Effect of hemorrhagic hypotension on extracellular level of dopamine, cortical oxygen pressure and blood flow in brain of newborn piglets

Brain Oxygenation and Metabolism during Repetitive Apnea with Resuscitation of 21% and 100% Oxygen in Newborn Piglets

“…This ''selectively vulnerable'' dopaminergic region of the brain has been shown to be uniquely susceptible to recurrent hypoxic events. Our earlier studies showed that the dopaminergic system of the striatum of a newborn piglet's brain is very sensitive to the local oxygen pressure (6,(9)(10)(11). Therefore, resuscitation with 100% oxygen, by improving oxygen levels in the microcirculation, may eliminate the increase in extracellular dopamine in the striatum.…”

“…The extracellular level of dopamine in striatum was measured as described in earlier publications (6,(9)(10)(11). The microdialysis samples were collected from the beginning of apnea until 1 min into the recovery period.…”

Impaired Early Neurologic Outcome in Newborn Piglets Reoxygenated with 100% Oxygen Compared with Room Air after Pneumothorax-Induced Asphyxia

“…Similarly, as in another study published recently (41), no additional attempt was made to correct the systemic hypotension or the metabolic acidosis in postasphyxic piglets. In spite of the random allocation, mean arterial blood pressure measured at the start of mechanical ventilation in piglets reoxygenated with 100% O 2 was slightly lower than that in animals treated with room air; however, all of them had values higher than 35 mm Hg, which is the critical level for wellmaintained cerebral perfusion in newborn piglets (42,43). It is worth mentioning that there was no correlation between mean arterial blood pressure and neurologic score in any of the groups.…”

Comparison of the efficacy of blood and polyethylene glycol‐hemoglobin in recovery of newborn piglets from hemorrhagic hypotension: effect on blood pressure, cortical oxygen, and extracellular dopamine in the brain

“…These data are in agreement with our previously published results on the effect of hemorrhagic hypotension on cortical oxygen pressure and extracellular dopamine in brain of newborn piglets. 21 When PEG-Hb solution was infused in place of whole blood, the MABP and cortical oxygen pressure also returned to control values within the first few minutes.…”