Effect of heparin surface modification in reducing silicone oil adherence to various intraocular lenses

Arthur, Stella N.; Peng, Qun; Apple, David J.; Escobar-Gómez, Marcela; Bianchi, Roberto; Pandey, Suresh K; Werner, Liliana

doi:10.1016/s0886-3350(01)00891-4

Cited by 26 publications

(30 citation statements)

References 33 publications

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“…33 This phenomenon might be explained by the fact that coating of PMMA IOLs with heparin converts their hydrophobic surface into a hydrophilic one. Studies from our laboratory 34,35 have reported that the interaction of silicone oil with a silicone IOL is dramatically decreased if the latter is surface modified with heparin ( Figure 2a and b). Its hydrophilic chains bound to the surface of the IOL extend into the aqueous media and form a highly hydrated layer around the lens by trapping water molecules.…”

Section: Silicone Oil Interaction With Different Iol Materialsmentioning

confidence: 98%

“…[30][31][32][33][34][35] Apple and associates 30,31,34,35 in three different studies have compared the degree of silicone oil adherence occurring with several IOLs fabricated from various biomaterials. These studies from our laboratory have demonstrated that the more hydrophobic materials with higher dispersive energy and relatively higher contact angles had more silicone oil adherence.…”

Section: Silicone Oil Interaction With Different Iol Materialsmentioning

confidence: 99%

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Post cataract-intraocular lens (IOL) surgery opacification

Trivedi

Werner

Apple

et al. 2002

Eye

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Intraocular lens (IOL) implantation has no doubt been one of the most satisfying advances of medicine. Millions of individuals with visual disability or frank blindness from cataracts had and continue to have benefit from this procedure. It has been reported by ophthalmologists that the modern cataract-intraocular lens (IOL) surgery is safe and complication-free most of the time. This makes the watchword for any cataract surgeon to be 'implantation,' 'implantation,' 'implantation.' In the mid1980s, as IOLs were evolving rapidly, the watchword of the implant surgeon was 'fixation,' 'fixation,' 'fixation.' Most techniques, lenses and surgical adjuncts now allow us to achieve the basic requirement for successful IOL implantation, namely longterm stable IOL fixation in the capsular bag.However despite this advancement some items 'slipped through cracks.' In this article, we would like to alert the reader to a new watchword, namely 'opacification,' 'opacification,' 'opacification.' Here we will be talking about the good, the bad, and the ugly. Examples of the 'good' include the recent successes now being achieved in reducing the incidence of posterior capsule opacification. Examples of the 'bad' include various proliferations of anterior capsule cells, problems caused by silicone oil adherence to IOLs and problems with piggyback IOLs. The 'ugly' include the sometimes striking and often visually disabling opacifications occurring on and within IOL optics, both on some modern foldable IOLs as well as a poly(methyl methacrylate) (PMMA) optic degradation occurring with some models a decade or more after implantation.

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Section: Silicone Oil Interaction With Different Iol Materialsmentioning

confidence: 98%

Section: Silicone Oil Interaction With Different Iol Materialsmentioning

confidence: 99%

Post cataract-intraocular lens (IOL) surgery opacification

Trivedi

Werner

Apple

et al. 2002

Eye

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“…Recently, Arthur et al [19]investigated the effect of heparin surface modification (HSM) and silicone oil (AdatoSil 5000, Escalon Ophthalmic) adherence to various IOLs. The mean silicone oil coverage of the hydrophilic acrylic IOLs (Centerflex 600H, Rayner) was 5.6 ± 2.5%; of the HSM PMMA IOLs (CeeOn 811) it was 6.2 ± 4.3%; of the HSM silicone optic IOLs (CeeOn Edge 911), 6.7 ± 3.2%, and of the standard PMMA IOLs (CeeOn Edge 809A), 20.3 ± 13.3%.…”

Section: Discussionmentioning

confidence: 99%

“…In several clinical and experimental studies, the interaction of silicone oil with various IOLs has been investigated [19, 20, 21, 22, 23]. In most of these studies, one type of silicone oil was used.…”

Section: Introductionmentioning

confidence: 99%

Interaction of Intraocular Lenses with Various Concentrations of Silicone Oil: An Experimental Study

Öner

Saatci²,

Sarıoğlu³

et al. 2003

Ophthalmologica

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The aim of this study was to evaluate the interaction between various widely used intraocular lenses (IOLs) and silicone oils of different viscosities. Four groups of IOLs, including monoblock foldable hydrophilic acrylic IOLs (Morcher, type 92s); monoblock hydrophobic acrylic IOLs (Acrysof^®-SA60AT, Alcon); single-piece rigid polymethylmethacrylate (PMMA) IOLs (Intraocular Optical International-IOI-65130) and a three-piece foldable silicone optic IOL (CeeOn^® Edge 911A, Pharmacia UpJohn) were analyzed in vitro to determine the percentage adherence 1,000-centistoke, 1,300-centistoke or 5,000-centistokes silicone oil on the IOL optic. For each IOL type, there was no statistically significant difference in the mean silicone oil coverage (MSC) of the IOL optics for the different viscosities of silicone oil. Silicone IOLs had the highest MSC percentage (79.9%) whereas hydrophilic acrylic IOLs were the least silicone-covered IOLs (7.8%) compared to the other IOL types tested in this study. It is not the concentration of silicone oil that affects silicone oil coverage. When performing small-incision cataract surgery in patients who may require silicone oil injection, foldable hydrophilic acrylic or hydrophobic acrylic lenses should be preferred over standard foldable silicone lenses.

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“…25 Optic diameter is also known to influence the formation of PCO, the incidence being lower in IOLs with larger optic diameter.…”

Section: 2324mentioning

confidence: 99%