2021
DOI: 10.1111/nmo.14225
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Effect of high altitude on human postprandial 13C‐octanoate metabolism, intermediary metabolites, gastrointestinal peptides, and visceral perception

Abstract: Objective: At high altitude (HA), acute mountain sickness (AMS) is accompanied by neurologic and upper gastrointestinal symptoms (UGS). The primary aim of this study was to test the hypothesis that delayed gastric emptying (GE), assessed by 13 C-octanoate breath testing (OBT), causes UGS in AMS. The secondary aim was to assess post-gastric mechanisms of OBT, which could confound results under these conditions, by determination of intermediary metabolites, gastrointestinal peptides, and basal metabolic rate.Met… Show more

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“…16 Neurologic and upper gastrointestinal symptoms like delayed gastric emptying are seen in AMS at high altitudes. 17 There is suppressed gastric motility and emptying due to changes in vagal activity which further results in gastric distension and sensation of satiety at high altitude; thus, an enthusiastic feeding may further aggravate nausea and vomiting which is commonly seen in AMS. In the present study, there were more cases of severe acid peptic activities in patients from the high altitude of Rasuwa compared to Kathmandu valley, with a comparatively higher percentage of ulcers, duodenal (7.7% vs. 7%), gastric (8.5% vs 5.6%) and esophageal (4.1% vs.…”
Section: Methodsmentioning
confidence: 99%
“…16 Neurologic and upper gastrointestinal symptoms like delayed gastric emptying are seen in AMS at high altitudes. 17 There is suppressed gastric motility and emptying due to changes in vagal activity which further results in gastric distension and sensation of satiety at high altitude; thus, an enthusiastic feeding may further aggravate nausea and vomiting which is commonly seen in AMS. In the present study, there were more cases of severe acid peptic activities in patients from the high altitude of Rasuwa compared to Kathmandu valley, with a comparatively higher percentage of ulcers, duodenal (7.7% vs. 7%), gastric (8.5% vs 5.6%) and esophageal (4.1% vs.…”
Section: Methodsmentioning
confidence: 99%