Assessing consciousness in coma and related states using transcranial magnetic stimulation combined with electroencephalography

Gosseries, Olivia; Thibaut, Aurore; Boly, Mélanie; Rosanova, Mario; Massimini, Marcello; Laureys, Steven

doi:10.1016/j.annfar.2013.11.002

Cited by 52 publications

(42 citation statements)

References 63 publications

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“…A growing number of studies have shown changes in brain functional connectivity (using resting-state functional magnetic resonance imaging [fMRI], as well as [high density] electroencephalography [EEG] combined with transcranial magnetic stimulation) and brain metabolism (using 18 F-fluorodeoxyglucose positron emission tomography [FDG-PET]) during states of altered consciousness (Gosseries et al, 2014;Guldenmund et al, 2012a). With resting-state fMRI, emphasis has been on analysis of separate resting-state networks (RSNs) (Damoiseaux et al, 2006) and particularly the default mode network (DMN).…”

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confidence: 99%

Propofol-Induced Frontal Cortex Disconnection: A Study of Resting-State Networks, Total Brain Connectivity, and Mean BOLD Signal Oscillation Frequencies

et al. 2016

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Propofol is one of the most commonly used anesthetics in the world, but much remains unknown about the mechanisms by which it induces loss of consciousness. In this resting-state functional magnetic resonance imaging study, we examined qualitative and quantitative changes of resting-state networks (RSNs), total brain connectivity, and mean oscillation frequencies of the regional blood oxygenation level-dependent (BOLD) signal, associated with propofol-induced mild sedation and loss of responsiveness in healthy subjects. We found that detectability of RSNs diminished significantly with loss of responsiveness, and total brain connectivity decreased strongly in the frontal cortex, which was associated with increased mean oscillation frequencies of the BOLD signal. Our results suggest a pivotal role of the frontal cortex in propofol-induced loss of responsiveness.

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confidence: 99%

Propofol-Induced Frontal Cortex Disconnection: A Study of Resting-State Networks, Total Brain Connectivity, and Mean BOLD Signal Oscillation Frequencies

et al. 2016

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“…limb position [46]. Reliance on behavioral measures (externally observable signs of consciousness and cognition) in communication with DoC patients seems be too prone to errors since it is influenced by motor, sensory and cognitive deficits of the patient [47,48]. Detecting awareness, assessing cognition, and interpretation of command-response activity requires more complicated and exact procedures.…”

Section: Approaches To Communication Disorders In Docmentioning

confidence: 99%

Komunikacja w grupie pacjentów z zaburzeniami świadomości – wnioskiz projektu InteRDoCTor

Komendziński

Mikołajewska

Mikołajewski

et al. 2017

MBS

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S u m m a r yThanks to recent advances in health care an increased number of patients may recover from severe brain injuries, but some of them are still assessed as non-responsive. Reliance on behavioural measures in communication with DoC patients seems be too prone to errors. There is need for solutions providing more objective attempts of bidirectional communication (intentional questions/commands and adequate related responses) in patients with DoC using significant processed by the patient stimuli and novel technologies (EEG-, fMRI-, BCI-based, etc.) based on recent scientific and clinical evidences. Such communication may be fulfilled even in the absence of behavior.This article aims at assessment the extent to which current possibilities in the area of devices for extended communication has been exploited, including own experiences within InteRDoCTor project. S t r e s z c z e n i e Dzięki najnowszym osiągnięciom w opiece zdrowotnej coraz większa liczba pacjentów może powrócić do zdrowia z poważnych urazów mózgu, lecz część z nich jest ciągle diagnozowana jako niereagujący na bodźce. Poleganie jedynie na miarach behawioralnych w komunikacji z pacjentami z zaburzeniami świadomości wydaje się zbyt podatne na błędy. Istnieje zapotrzebowanie na rozwiązania zapewniające bardziej obiektywne próby komunikacji dwukierunkowej (celowe pytania/polecenia i odpowiadające im reakcje)u pacjentów z zaburzeniami świadomości, z wykorzystaniem bodźców znaczących dla pacjenta i przetwarzanych przez niego oraz nowych technologii (opartych na EEG, fMRI, BCI, itd.) w oparciu o najnowsze dowody naukowe i kliniczne. Ww. komunikacja może być realizowana nawet w przypadku braku obserwowalnych zmian zachowania pacjenta.Artykuł ma na celu ocenę, w jakim zakresie wykorzystuje się możliwości w tym obszarze, w tym w oparciu o doświadczenia własne z projektu InteRDoCTor.

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“…For example, Nikulin et al [9] showed that the N100-component of the TMS-evoked response in the motor cortex is attenuated when the cortex is involved in the preparation of voluntary muscle movement. Futhermore, it found that connectivity is drastically weakened in lowered states of consciousness such as deep sleep [5] or coma [11][12]. More recently, progress has been made in developing TMS-EEG for diagnostic purposes, in particular in the case of epilepsy [13].…”

Section: Tms-eegmentioning

confidence: 99%

Dealing with artifacts in TMS-evoked EEG

Ilmoniemi

Hernandez-Pavon

Mäkelä

et al. 2015

2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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Assessing consciousness in coma and related states using transcranial magnetic stimulation combined with electroencephalography

Cited by 52 publications

References 63 publications

Propofol-Induced Frontal Cortex Disconnection: A Study of Resting-State Networks, Total Brain Connectivity, and Mean BOLD Signal Oscillation Frequencies

Propofol-Induced Frontal Cortex Disconnection: A Study of Resting-State Networks, Total Brain Connectivity, and Mean BOLD Signal Oscillation Frequencies

Komunikacja w grupie pacjentów z zaburzeniami świadomości – wnioskiz projektu InteRDoCTor

Dealing with artifacts in TMS-evoked EEG

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