Effect of high dietary intake of nickel in the West African dwarf goat - Provisional Communication

Yousuf, MB

doi:10.4314/gjas.v35i1.1855

Cited by 4 publications

(2 citation statements)

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“…The decrease in serum total protein and albumin of Cd-treated mice might be due to changes in protein synthesis and/or metabolism (Dostal et al, 1989;Das and Dasgupta, 2000). This result is in agreement with other findings (Yousuf, 2002). Cadmium is one of the heavy metals which induce membrane damage (Uyanik et al, 2001).…”

Section: Discussionsupporting

confidence: 86%

Combined protective effect of vitamins C and E on cadmium induced oxidative liver injury in rats

Layachi¹,

Kechrid²

2012

Afr. J. Biotechnol.

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Our study pertains to the potential ability of vitamin C and/or vitamin E, used as nutritional supplements, to alleviate oxidative stress induced by cadmium. Male rats were randomly divided into five groups of eight each. Group I served as the controls; group II received in their drinking water CdCl 2 (200 mg/L); group III received both CdCl 2 and vitamin C (1.5 g/L of water); group IV was treated with CdCl 2 and vitamin E (400 mg/kg diet); and group V received CdCl 2 + vitamin C + vitamin E. The exposure of rats to cadmium chloride for 30 days resulted in a significant decrease in body weight gain. Cadmium treatment also produced oxidative liver injury characterized by increasing serum glucose concentration, glutamate-pyruvate transaminase (GPT), alanine aminotransaminase (GOT) and alkaline phosphatase (ALP) activities. Meanwhile cadmium supplementation decreased serum total protein and albumin in animals. In addition, liver glutathione level, catalase and glutathione peroxidase (GSH-Px) activities were diminished. With vitamin C and vitamin E administration during intoxication of cadmium, corrective effects on Cd-induced oxidative stress in the liver was observed. In conclusion, this study demonstrates that oral exposure to Cd caused reduction in LPO and antioxidant enzyme activities in rat's liver, and vitamin C or vitamin E may have partial ameliorative effects on these disturbances, whereas vitamin C and vitamin E together assured a more efficient protection of the organ against the noticed oxidative stress.

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Section: Discussionsupporting

confidence: 86%

Combined protective effect of vitamins C and E on cadmium induced oxidative liver injury in rats

Layachi¹,

Kechrid²

2012

Afr. J. Biotechnol.

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“…The treatment with ZnO in rats led to a significant increase in serum creatinine, BUN, Bilirubin, and Phosphorus levels, and a significant decrease in glucose, HDL, TG, cholesterol, TP, and uric acid levels. A significant decrease in serum TP and albumin levels in exposed animals are related to the changes in protein synthesis and metabolism [23]. Zhu et al [24] studied toxic responses in oral administration for rat exposed to a mixture of five toxic elements, and found that the total cholesterol, HDL, and TG reduced in the high dose group compared to the control group.…”

Section: Discussionmentioning

confidence: 99%

Chronic Zinc Oxide Nanoparticles Exposure Produces Hepatic and Pancreatic Impairment in Female Rats

Hosseini

Amani

Moshrefi

et al. 2020

IJT

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Background: Zinc Oxide (ZnO) nanoparticles are used for various industrial and domestic purposes and its release into the environment leads to the adverse effects among humans. This study aimed to evaluate the effect of rat exposure to ZnO nanoparticles on the histopathology of the liver and pancreas tissues, and serum oxidative stress parameters. Methods: Eighty female adult Wistar rats were divided into eight experimental, control and sham groups. They received ZnO nanoparticles at 4, 8, 25, 50, 100, or 200 mg/kg, or normal saline intraperitoneally for 30 days twice a week. Then, the blood samples of the rats were collected by heart puncture for biochemical analyses, and then sacrificed. Finally, the liver and pancreas tissues were harvested for histopathological examinations. Results: Significant amounts of nanoparticles were accumulated in the liver and pancreas of the rats, causing tissue and cellular damages. The ZnO nanoparticles reduced the levels of serum triglyceride, glucose, cholesterol, albumin, and increased the bilirubin and liver enzymes, such as ALT, AST, ALP, amylase and lipase at high doses. In addition, the evidence of histopathological lesions, hyperemia, inflammatory cell infiltration, and necrosis were noted in the liver and pancreas tissue slides upon microscopic examinations. Finally, the body and liver weights decreased in the rat groups receiving ZnO nanoparticle dose dependently. Conclusion: ZnO nanoparticles had toxic effects on the liver and pancreas, leading to destructive tissue and cellular changes in the rats.

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Effect of Environmental and Occupational Exposures to Heavy Metals: The Health Implications

Anyanwu

Ezejiofor

Nwaogazie

et al. 2019

Day 2 Tue, August 06, 2019

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The craze for technological development has given rise to environmental safety concerns. Various human activities such as artisanal mining, illegal refining, use of leaded petrol, illegal disposal and burning of toxic waste, absorption of production industries in inhabited areas have led to high contamination and pollution associated with heavy metals. The research was done to explore the effect of low dose exposure to heavy metal mixture using male albino rats as experimental animals. The experimental rats were separated into two equal groups; (i) control receiving only deionized water, (ii) combination of metals (PbCl2+ CdCl2 + HgCl2). Treatment was carried out through oral gavage. Induced low dose heavy metal mixture substantially decreased the follicle stimulating hormone, luteinizing hormone and testosterone levels and significantly increased the prolactin level. It also resulted to hepatotoxicity by significantly increasing the liver enzymes and bilirubin level, thereby reducing the total protein and albumin levels. The lipid profile was also investigated to check the risk associated with the cardiovascular system. The result showed a considerable increase (P<0.05) in triglycerides, total cholesterol, low density lipoprotein and very low density lipoprotein and a significant reduction in high density lipoprotein when compared with the control group. Furthermore, low dose heavy metal mixture induced histopathological changes to the liver. Collectively, our findings clearly highlight that environmental and occupational exposure to heavy metals resulted to hepatotoxicity, risk to the cardiovascular system and changes to the hormonal system.

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Effect of high dietary intake of nickel in the West African dwarf goat - Provisional Communication

Cited by 4 publications

References 0 publications

Combined protective effect of vitamins C and E on cadmium induced oxidative liver injury in rats

Combined protective effect of vitamins C and E on cadmium induced oxidative liver injury in rats

Chronic Zinc Oxide Nanoparticles Exposure Produces Hepatic and Pancreatic Impairment in Female Rats

Effect of Environmental and Occupational Exposures to Heavy Metals: The Health Implications

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