Effect of High-Frequency Repetitive Transcranial Magnetic Stimulation on Brain Excitability in Severely Brain-Injured Patients in Minimally Conscious or Vegetative State

Manganotti, Paolo; Formaggio, Emanuela; Storti, Silvia Francesca; Fiaschi, Antonio; Battistin, Leontino; Tonin, Paolo; Piccione, Francesco; Cavinato, Marianna

doi:10.1016/j.brs.2013.06.006

Cited by 69 publications

(65 citation statements)

References 57 publications

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“…More work is also needed before using this tool in routine clinical practice, such as developing compact TMS-EEG equipment and fast, standardized data analysis software. Repetitive TMS should also be investigated for therapeutic purposes as positive effects have been observed in a few UWS and MCS patients [63,64] as well as in patients suffering from aphasia [65], depression [66], tinnitus [67] or migraine [68]. The challenge in future years will also be to combine information coming from different neuroimaging techniques available (e.g., fMRI, TMS, EEG) in order to deepen our understanding of brain (dys)functions and to improve the process of diagnosis, as well as in improving the prognosis in this challenging population.…”

Section: Resultsmentioning

confidence: 99%

Assessing consciousness in coma and related states using transcranial magnetic stimulation combined with electroencephalography

Gosseries

Thibaut

Boly

et al. 2014

Annales Françaises d'Anesthésie et de Réanimation

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Section: Resultsmentioning

confidence: 99%

Assessing consciousness in coma and related states using transcranial magnetic stimulation combined with electroencephalography

Gosseries

Thibaut

Boly

et al. 2014

Annales Françaises d'Anesthésie et de Réanimation

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“…Further studies are necessary to either confirm or refute this hypothesis. However, it is interesting to note that some researchers try to use rTMS in patients with brain injuries and altered states of consciousness, such as a persistent vegetative state or a minimally conscious state (Louise-Bender Pape et al, 2009; Manganotti et al, 2013; Guerra et al, 2014). There are both positive and negative results reported in these articles.…”

Section: Non-classical Effects Of Tms Related To Biophysical Effects mentioning

confidence: 99%

Possible Mechanisms Underlying the Therapeutic Effects of Transcranial Magnetic Stimulation

Chervyakov

Chernyavsky

Синицын

et al. 2015

Front. Hum. Neurosci.

271

169

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Transcranial magnetic stimulation (TMS) is an effective method used to diagnose and treat many neurological disorders. Although repetitive TMS (rTMS) has been used to treat a variety of serious pathological conditions including stroke, depression, Parkinson’s disease, epilepsy, pain, and migraines, the pathophysiological mechanisms underlying the effects of long-term TMS remain unclear. In the present review, the effects of rTMS on neurotransmitters and synaptic plasticity are described, including the classic interpretations of TMS effects on synaptic plasticity via long-term potentiation and long-term depression. We also discuss the effects of rTMS on the genetic apparatus of neurons, glial cells, and the prevention of neuronal death. The neurotrophic effects of rTMS on dendritic growth and sprouting and neurotrophic factors are described, including change in brain-derived neurotrophic factor concentration under the influence of rTMS. Also, non-classical effects of TMS related to biophysical effects of magnetic fields are described, including the quantum effects, the magnetic spin effects, genetic magnetoreception, the macromolecular effects of TMS, and the electromagnetic theory of consciousness. Finally, we discuss possible interpretations of TMS effects according to dynamical systems theory. Evidence suggests that a rTMS-induced magnetic field should be considered a separate physical factor that can be impactful at the subatomic level and that rTMS is capable of significantly altering the reactivity of molecules (radicals). It is thought that these factors underlie the therapeutic benefits of therapy with TMS. Future research on these mechanisms will be instrumental to the development of more powerful and reliable TMS treatment protocols.

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“…Although long-lasting autonomic effects of rTMS are substantially lacking, there is evidence that rTMS may alter HR during its application: stimulation of M1 induced a short-lasting increase of HR and blood pressure [126,127]; even in vegetative state patients, high-frequency rTMS can transiently increase HR [128], suggesting that rTMS of M1 may modulate the autonomic outflow in the absence of motor responses (and unspecific arousal). Low-frequency repetitive TMS, particularly after stimulation of the right hemisphere, induced a slight increase in the parasympathetic drive (i.e.…”

Section: Repetitive Transcranial Magnetic Stimulationmentioning

confidence: 99%

Nonlinear effects of respiration on the crosstalk between cardiovascular and cerebrovascular control systems

Bari

Marchi

Maria

et al. 2016

Phil. Trans. R. Soc. A.

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Cardiovascular and cerebrovascular regulatory systems are vital control mechanisms responsible for guaranteeing homeostasis and are affected by respiration. This work proposes the investigation of cardiovascular and cerebrovascular control systems and the nonlinear influences of respiration on both regulations through joint symbolic analysis (JSA), conditioned or unconditioned on respiration. Interactions between cardiovascular and cerebrovascular regulatory systems were evaluated as well by performing correlation analysis between JSA indexes describing the two control systems. Heart period, systolic and mean arterial pressure, mean cerebral blood flow velocity and respiration were acquired on a beat-to-beat basis in 13 subjects experiencing recurrent syncope episodes (SYNC) and 13 healthy individuals (non-SYNC) in supine resting condition and during head-up tilt test at 60° (TILT). Results showed that JSA distinguished conditions and groups, whereas time domain parameters detected only the effect of TILT. Respiration affected cardiovascular and cerebrovascular regulatory systems in a nonlinear way and was able to modulate the interactions between the two control systems with different outcome in non-SYNC and SYNC groups, thus suggesting that the analysis of the impact of respiration on cardiovascular and cerebrovascular regulatory systems might improve our understanding of the mechanisms underpinning the development of postural-related syncope.

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Effect of High-Frequency Repetitive Transcranial Magnetic Stimulation on Brain Excitability in Severely Brain-Injured Patients in Minimally Conscious or Vegetative State

Cited by 69 publications

References 57 publications

Assessing consciousness in coma and related states using transcranial magnetic stimulation combined with electroencephalography

Assessing consciousness in coma and related states using transcranial magnetic stimulation combined with electroencephalography

Possible Mechanisms Underlying the Therapeutic Effects of Transcranial Magnetic Stimulation

Nonlinear effects of respiration on the crosstalk between cardiovascular and cerebrovascular control systems

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