Effect of heparin administration on urine protein excretion during the developmental stage of experimentally induced laminitis in horses

Uberti, Benjamín; Pressler, Barrak M.; Alkabes, Stephane B; Chang, Ching-Yun; Moore, George E.; Lescun, Timothy B.; Sojka, Janice E.

doi:10.2460/ajvr.71.12.1462

Cited by 8 publications

(3 citation statements)

References 30 publications

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“…Currently, low-molecular-weight heparin fractions (LMWHFs) are replacing UFH for therapeutic use in horses owing to a number of advantages, including a more predictable pharmacokinetic profile and equal antithrombotic properties, but resulting in fewer haemorrhagic episodes 21. The recommended dosage regimen for UFH is 80 iu/kg subcutaneously every eight hours 22. Therefore, an intravenous dose of 120 iu/kg was considered an excessive amount of UFH.…”

Section: Discussionmentioning

confidence: 99%

Accidental overdose of intravenously injected unfractionated heparin followed by prolonged clotting times in an anaesthetised Shetland pony

Pekkola¹,

Braun²,

Menzies³

2018

Vet Rec Case Rep

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A six-year-old Shetland pony stallion was presented for elective castration. During surgical preparations, undiluted heparin (120 iu/kg) was unintentionally used for intravenous catheter flushing instead of heparinised saline solution. Surgery was cancelled for that day. Thromboelastography was used to monitor blood coagulation immediately after the accidental heparin overdose and on the following days. Three days after the heparin overdose, the coagulation parameters had returned to normal values and the pony was castrated. Anaesthesia and surgery were uneventful without any signs of coagulopathy. One day after surgery, the pony started to show signs of colic and was further diagnosed with colitis, most likely unrelated to heparin but due to repeated administration of penicillin and anaesthesia. Despite intensive treatment, the pony deteriorated progressively and was euthanased due to poor prognosis. Drug overdose is an example of medication error and is one of the most common errors in medicine.

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Section: Discussionmentioning

confidence: 99%

Accidental overdose of intravenously injected unfractionated heparin followed by prolonged clotting times in an anaesthetised Shetland pony

Pekkola¹,

Braun²,

Menzies³

2018

Vet Rec Case Rep

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“…Heparin. Heparin therapy does not prevent the development of clinical or histopathologic signs of laminitis in experimental models of CHO-induced laminitis [3,8]. However, in studies using equine digital endothelium, both unfractionated heparin and low-molecular-weight heparin (LMWH) effectively inhibited neutrophil-derived myeloperoxidase production [9], suggesting a potential application for heparin in the prevention of SIRS-associated laminitis.…”

Section: Referencesmentioning

confidence: 99%

What's new in laminitis research? II: advances in laminitis treatment

Grenager

Orsini

2012

Journal of Equine Veterinary Science

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“…A recent report showed an apparent reduction in laminitis incidence after colic surgery in horses administered low molecular weight heparin however the control group in this study was historical and the total incidence of laminitis was low (de la Rebiere et al 2008). Additionally, other reports have shown no beneficial effect of heparin for laminitis prophylaxis (Belknap and Moore 1989;Uberti et al 2010). …”

Section: Laminitis Prophylaxismentioning

confidence: 72%

Drug delivery to equine digital lamellar tissue

Underwood¹

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Laminitis, a serious and debilitating disease of the equine foot, is a significant cause of wastage in the equine industry. There is no scientifically validated treatment and laminitis prophylaxis is currently limited to digital cryotherapy. Several key steps in laminitis pathophysiology have been elucidated, resulting in identification of drugs that may prevent laminitis (anti-laminitis drugs (ALDs)). Many of these pharmaceuticals are not suitable for systemic delivery but may be amenable to either local or nanoparticle delivery mechanisms.The aim of this thesis was to evaluate local, systemic and nanoparticle delivery mechanisms, using the matrix metalloproteinase (MMP) inhibitor marimastat, to establish a method of drug delivery that yields sustained therapeutic lamellar concentrations for experimental and potential clinical use. In order to establish marimastat concentrations necessary for inhibition of lamellar MMPs, zymography was performed using lamellar homogenates incubated in increasing concentrations of marimastat. Based on this assay, target marimastat concentrations of 177 ng/mL were set (the concentration necessary to inhibit 90% of lamellar MMP-2 and MMP-9).

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Effect of heparin administration on urine protein excretion during the developmental stage of experimentally induced laminitis in horses

Abstract: Urine protein excretion increased during the developmental stages of carbohydrate-induced laminitis in horses; administration of heparin prevented that increase, but did not delay onset or decrease severity of lameness.

Cited by 8 publications

References 30 publications

Accidental overdose of intravenously injected unfractionated heparin followed by prolonged clotting times in an anaesthetised Shetland pony

Accidental overdose of intravenously injected unfractionated heparin followed by prolonged clotting times in an anaesthetised Shetland pony

What's new in laminitis research? II: advances in laminitis treatment

Drug delivery to equine digital lamellar tissue

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