlled trial (n=57). Women meeting identical criteria who declined randomization but agreed to study participation were enrolled in a nonrandomized parallel cohort (n=34). The 2 treatment groups were analyzed by using a comprehensive cohort design. All women undergoing focused ultrasound and uterine artery embolization received the same postprocedure prescriptions, instructions, and symptom diaries for comparison of recovery in the first 6 weeks. Return to work and normal activities, medication use, symptoms, and adverse events were captured with postprocedure diaries. Data were analyzed using the Wilcoxon rank sum test or χ2 test. Multivariable regression was used to adjust for baseline pain levels and fibroid load when comparing opioid medication, adverse events, and recovery time between treatment groups because these factors varied at baseline between groups and could affect outcomes. Adverse events were also collected. Results Of 83 women in the comprehensive cohort design who underwent treatment, 75 completed postprocedure diaries. Focused ultrasound surgery was a longer procedure than embolization (mean [SD], 405 [146] vs 139 [44] min; P<.001). Of women undergoing focused ultrasound (n=43), 23 (53%) underwent 2 treatment days. Immediate self-rated postprocedure pain was higher after uterine artery embolization than focused ultrasound (median [interquartile range], 5 [1–7] vs 1 [1–4]; P=.002). Compared with those having focused ultrasound (n=39), women undergoing embolization (n=36) were more likely to use outpatient opioid (75% vs 21%; P<.001) and nonsteroidal anti-inflammatory medications (97% vs 67%; P<.001) and to have a longer median (interquartile range) recovery time (days off work, 8 [6–14] vs 4 [2–7]; P<.001; days until returned to normal, 15 [10–29] vs 10 [10–15]; P=.02). There were no significant differences in the incidence or severity of adverse events between treatment arms; 86% (42/49) of adverse events required only observation or nominal treatment, and no events caused permanent sequelae or death. After adjustment for baseline pain and uterine fibroid load, uterine artery embolization was still significantly associated with higher opioid use and lon...

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Effect of high-intensity focused ultrasound on sexual function in the treatment of uterine fibroids: comparison to conventional myomectomy

Abstract: Sexual function improved on average to some degree after both HIFU and conventional myomectomy.

Cited by 29 publications

References 24 publications

Ultrasound-guided high-intensity focused ultrasound treatment for uterine fibroid & adenomyosis: A single center experience from the Republic of Korea

Ultrasound-guided high-intensity focused ultrasound treatment for uterine fibroid & adenomyosis: A single center experience from the Republic of Korea

Cancer, Benign Gynecology, and Sexual Function—Issues and Answers

Periprocedural outcomes comparing fibroid embolization and focused ultrasound: a randomized controlled trial and comprehensive cohort analysis

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