Effect of high‐frequency near‐infrared diode laser irradiation on periodontal tissues during experimental tooth movement in rats

Gunji, Hidemi; Kunimatsu, Ryo; Tsuka, Yuji; Yoshimi, Yuki; Sumi, Keisuke; Awada, Tetsuya; Nakajima, Kengo; Kimura, Aya Hirata; Hiraki, Tomoka; Hirose, Naoto; Yanoshita, Makoto; Tanimoto, Kotaro

doi:10.1002/lsm.22797

Cited by 18 publications

(8 citation statements)

References 41 publications

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“…High-frequency near-infrared diode laser irradiation enhanced the proliferation and migration of human gingival epithelial cells [41] and mouse calvarial osteoblasts [42]; promoted epithelialization and bone formation in tooth extraction sockets, possibly by activating cell proliferation and differentiation in vivo [43]; and reduced temporomandibular joint pain [44,45]. Moreover, high-frequency near-infrared diode laser irradiation of periodontal tissue leads to metabolic activation, thereby increasing the tooth movement rate in rats [46]. Thus, high-frequency near-infrared diode laser irradiation may affect chondrocyte metabolism.…”

Section: Introductionmentioning

confidence: 99%

High-Frequency Near-Infrared Diode Laser Irradiation Attenuates IL-1β-Induced Expression of Inflammatory Cytokines and Matrix Metalloproteinases in Human Primary Chondrocytes

Sakata

Kunimatsu

Tsuka

et al. 2020

JCM

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High-frequency near-infrared diode laser provides a high-peak output, low-heat accumulation, and efficient biostimulation. Although these characteristics are considered suitable for osteoarthritis (OA) treatment, the effect of high-frequency near-infrared diode laser irradiation in in vitro or in vivo OA models has not yet been reported. Therefore, we aimed to assess the biological effects of high-frequency near-infrared diode laser irradiation on IL-1β-induced chondrocyte inflammation in an in vitro OA model. Normal Human Articular Chondrocyte-Knee (NHAC-Kn) cells were stimulated with human recombinant IL-1β and irradiated with a high-frequency near-infrared diode laser (910 nm, 4 or 8 J/cm2). The mRNA and protein expression of relevant inflammation- and cartilage destruction-related proteins was analyzed. Interleukin (IL) -1β treatment significantly increased the mRNA levels of IL-1β, IL-6, tumor necrosis factor (TNF) -α, matrix metalloproteinases (MMP) -1, MMP-3, and MMP-13. High-frequency near-infrared diode laser irradiation significantly reduced the IL-1β-induced expression of IL-1β, IL-6, TNF-α, MMP-1, and MMP-3. Similarly, high-frequency near-infrared diode laser irradiation decreased the IL-1β-induced increase in protein expression and secreted levels of MMP-1 and MMP-3. These results highlight the therapeutic potential of high-frequency near-infrared diode laser irradiation in OA.

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Section: Introductionmentioning

confidence: 99%

High-Frequency Near-Infrared Diode Laser Irradiation Attenuates IL-1β-Induced Expression of Inflammatory Cytokines and Matrix Metalloproteinases in Human Primary Chondrocytes

Sakata

Kunimatsu

Tsuka

et al. 2020

JCM

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“…The calcium pool would be triggered when the NIR acts on the ER, and ERK1/2 would then be activated. The phosphorylated ERK1/2 can transport into cell nucleus and interact with different kinds of transcription factors (such as AP1, ATF, EIK‐1, and NF‐kB), which finally promotes cell proliferation and migration on wound bed …”

Section: Resultsmentioning

confidence: 99%

Infrared Skin‐Like Active Stretchable Electronics Based on Organic–Inorganic Composite Structures for Promotion of Cutaneous Wound Healing

Zhang

Jiang

et al. 2019

Adv Materials Technologies

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Recent studies on flexible/stretchable medical electronics are almost all focusing on passive monitoring of physiological signs for medical diagnostics, but rare reports have been found on those for active therapeutic purposes. Here, a novel infrared skin‐like active stretchable electronics (ISASE) is introduced with the organic–inorganic composite design for promotion of cutaneous wound healing, which can be conformally mounted anywhere on the human body due to its excellent flexibility and stretchability. Comprehensive experiments, including the proliferation and migration of human skin fibroblasts and rat dermal fibroblasts in vitro, and various tests on wound healing of rats, show favorable effects of the ISASE on promoting the fibroblast migration and proliferation, reducing the inflammatory phase, stimulating the angiogenesis, and shorting the wound healing period. A typical ISASE significantly shortens the cure time for a wounded rat by at least two days compared with the normal treatment with 12 days cure. The mechanical tests confirm the validity of the ISASE when used in extreme large deformations (e.g., stretched by up to 80% strain), which enables the conformability with the human body. The present portable and wearable ISASE demonstrates great potential for cutaneous wound healing, which constitutes an important complement to the current applications in the healthcare field.

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“…Tooth movement during orthodontic therapy is usually associated with bone resorption on the pressure side and bone regeneration on the tension side 129 . Several strategies have been proposed to decrease the treatment time in orthodontic therapy.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, Gunji et al . 129 examined the effect of high frequency NIR diode laser irradiation with a wavelength of 910 nm on tooth movement. They reported that 910 nm NIR laser irradiation on periodontal tissue resulted in metabolic activation, which ultimately enhanced tooth movement during orthodontic treatment.…”

Section: Discussionmentioning

confidence: 99%

NIR light-assisted phototherapies for bone-related diseases and bone tissue regeneration: A systematic review

Wan¹,

Zhang²,

Lv³

et al. 2020

Theranostics

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Recently, the rapid development of biomaterials has induced great interest in the precisely targeted treatment of bone-related diseases, including bone cancers, infections, and inflammation. Realizing noninvasive therapeutic effects, as well as improving bone tissue regeneration, is essential for the success of bone‑related disease therapies. In recent years, researchers have focused on the development of stimuli-responsive strategies to treat bone-related diseases and to realize bone regeneration. Among the various external stimuli for targeted therapy, near infrared (NIR) light has attracted considerable interests due to its high tissue penetration capacity, minimal damage toward normal tissues, and easy remote control properties. The main objective of this systematic review was to reveal the current applications of NIR light-assisted phototherapy for bone-related disease treatment and bone tissue regeneration. Database collection was completed by June 1, 2020, and a total of 81 relevant studies were finally included. We outlined the various therapeutic applications of photothermal, photodynamic and photobiomodulation effects under NIR light irradiation for bone‑related disease treatment and bone regeneration, based on the retrieved literatures. In addition, the advantages and promising applications of NIR light-responsive drug delivery systems for spatiotemporal-controlled therapy were summarized. These findings have revealed that NIR light-assisted phototherapy plays an important role in bone-related disease treatment and bone tissue regeneration, with significant promise for further biomedical and clinical applications.

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Effect of high‐frequency near‐infrared diode laser irradiation on periodontal tissues during experimental tooth movement in rats

Abstract: This study demonstrates that high-frequency near-infrared diode laser irradiation of periodontal tissue leads to metabolic activation, which ultimately increases the rate of tooth movement. Lasers Surg. Med. © 2018 Wiley Periodicals, Inc.

Cited by 18 publications

References 41 publications

High-Frequency Near-Infrared Diode Laser Irradiation Attenuates IL-1β-Induced Expression of Inflammatory Cytokines and Matrix Metalloproteinases in Human Primary Chondrocytes

High-Frequency Near-Infrared Diode Laser Irradiation Attenuates IL-1β-Induced Expression of Inflammatory Cytokines and Matrix Metalloproteinases in Human Primary Chondrocytes

Infrared Skin‐Like Active Stretchable Electronics Based on Organic–Inorganic Composite Structures for Promotion of Cutaneous Wound Healing

NIR light-assisted phototherapies for bone-related diseases and bone tissue regeneration: A systematic review

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