Effect of hesperidin in vitro on root dentine collagen and demineralization

Hiraishi, Noriko; Sono, Ryohei; Islam, Md. Sofiqul; Otsuki, Masayuki; Tagami, Junji; Takatsuka, Tsutomu

doi:10.1016/j.jdent.2011.03.002

Cited by 53 publications

(59 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, the TMR measurement showed that the incubation in CHX did not contribute to suppressed ΔZ. This finding was consistent with that of a previous study involving bovine root dentin 22) . The preserved organic matrix might hamper further diffusion of calcium and phosphate ions out of the dentinal lesion of caries, resisting further demineralization.…”

Section: Discussionsupporting

confidence: 93%

“…They have been the focus of several recent studies potential materials in the prevention of oral diseases, particularly plaquerelated diseases, such as dental caries [19][20][21] . A previous study using hesperidin (HPN), a citrus flavonoid, showed that HPN preserved bovine dentin collagen against proteolytic degradation 22) . It has also been reported that HPN reduced the susceptibility of dentin lesion to acid dependent demineralization with the potential to promote remineralization process 22) .…”

Section: Intorductionmentioning

confidence: 99%

“…A previous study using hesperidin (HPN), a citrus flavonoid, showed that HPN preserved bovine dentin collagen against proteolytic degradation 22) . It has also been reported that HPN reduced the susceptibility of dentin lesion to acid dependent demineralization with the potential to promote remineralization process 22) . In this study, we used human root dentin to confirm the effect of HPN to resist collagenous degradation and arrest demineralization.…”

Section: Intorductionmentioning

confidence: 99%

See 2 more Smart Citations

<I>In vitro</I> effect of hesperidin on root dentin collagen and de/re-mineralization

et al. 2012

View full text Add to dashboard Cite

The aims of this study were to investigate the effects of hesperidin, a citrus flavonoid, on human root dentin demineralization and collagen preservation, and compare it with chlorhexidine and grape seed extract. Specimens were assigned to different treatment groups: hesperidin, chlorhexidine and grape seed extract. Specimens were subjected to pH cycling by demineralization for 14 h, incubation in testing solutions for 2 h and remineralization in presence of bacterial-derived collagenase for 8 h, for 8 days. Calcium release was measured by means of an atomic absorption spectrophotometer, and degraded collagen matrix was investigated by hydroxyproline assay. Specimens were assessed longitudinally with transverse micro-radiography to investigate lesion depth and mineral loss. In hesperidin and grape seed extract groups, demineralization was reduced when the collagen matrix was preserved. The hesperidin group showed the lowest value in lesion depth and mineral loss, indicating that hesperidin inhibited demineralization and probably enhanced remineralization even under fluoride-free conditions.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Intorductionmentioning

confidence: 99%

Section: Intorductionmentioning

confidence: 99%

See 1 more Smart Citation

<I>In vitro</I> effect of hesperidin on root dentin collagen and de/re-mineralization

et al. 2012

View full text Add to dashboard Cite

show abstract

“…In addition, PA (6.5% w/w) was added to CPP-ACFP to prepare the CPP-ACFP+PA group. Each specimen was immersed in 37 o C demineralizing solution for 14 h, testing solutions or pastes for 2 h and remineralizing solution for 8 h following the protocol by Hiraishi et al 25 The CPP-ACP, CPP-ACFP and CPP-ACFP+PA pastes were applied directly to wet dentine surface using disposable brushes to form a thickness of 0.5 mm and the specimens were kept in 100% humidity in a 37 o C incubator. While the PA and F solutions with dentine specimens were kept at 37 o C incubator.…”

Section: Methods Of Ph Cyclingmentioning

confidence: 99%

Synergistic effect of proanthocyanidin and CPP-ACFP on remineralization of artificial root caries

2015

View full text Add to dashboard Cite

show abstract

“…It has also been reported that hesperidin reduced the susceptibility of dentine lesions to acid-dependent demineralization with the potential to promote the remineralization process [Hiraishi et al, 2011]. In another paper, hes- peridin was found to reduce lesion depth and mineral loss, indicating that hesperidin inhibited demineralization and probably enhanced remineralization even under fluoride-free conditions [Islam et al, 2012].…”

Section: Hesperidinmentioning

confidence: 92%

Natural Products and Caries Prevention

Cheng

et al. 2015

Caries Res

View full text Add to dashboard Cite

Dental caries is considered as the most common polymicrobial oral disease in the world. With the aim of developing alternative approaches to reduce or prevent the decay, numerous papers showed the potential anticaries activity of a number of natural products. The natural products with anticaries effects are selected from e.g. food, beverages, flowers or traditional herbs. Most of the effective components are proven to be polyphenol compounds. Many of the natural products are studied as antibacterial agents, while some of them are found to be effective in shifting the de-/remineralization balance. However, the mechanisms of the anticaries effects are still unclear for most of the natural products. In the future, more efforts need to be made to seek novel effective natural products via in vitro experiment, animal study and in situ investigations, as well as to enhance their anticaries effects with the help of novel technology like nanotechnology.

show abstract

Effect of hesperidin in vitro on root dentine collagen and demineralization

Cited by 53 publications

References 28 publications

<I>In vitro</I> effect of hesperidin on root dentin collagen and de/re-mineralization

<I>In vitro</I> effect of hesperidin on root dentin collagen and de/re-mineralization

Synergistic effect of proanthocyanidin and CPP-ACFP on remineralization of artificial root caries

Natural Products and Caries Prevention

Contact Info

Product

Resources

About